PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways (Q45259661)

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scientific article published in April 2005

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English	PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways	scientific article published in April 2005

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways (English)

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Europe PubMed Central

PubMed publication ID

11 December 2017

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D C Linch

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11 December 2017

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R E Gale

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11 December 2017

author name string

V L Grandage

1

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11 December 2017

A Khwaja

4

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11 December 2017

publication date

1 April 2005

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11 December 2017

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11 December 2017

19

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11 December 2017

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11 December 2017

586-594

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11 December 2017

Class I phosphoinositide 3-kinases.

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403653

7 January 2021

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403653

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Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403653

7 January 2021

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Survival of acute myeloid leukemia cells requires PI3 kinase activation

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Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias

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Variable product purity and functional capacity after CD34 selection: a direct comparison of the CliniMACS (v2.1) and Isolex 300i (v2.5) clinical scale devices

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The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the Unite

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Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibit

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Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

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Construction and characterization of a conditionally active version of the serine/threonine kinase Akt.

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Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia

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Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

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Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes.

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Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338

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Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes

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Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells

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The role of p53 in chemosensitivity and radiosensitivity.

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Prognostic value of p53 gene mutations and the product expression in de novo acute myeloid leukemia

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FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia.

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Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals.

1 reference

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Role of PI3-kinase in Bcl-X induction and apoptosis inhibition mediated by IL-3 or IGF-1 in Baf-3 cells

1 reference

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Identifiers

10.1038/SJ.LEU.2403653

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

Dimensions Publication ID

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

ResearchGate publication ID

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