2-Methoxyestradiol confers neuroprotection and inhibits a maladaptive HIF-1α response after traumatic brain injury in mice. (Q45177122)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606183%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

title

2-Methoxyestradiol confers neuroprotection and inhibits a maladaptive HIF-1α response after traumatic brain injury in mice (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606183%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606183%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606183%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606183%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

Eva-Verena Schaible

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606183%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

Julia Windschügl

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606183%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

Wiesia Bobkiewicz

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606183%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

Yordan Kaburov

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606183%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

Larissa Dangel

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606183%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

Anne Sebastiani

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606183%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

Clara Luh

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606183%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

Christian Werner

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606183%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

Kristin Engelhard

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606183%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

Michael K E Schäfer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606183%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

language of work or name

English

0 references

publication date

2 April 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606183%20AND%20SRC:MED&resulttype=core&format=json

Journal of Neurochemistry

9 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606183%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

volume

129

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606183%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606183%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

page(s)

940-954

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606183%20AND%20SRC:MED&resulttype=core&format=json

Expression of the gene encoding the pro-apoptotic BNIP3 protein and stimulation of hypoxia-inducible factor-1alpha (HIF-1alpha) protein following focal cerebral ischemia in rats.

9 March 2020

cites work

1 reference

Prosurvival and prodeath effects of hypoxia-inducible factor-1alpha stabilization in a murine hippocampal cell line.

21 January 2018

1 reference

Antioxidants, HIF prolyl hydroxylase inhibitors or short interfering RNAs to BNIP3 or PUMA, can prevent prodeath effects of the transcriptional activator, HIF-1alpha, in a mouse hippocampal neuronal line

21 January 2018

1 reference

Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription

21 January 2018

1 reference

Sumoylation increases HIF-1alpha stability and its transcriptional activity

21 January 2018

1 reference

Mouse models for preeclampsia: disruption of redox-regulated signaling

21 January 2018

1 reference

Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia

21 January 2018

1 reference

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

21 January 2018

1 reference

Gender and estrogen manipulation do not affect traumatic brain injury in mice

21 January 2018

1 reference

Microtubule disruption targets HIF-1α mRNA to cytoplasmic P-bodies for translational repression

21 January 2018

1 reference

Microtubules regulate hypoxia-inducible factor-1α protein trafficking and activity: implications for taxane therapy

21 January 2018

1 reference

Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons

21 January 2018

1 reference

Superoxide-dependent and -independent mitochondrial signaling during apoptosis in multiple myeloma cells

21 January 2018

1 reference

Multiple effects of 2ME2 and D609 on the cortical expression of HIF-1alpha and apoptotic genes in a middle cerebral artery occlusion-induced focal ischemia rat model

21 January 2018

1 reference

Prodeath or prosurvival: two facets of hypoxia inducible factor-1 in perinatal brain injury

21 January 2018

1 reference

Hypoxia inducible factor 1-alpha (HIF-1 alpha) is induced during reperfusion after renal ischemia and is critical for proximal tubule cell survival.

21 January 2018

1 reference

2-Methoxyestradiol inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation

21 January 2018

1 reference

Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model

21 January 2018

1 reference

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

21 January 2018

1 reference

The role and regulation of hypoxia-inducible factor-1alpha expression in brain development and neonatal hypoxic-ischemic brain injury

21 January 2018

1 reference

Antiangiogenic effect of oral 2-methoxyestradiol on choroidal neovascularization in mice

21 January 2018

1 reference

The role of hypoxia-inducible factor 1 in atherosclerosis

21 January 2018

1 reference

Elevation of tumor necrosis factor in head injury

21 January 2018

1 reference

Identification of alternative spliced variants of human hypoxia-inducible factor-1alpha

21 January 2018

1 reference

The updated biology of hypoxia-inducible factor

21 January 2018

1 reference

Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1).

21 January 2018

1 reference

Cytokines and innate inflammation in the pathogenesis of human traumatic brain injury.

21 January 2018

1 reference

Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage.

21 January 2018

1 reference

Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation

21 January 2018

1 reference

Temporal changes in cell marker expression and cellular infiltration in a controlled cortical impact model in adult male C57BL/6 mice

21 January 2018

1 reference

Hypoxia-inducible factor prolyl hydroxylase inhibition: robust new target or another big bust for stroke therapeutics?

21 January 2018

1 reference

Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes

21 January 2018

1 reference

Early neuronal expression of tumor necrosis factor-alpha after experimental brain injury contributes to neurological impairment

21 January 2018

1 reference

Metallocorroles as cytoprotective agents against oxidative and nitrative stress in cellular models of neurodegeneration

21 January 2018

1 reference

CREB activation mediates VEGF-A's protection of neurons and cerebral vascular endothelial cells.

21 January 2018

1 reference

HIF-1α involves in neuronal apoptosis after traumatic brain injury in adult rats

21 January 2018

1 reference

Molecular regulation of the PAI-1 gene by hypoxia: contributions of Egr-1, HIF-1alpha, and C/EBPalpha.

21 January 2018

1 reference

Sequential alterations in haemorheology, endothelial dysfunction, platelet activation and thrombogenesis in relation to prognosis following acute stroke: The West Birmingham Stroke Project

21 January 2018

1 reference

Turn me on: regulating HIF transcriptional activity.

21 January 2018

1 reference

Inhibition of myosin light chain kinase reduces brain edema formation after traumatic brain injury.

21 January 2018

1 reference

Influence of a brief episode of anesthesia during the induction of experimental brain trauma on secondary brain damage and inflammation

21 January 2018

1 reference

2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.

21 January 2018

1 reference

Pathomechanistic characterization of two exonic L1CAM variants located in trans in an obligate carrier of X-linked hydrocephalus.

21 January 2018

1 reference

Mechanism of action of 2-methoxyestradiol: new developments

21 January 2018

1 reference

2-Methoxyestradiol--biology and mechanism of action

21 January 2018

1 reference

Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1α.

21 January 2018

1 reference

Transcriptional regulation of the Vascular Endothelial Growth Factor gene--a concert of activating factors

21 January 2018

1 reference

p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

21 January 2018

1 reference

2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma

21 January 2018

1 reference

The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans

21 January 2018

1 reference

Single administration of tripeptide α-MSH(11-13) attenuates brain damage by reduced inflammation and apoptosis after experimental traumatic brain injury in mice

21 January 2018

1 reference

Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy

21 January 2018

1 reference

Hydroxylation of HIF-1: oxygen sensing at the molecular level

21 January 2018

1 reference

Hypoxia-inducible factors in physiology and medicine

21 January 2018

1 reference

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

21 January 2018

1 reference

Hypoxia-inducible factors: crosstalk between inflammation and metabolism

21 January 2018

1 reference

Dose-response effects of 2-methoxyestradiol on estrogen target tissues in the ovariectomized rat.

21 January 2018

1 reference

Hypoxia inducible factor-1: its potential role in cerebral ischemia

21 January 2018

1 reference

A Model of Parasagittal Controlled Cortical Impact in the Mouse: Cognitive and Histopathologic Effects

21 January 2018

1 reference

HIF-1 alpha protein as a target for S-nitrosation

21 January 2018

1 reference

2-Methoxyestradiol--a unique blend of activities generating a new class of anti-tumour/anti-inflammatory agents

21 January 2018

1 reference

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

21 January 2018

1 reference

Succinate is an inflammatory signal that induces IL-1β through HIF-1α.

21 January 2018

1 reference

Selection of endogenous control genes for normalization of gene expression analysis after experimental brain trauma in mice

21 January 2018

1 reference

Influence of age on brain edema formation, secondary brain damage and inflammatory response after brain trauma in mice

21 January 2018

1 reference

Estradiol metabolites attenuate monocrotaline-induced pulmonary hypertension in rats

21 January 2018

1 reference

Immuno-inflammatory and thrombotic/fibrinolytic variables associated with acute ischemic stroke diagnosis.

21 January 2018

1 reference

Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity

21 January 2018

1 reference

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

21 January 2018

1 reference

Inhibiting HIF-1α by 2ME2 ameliorates early brain injury after experimental subarachnoid hemorrhage in rats

21 January 2018

1 reference

2-methoxyestradiol reduces cerebral vasospasm after 48 hours of experimental subarachnoid hemorrhage in rats

21 January 2018

1 reference

Digoxin inhibits retinal ischemia-induced HIF-1alpha expression and ocular neovascularization

21 January 2018

1 reference

Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1beta (IL-1beta) in astrocyte cultures

21 January 2018

1 reference

Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/JNC.12708

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606183%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606183%20AND%20SRC:MED&resulttype=core&format=json