Binding sites of gamma-secretase inhibitors in rodent brain: distribution, postnatal development, and effect of deafferentation. (Q44814697)

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scientific article published in March 2004

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English	Binding sites of gamma-secretase inhibitors in rodent brain: distribution, postnatal development, and effect of deafferentation.	scientific article published in March 2004

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PubMed publication ID

15044533

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6 December 2017

title

Binding sites of gamma-secretase inhibitors in rodent brain: distribution, postnatal development, and effect of deafferentation (English)

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6729845

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Xiao-Xin Yan

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1

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6729845

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Tong Li

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2

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6729845

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Cynthia M Rominger

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3

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6729845

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12 May 2020

Shimoga R Prakash

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4

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6729845

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Philip C Wong

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5

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6729845

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Richard E Olson

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6

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6729845

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Robert Zaczek

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7

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PMC publication ID

6729845

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Yu-Wen Li

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8

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6729845

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language of work or name

English

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publication date

1 March 2004

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PubMed publication ID

15044533

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6 December 2017

published in

Journal of Neuroscience

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PMC publication ID

6729845

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12 May 2020

volume

24

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Europe PubMed Central

PMC publication ID

6729845

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12 May 2020

issue

12

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Europe PubMed Central

PMC publication ID

6729845

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12 May 2020

page(s)

2942-2952

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6729845

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12 May 2020

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

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Presenilin is required for proper morphology and function of neurons in C. elegans

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Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organization

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Olfactory centres in Alzheimer's disease: olfactory bulb is involved in early Braak's stages.

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APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

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Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

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Ultrastructural analysis of climbing fiber-Purkinje cell synaptogenesis in the rat cerebellum.

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Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

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Presenilin-dependent gamma-secretase activity modulates neurite outgrowth

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Postnatal maturation of Na+, K+, 2Cl- cotransporter expression and inhibitory synaptogenesis in the rat hippocampus: an immunocytochemical analysis

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Enriched odor exposure increases the number of newborn neurons in the adult olfactory bulb and improves odor memory.

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12 December 2020

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Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications

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12 December 2020

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Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

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Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals

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The mechanism of gamma-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors

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12 December 2020

based on heuristic

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γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/15044533

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12 December 2020

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An autoradiographic analysis of histogenesis in the mouse cerebellum

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12 December 2020

based on heuristic

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Regulatory roles of presenilin-1 and nicastrin in neuronal differentiation during in vitro neurogenesis

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Maturation of rat visual cortex. III. Postnatal morphogenesis and synaptogenesis of local circuit neurons

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Immunocytochemical localization of the precursor protein for beta-amyloid in the rat central nervous system

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Postnatal development of axosomatic synapses in the rat visual cortex: morphogenesis and quantitative evaluation

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12 December 2020

based on heuristic

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Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb

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based on heuristic

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Neurons in the rat dentate gyrus granular layer substantially increase during juvenile and adult life

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12 December 2020

based on heuristic

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Development of the hippocampal region in the rat. II. Morphogenesis during embryonic and early postnatal life.

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https://pubmed.ncbi.nlm.nih.gov/15044533

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurogenesis and cell death in olfactory epithelium

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/15044533

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/15044533

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Building action repertoires: memory and learning functions of the basal ganglia

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/15044533

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/15044533

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/15044533

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical analysis of presenilin-1 expression in the mouse brain

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/15044533

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/15044533

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of presenilin-1 and -2 mRNAs in rat and Alzheimer's disease brains

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/15044533

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/15044533

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/15044533

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoreactivity of presenilin-1 in human, rat and mouse brain

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/15044533

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical analysis of presenilin 2 expression in the mouse brain: distribution pattern and co-localization with presenilin 1 protein

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/15044533

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of amyloid in the pathogenesis of Alzheimer's disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/15044533

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/15044533

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evolution of neuronal changes in the course of Alzheimer's disease.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/15044533

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-1 mRNA and beta-amyloid precursor protein mRNA are expressed in the developing rat olfactory and vestibulocochlear systems

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/15044533

retrieved

12 December 2020

based on heuristic

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Identifiers

DOI

10.1523/JNEUROSCI.0092-04.2004

1 reference

stated in

Europe PubMed Central

PMC publication ID

6729845

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729845&resulttype=core&format=json

retrieved

12 May 2020

PMC publication ID

6729845

1 reference

stated in

Europe PubMed Central

PMC publication ID

6729845

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729845&resulttype=core&format=json

retrieved

12 May 2020

PubMed publication ID

15044533

1 reference

stated in

Europe PubMed Central

PMC publication ID

6729845

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729845&resulttype=core&format=json

retrieved

12 May 2020

ResearchGate publication ID

8655425

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