Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition (Q44588830)

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scientific article published in September 2003

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English	Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition	scientific article published in September 2003

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scholarly article

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Europe PubMed Central

PubMed publication ID

4 December 2017

Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition (English)

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Europe PubMed Central

PubMed publication ID

4 December 2017

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Paul Dent

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4 December 2017

author name string

Mohamed Rahmani

1

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4 December 2017

Chunrong Yu

2

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4 December 2017

Erin Reese

3

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4 December 2017

Wesam Ahmed

4

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4 December 2017

Karen Hirsch

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4 December 2017

Steven Grant

7

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4 December 2017

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publication date

1 September 2003

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4 December 2017

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4 December 2017

22

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4 December 2017

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4 December 2017

6231-6242

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4 December 2017

Mechanism of activation and function of protein kinase B.

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Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

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HL-60 cells induced to differentiate towards neutrophils subsequently die via apoptosis

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Elevated AKT activity protects the prostate cancer cell line LNCaP from TRAIL-induced apoptosis

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Phosphatidylinositol 3-kinase regulates PMA-induced differentiation and superoxide production in HL-60 cells

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The histone deacetylase inhibitor sodium butyrate interacts synergistically with phorbol myristate acetate (PMA) to induce mitochondrial damage and apoptosis in human myeloid leukemia cells through a tumor necrosis factor-alpha-mediated process

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AKT plays a central role in tumorigenesis

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Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site

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Glucagon-like peptide-2 receptor activation engages bad and glycogen synthase kinase-3 in a protein kinase A-dependent manner and prevents apoptosis following inhibition of phosphatidylinositol 3-kinase.

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Histone acetylation in chromatin structure and transcription

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Phosphatidylinositol 3-Kinase Is Required for Integrin-Stimulated AKT and Raf-1/Mitogen-Activated Protein Kinase Pathway Activation

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10.1038/SJ.ONC.1206646

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Europe PubMed Central

PubMed publication ID

4 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

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