Synergistic regulation of serotonin and opioid signaling contributes to pain insensitivity in Nav1.7 knockout mice. (Q44342560)

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5 April 2020

title

Synergistic regulation of serotonin and opioid signaling contributes to pain insensitivity in Nav1.7 knockout mice (English)

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Leonhardt Krahé

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Katharina Moeller

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Jane E Sexton

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Xiaohui Sun

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John N Wood

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publication date

10 January 2017

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volume

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issue

461

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cAMP-dependent phosphorylation of the tetrodotoxin-resistant voltage-dependent sodium channel SNS.

5 April 2020

cites work

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12 December 2020

Selective stimulation of colonic transit by the benzofuran 5HT4 agonist, prucalopride, in healthy humans

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12 December 2020

The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways

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Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance

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Localization of the 5-HT(4) receptor in the human and the guinea pig colon

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Analgesic synergy between topical lidocaine and topical opioids

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12 December 2020

5HT increases excitability of nociceptor-like rat dorsal root ganglion neurons via cAMP-coupled TTX-resistant Na(+) channels

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12 December 2020

Descending control of pain

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12 December 2020

Heterologous sensitization of adenylate cyclase is protein kinase A-dependent in Cath.a differentiated (CAD)-D2L cells

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12 December 2020

5-HT4(a) receptors avert opioid-induced breathing depression without loss of analgesia

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12 December 2020

Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain

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12 December 2020

SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype

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12 December 2020

Interaction of the central analgesic, tramadol, with the uptake and release of 5-hydroxytryptamine in the rat brain in vitro

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12 December 2020

An SCN9A channelopathy causes congenital inability to experience pain

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12 December 2020

Continuous delta-opioid receptor activation reduces neuronal voltage-gated sodium channel (NaV1.7) levels through activation of protein kinase C in painful diabetic neuropathy

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12 December 2020

ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors.

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12 December 2020

Compensation in flow cytometry

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12 December 2020

A difficult balance--pain management, drug safety, and the FDA.

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12 December 2020

Treatment of chronic non-cancer pain

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12 December 2020

PKA regulatory subunits mediate synergy among conserved G-protein-coupled receptor cascades.

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12 December 2020

Reduction of voltage gated sodium channel protein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathy

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12 December 2020

Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons

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12 December 2020

The economic costs of pain in the United States

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12 December 2020

Opioid epidemic in the United States.

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12 December 2020

Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.

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Opioids compared to placebo or other treatments for chronic low-back pain

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12 December 2020

Opioids for neuropathic pain

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12 December 2020

Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons

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Molecular control of δ-opioid receptor signalling

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12 December 2020

Regulating excitability of peripheral afferents: emerging ion channel targets

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12 December 2020

The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors

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12 December 2020

Analgesic efficacy of opioids in chronic pain: recent meta-analyses

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12 December 2020

Allosteric sodium in class A GPCR signaling

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12 December 2020

Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain

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12 December 2020

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

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12 December 2020

Disruption of the Na+ ion binding site as a mechanism for positive allosteric modulation of the mu-opioid receptor

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12 December 2020

Subgroup-elimination transcriptomics identifies signaling proteins that define subclasses of TRPV1-positive neurons and a novel paracrine circuit

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12 December 2020

Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme

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12 December 2020

Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7

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12 December 2020

Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief

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12 December 2020

Allostatic Mechanisms of Opioid Tolerance Beyond Desensitization and Downregulation

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12 December 2020

A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system

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12 December 2020

Opiate agonists and antagonists discriminated by receptor binding in brain

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12 December 2020

Antagonists of 5-HT4 receptor-mediated responses in adult hippocampal neurons

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12 December 2020

PGE2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase A cascade

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12 December 2020

5HT4Receptors Couple Positively to Tetrodotoxin-Insensitive Sodium Channels in a Subpopulation of Capsaicin-Sensitive Rat Sensory Neurons

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12 December 2020

10.1126/SCISIGNAL.AAH4874

Identifiers

DOI

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5 April 2020

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5 April 2020

PubMed publication ID

28074005

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