Binding site of macrolide antibiotics on the ribosome: new resistance mutation identifies a specific interaction of ketolides with rRNA (Q33997135)

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3 December 2019

title

Binding site of macrolide antibiotics on the ribosome: new resistance mutation identifies a specific interaction of ketolides with rRNA (English)

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3 December 2019

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3 December 2019

L Xiong

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3 December 2019

P Zhong

series ordinal

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3 December 2019

A Mankin

series ordinal

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3 December 2019

language of work or name

English

0 references

publication date

1 December 2001

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3 December 2019

published in

Journal of Bacteriology

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3 December 2019

volume

183

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3 December 2019

issue

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3 December 2019

page(s)

6898-6907

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The polypeptide tunnel system in the ribosome and its gating in erythromycin resistance mutants of L4 and L22.

3 December 2019

cites work

1 reference

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Comparative in vitro activity of ABT-773, a novel antibacterial ketolide

5 July 2018

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A novel site of antibiotic action in the ribosome: interaction of evernimicin with the large ribosomal subunit.

5 July 2018

1 reference

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Macrolide resistance conferred by base substitutions in 23S rRNA.

5 July 2018

1 reference

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Inhibition of the ribosomal peptidyl transferase reaction by the mycarose moiety of the antibiotics carbomycin, spiramycin and tylosin

5 July 2018

1 reference

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Oxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action.

5 July 2018

1 reference

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The structural basis of ribosome activity in peptide bond synthesis

5 July 2018

1 reference

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The complete atomic structure of the large ribosomal subunit at 2.4 A resolution

5 July 2018

1 reference

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Mutations in 23S rRNA and ribosomal protein L4 account for resistance in pneumococcal strains selected in vitro by macrolide passage

5 July 2018

1 reference

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Construction and initial characterization of Escherichia coli strains with few or no intact chromosomal rRNA operons.

5 July 2018

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An Escherichia coli strain with all chromosomal rRNA operons inactivated: complete exchange of rRNA genes between bacteria

5 July 2018

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A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=95531

The macrolide-ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=95531

In vitro activities of the new ketolide antibiotics HMR 3004 and HMR 3647 against Streptococcus pneumoniae in Germany.

5 July 2018

1 reference

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Ribosomal protein gene sequence changes in erythromycin-resistant mutants of Escherichia coli

5 July 2018

1 reference

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Erythromycin resistance by ribosome modification

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=95531

Identification of two erythromycin resistance mutations in the mitochondrial gene coding for the large ribosomal RNA in yeast

5 July 2018

1 reference

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Erythromycin resistance due to a mutation in a ribosomal RNA operon of Escherichia coli

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=95531

Erythromycin, carbomycin, and spiramycin inhibit protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=95531

Altered methylation of ribosomal RNA in an erythromycin-resistant strain of Staphylococcus aureus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=95531

Genetic studies of erythromycin resistant mutants of Escherichia coli

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=95531

Biochemical and genetic studies on two different types of erythromycin resistant mutants of Escherichia coli with altered ribosomal proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=95531

Comparative anatomy of 16-S-like ribosomal RNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=95531

Chloramphenicol, erythromycin, carbomycin and vernamycin B protect overlapping sites in the peptidyl transferase region of 23S ribosomal RNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=95531

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors

5 July 2018

1 reference

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Isolation of temperature-sensitive mutants of 16 S rRNA in Escherichia coli.

5 July 2018

1 reference

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Structural analysis of RNA using chemical and enzymatic probing monitored by primer extension

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=95531

Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=95531

Erythromycin resistance mutations in ribosomal proteins L22 and L4 perturb the higher order structure of 23 S ribosomal RNA.

5 July 2018

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Gene organization and primary structure of a ribosomal RNA operon from Escherichia coli

29 October 2018

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Protein components of the erythromycin binding site in bacterial ribosomes

29 October 2018

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12 December 2020

Erythromycin inhibits the assembly of the large ribosomal subunit in growing Escherichia coli cells

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12 December 2020

The antibiotic thiostrepton inhibits a functional transition within protein L11 at the ribosomal GTPase centre 1 1Edited by D. E. Draper

1 reference

12 December 2020

Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA

1 reference

12 December 2020

Site of action of a ribosomal RNA methylase responsible for resistance to erythromycin and other antibiotics

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12 December 2020

10.1128/JB.183.23.6898-6907.2001

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11698379%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

1 reference

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3 December 2019

PubMed publication ID

11698379

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11698379%20AND%20SRC:MED&resulttype=core&format=json