Childhood brain tumors: epidemiology, current management and future directions (Q33970971)

30 July 2017

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title

Childhood brain tumors: epidemiology, current management and future directions (English)

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30 July 2017

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Ian F Pollack

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30 July 2017

Regina I Jakacki

series ordinal

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30 July 2017

language of work or name

English

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publication date

26 July 2011

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30 July 2017

published in

Nature Reviews Neurology

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30 July 2017

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30 July 2017

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30 July 2017

page(s)

495-506

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Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma.

30 July 2017

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Preliminary results from a Phase II trail of conformal radiation therapy for pediatric patients with localised low-grade astrocytoma and ependymoma

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Three- and four-year cognitive outcome in children with noncortical brain tumors treated with whole-brain radiotherapy

21 January 2018

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Factors affecting intellectual outcome in pediatric brain tumor patients

21 January 2018

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Proton versus photon radiotherapy for common pediatric brain tumors: comparison of models of dose characteristics and their relationship to cognitive function

21 January 2018

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The treatment of medulloblastoma. Results of a prospective randomized trial of radiation therapy with and without CCNU, vincristine, and prednisone

21 January 2018

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The effectiveness of chemotherapy for treatment of high grade astrocytoma in children: results of a randomized trial. A report from the Childrens Cancer Study Group

21 January 2018

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Weekly vinblastine in pediatric low-grade glioma patients with carboplatin allergic reaction.

21 January 2018

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Carboplatin and vincristine chemotherapy for children with newly diagnosed progressive low-grade gliomas.

21 January 2018

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Results of a policy of surveillance alone after surgical management of pediatric low grade gliomas

21 January 2018

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Benign astrocytic and oligodendrocytic tumors of the cerebral hemispheres in children

21 January 2018

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Low-grade gliomas of the cerebral hemispheres in children: an analysis of 71 cases.

21 January 2018

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Current and future strategies in radiotherapy of childhood low-grade glioma of the brain. Part I: Treatment modalities of radiation therapy

21 January 2018

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Phase II TPDCV protocol for pediatric low-grade hypothalamic/chiasmatic gliomas: 15-year update

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

A lower-dose, lower-toxicity cisplatin-etoposide regimen for childhood progressive low-grade glioma

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas

21 January 2018

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BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

BRAF activation induces transformation and then senescence in human neural stem cells: a pilocytic astrocytoma model.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Initial testing (stage 1) of AZD6244 (ARRY-142886) by the Pediatric Preclinical Testing Program.

21 January 2018

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Phase I Trial of Lenalidomide in Pediatric Patients With Recurrent, Refractory, or Progressive Primary CNS Tumors: Pediatric Brain Tumor Consortium Study PBTC-018

21 January 2018

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Rapamycin (sirolimus) in tuberous sclerosis associated pediatric central nervous system tumors

21 January 2018

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Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis

21 January 2018

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Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors

21 January 2018

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Prediction of central nervous system embryonal tumour outcome based on gene expression

21 January 2018

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Subtypes of medulloblastoma have distinct developmental origins

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Medulloblastoma comprises four distinct molecular variants

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

The genetic landscape of the childhood cancer medulloblastoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

The 2007 WHO classification of tumours of the central nervous system

21 January 2018

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Analysis of patients with supratentorial primitive neuro-ectodermal tumours entered into the SIOP/UKCCSG PNET 3 study

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Outcome for patients with metastatic (M2-3) medulloblastoma treated with SIOP/UKCCSG PNET-3 chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Universal poor survival in children with medulloblastoma harboring somatic TP53 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Large cell/anaplastic medulloblastoma: outcome according to myc status, histopathological, and clinical risk factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Radiotherapy in pediatric medulloblastoma: quality assessment of Pediatric Oncology Group Trial 9031.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Medulloblastoma growth inhibition by hedgehog pathway blockade

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

A multi-institutional retrospective study of intracranial ependymoma in children: identification of risk factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Survival and prognostic factors following radiation therapy and chemotherapy for ependymomas in children: a report of the Children's Cancer Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Influence of tumor grade on time to progression after irradiation for localized ependymoma in children

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Treatment of intracranial ependymoma by surgery alone

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors

21 January 2018

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Carboplatin in childhood brain tumors. A Children's Cancer Study Group Phase II trial

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Multifactorial analysis of predictors of outcome in pediatric intracranial ependymoma

21 January 2018

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Human telomere reverse transcriptase expression predicts progression and survival in pediatric intracranial ependymoma

21 January 2018

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Radial glia cells are candidate stem cells of ependymoma

21 January 2018

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Cross-species genomics matches driver mutations and cell compartments to model ependymoma

21 January 2018

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Phase II study of high-dose chemotherapy before radiation in children with newly diagnosed high-grade astrocytoma: final analysis of Children's Cancer Group Study 9933.

21 January 2018

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Prognostic factors in pediatric high-grade astrocytoma: the importance of accurate pathologic diagnosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

The influence of central review on outcome associations in childhood malignant gliomas: results from the CCG-945 experience

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Expression of p53 and prognosis in children with malignant gliomas.

21 January 2018

1 reference

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O6-methylguanine-DNA methyltransferase expression strongly correlates with outcome in childhood malignant gliomas: results from the CCG-945 Cohort

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

MGMT gene silencing and benefit from temozolomide in glioblastoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

A phase I trial of temozolomide and lomustine in newly diagnosed high-grade gliomas of childhood

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

An integrated genomic analysis of human glioblastoma multiforme

21 January 2018

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IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children's Oncology Group

21 January 2018

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Phase I study of SU5416, a small molecule inhibitor of the vascular endothelial growth factor receptor (VEGFR) in refractory pediatric central nervous system tumors

21 January 2018

1 reference

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Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Expression of glioma-associated antigens in pediatric brain stem and non-brain stem gliomas.

21 January 2018

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Dendritic cell therapy of high-grade gliomas.

21 January 2018

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Magnetic resonance scans should replace biopsies for the diagnosis of diffuse brain stem gliomas: a report from the Children's Cancer Group.

21 January 2018

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Intrinsic brain-stem tumors of childhood: surgical indications

21 January 2018

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The long-term outcome after surgical treatment of dorsally exophytic brain-stem gliomas

21 January 2018

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Outcome of children with brain stem gliomas after treatment with 7800 cGy of hyperfractionated radiotherapy. A Childrens Cancer Group Phase I/II Trial.

21 January 2018

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High dose chemotherapy with autologous bone marrow rescue for children with diffuse pontine brain stem tumors. Children's Cancer Group

21 January 2018

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Pre-irradiation chemotherapy and hyperfractionated radiation therapy 66 Gy for children with brain stem tumors. A phase II study of the Pediatric Oncology Group, Protocol 8833.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Topotecan as a radiosensitizer in the treatment of children with malignant diffuse brainstem gliomas: results of a French Society of Paediatric Oncology Phase II Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Motexafin gadolinium and involved field radiation therapy for intrinsic pontine glioma of childhood: a Children's Oncology Group phase I study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Phase II trial of tipifarnib and radiation in children with newly diagnosed diffuse intrinsic pontine gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Phase I trial of imatinib in children with newly diagnosed brainstem and recurrent malignant gliomas: a Pediatric Brain Tumor Consortium report

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

A phase II study of gefitinib and irradiation in children with newly diagnosed brainstem gliomas: a report from the Pediatric Brain Tumor Consortium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Treatment of traumatic brain injury in rats with erythropoietin and carbamylated erythropoietin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Prospective study of awake craniotomy used routinely and nonselectively for supratentorial tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Real-time image-guided direct convective perfusion of intrinsic brainstem lesions. Technical note

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Multiagent chemotherapy and deferred radiotherapy in infants with malignant brain tumors: a report from the Children's Cancer Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Outcome of children less than three years old at diagnosis with non-metastatic medulloblastoma treated with chemotherapy on the "Head Start" I and II protocols.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Treatment of medulloblastoma with postoperative chemotherapy alone: an SFOP prospective trial in young children.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Treatment of early childhood medulloblastoma by postoperative chemotherapy alone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Spectrum of SMARCB1/INI1 mutations in familial and sporadic rhabdoid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Intensive Multimodality Treatment for Children With Newly Diagnosed CNS Atypical Teratoid Rhabdoid Tumor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Atypical teratoid or rhabdoid tumors: improved outcome with high-dose chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Atypical teratoid/rhabdoid tumors (ATRT): improved survival in children 3 years of age and older with radiation therapy and high-dose alkylator-based chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Medulloblastoma variants: age-dependent occurrence and relation to Gorlin syndrome--a new clinical perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Neurologic sequelae of brain tumors in children

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Postoperative cerebellar mutism syndrome following treatment of medulloblastoma: neuroradiographic features and origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

21 January 2018

Brain tumors in children

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Childhood central nervous system tumours--incidence and survival in Europe (1978-1997): report from Automated Childhood Cancer Information System project.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Tumors of the brain and nervous system after radiotherapy in childhood

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Delay in diagnosis of children with cancer: a retrospective study of 315 children

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Randomized phase III trial in childhood high-grade astrocytoma comparing vincristine, lomustine, and prednisone with the eight-drugs-in-1-day regimen. Childrens Cancer Group.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Proton radiotherapy for childhood ependymoma: initial clinical outcomes and dose comparisons

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Low-stage medulloblastoma: final analysis of trial comparing standard-dose with reduced-dose neuraxis irradiation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Treatment of children with medulloblastomas with reduced-dose craniospinal radiation therapy and adjuvant chemotherapy: A Children's Cancer Group Study.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Brain-stem tumors in childhood: a prospective randomized trial of irradiation with and without adjuvant CCNU, VCR, and prednisone. A report of the Childrens Cancer Study Group

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

INI1 protein expression distinguishes atypical teratoid/rhabdoid tumor from choroid plexus carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

31 March 2020

Posterior Fossa Syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.110

Rarity of PTEN deletions and EGFR amplification in malignant gliomas of childhood: results from the Children's Cancer Group 945 cohort

31 March 2020

1 reference

12 December 2020

Adjuvant chemotherapy for medulloblastoma: the first multi-centre control trial of the International Society of Paediatric Oncology (SIOP I).

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12 December 2020

Neurocognitive outcome 12 months following cerebellar mutism syndrome in pediatric patients with medulloblastoma.

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12 December 2020

Final results of a study of escalating doses of hyperfractionated radiotherapy in brain stem tumors in children: a Pediatric Oncology Group study

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12 December 2020

Sporadic medulloblastomas contain PTCH mutations.

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12 December 2020

Increased incidence rates but no space-time clustering of childhood astrocytoma in Sweden, 1973-1992: a population-based study of pediatric brain tumors

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12 December 2020

Results of positron emission tomography guidance and reassessment of the utility of and indications for stereotactic biopsy in children with infiltrative brainstem tumors

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12 December 2020

Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors

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12 December 2020

Adjuvant chemotherapy for the treatment of intracranial ependymoma of childhood

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12 December 2020

Stereotactic biopsy of diffuse pontine lesions in children

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12 December 2020

10.1038/NRNEUROL.2011.110

Identifiers

DOI

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Dimensions Publication ID

30 July 2017

1048104063

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