CCN2 is required for the TGF-β induced activation of Smad1-Erk1/2 signaling network (Q33961583)

30 July 2017

title

CCN2 is required for the TGF-β induced activation of Smad1-Erk1/2 signaling network (English)

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30 July 2017

Andreea M Bujor

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Maria Trojanowska

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Sashidhar S Nakerakanti

series ordinal

1 reference

30 July 2017

language of work or name

English

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publication date

8 July 2011

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30 July 2017

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30 July 2017

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30 July 2017

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30 July 2017

page(s)

e21911

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Creative Commons Attribution 4.0 International

30 July 2017

start time

8 July 2011

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April 2022 Public Data File from Crossref

copyrighted

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cites work

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CCN2 is required for bleomycin‐induced skin fibrosis in mice

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Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis

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Phosphorylation of Fli1 at threonine 312 by protein kinase C delta promotes its interaction with p300/CREB-binding protein-associated factor and subsequent acetylation in response to transforming growth factor beta

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TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch

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uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180.

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A polymorphism in the CTGF promoter region associated with systemic sclerosis.

5 July 2018

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Integrin-regulated FAK-Src signaling in normal and cancer cells

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Angiotensin II-dependent Src and Smad1 signaling pathway is crucial for the development of diabetic nephropathy

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Connective tissue growth factor CCN2 interacts with and activates the tyrosine kinase receptor TrkA

5 July 2018

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alpha(v)beta(3) Integrin interacts with the transforming growth factor beta (TGFbeta) type II receptor to potentiate the proliferative effects of TGFbeta1 in living human lung fibroblasts

5 July 2018

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Role of connective tissue growth factor in renal tubular epithelial-myofibroblast transdifferentiation and extracellular matrix accumulation in vitro

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta

5 July 2018

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The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts

5 July 2018

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5 July 2018

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5 July 2018

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Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model

5 July 2018

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Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo

5 July 2018

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TGF-beta signal transduction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132735

Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132735

Connective tissue growth factor: a mediator of TGF-β action on fibroblasts

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132735

Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways.

5 July 2018

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Transforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021911

The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021911

Signaling events required for transforming growth factor-beta stimulation of connective tissue growth factor expression by cultured human lung fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021911

Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021911

Src kinases in systemic sclerosis: central roles in fibroblast activation and in skin fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021911

Akt inhibition up-regulates MMP1 through a CCN2-dependent pathway in human dermal fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021911

Smad1 pathway is activated in systemic sclerosis fibroblasts and is targeted by imatinib mesylate

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021911

Fli1 and Ets1 have distinct roles in connective tissue growth factor/CCN2 gene regulation and induction of the profibrotic gene program

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021911

Regulation of connective tissue growth factor expression by prostaglandin E(2)

21 January 2018

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12 December 2020

Role of connective tissue growth factor in profibrotic action of transforming growth factor-beta: a potential target for preventing renal fibrosis

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12 December 2020

Expression and differential regulation of connective tissue growth factor in pancreatic cancer cells

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12 December 2020

Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP

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12 December 2020

Smad3 and extracellular signal-regulated kinase 1/2 coordinately mediate transforming growth factor-beta-induced expression of connective tissue growth factor in human fibroblasts

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0021911

Identifiers

DOI

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30 July 2017

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30 July 2017

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