Genotype-guided tamoxifen therapy: time to pause for reflection? (Q33955759)

30 July 2017

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title

Genotype-guided tamoxifen therapy: time to pause for reflection? (English)

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30 July 2017

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Stephen Hamilton-Dutoit

series ordinal

object named as

Stephen Hamilton-Dutoit

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Henrik Toft Sørensen

series ordinal

object named as

Henrik Toft Sørensen

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Timothy L Lash

series ordinal

object named as

Timothy L Lash

1 reference

30 July 2017

Ernst A Lien

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30 July 2017

publication date

1 August 2009

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Lancet Oncology Commission

30 July 2017

published in

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30 July 2017

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30 July 2017

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30 July 2017

page(s)

825-833

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The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells

30 July 2017

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Pharmacogenomic variation of CYP2D6 and the choice of optimal adjuvant endocrine therapy for postmenopausal breast cancer: a modeling analysis

5 July 2018

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A model citizen? Is tamoxifen more effective than aromatase inhibitors if we pick the right patients?

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes

5 July 2018

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Germline pharmacogenetics of tamoxifen response: have we learned enough?

5 July 2018

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5 July 2018

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New insights into the metabolism of tamoxifen and its role in the treatment and prevention of breast cancer

5 July 2018

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5 July 2018

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CYP2D6 polymorphisms and the impact on tamoxifen therapy

5 July 2018

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5 July 2018

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Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer

5 July 2018

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The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen

5 July 2018

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What clinicians need to know about antioestrogen resistance in breast cancer therapy

5 July 2018

1 reference

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Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells

5 July 2018

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Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients

5 July 2018

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Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients

5 July 2018

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Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials

5 July 2018

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Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen.

5 July 2018

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CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment

5 July 2018

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Mechanisms of tamoxifen resistance

5 July 2018

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American Society of Clinical Oncology technology assessment on the use of aromatase inhibitors as adjuvant therapy for postmenopausal women with hormone receptor-positive breast cancer: status report 2004.

5 July 2018

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Ligand-independent and agonist-mediated degradation of estrogen receptor-alpha in breast carcinoma cells: evidence for distinct degradative pathways

5 July 2018

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First-line endocrine treatment of breast cancer: aromatase inhibitor or antioestrogen?

5 July 2018

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5 July 2018

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5 July 2018

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Hormonal effects of aromatase inhibitors: focus on premenopausal effects and interaction with tamoxifen

5 July 2018

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Pharmacogenetics of antidepressant medication intolerance

5 July 2018

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The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver

5 July 2018

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Fallibility in estimating direct effects

5 July 2018

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Influence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6

5 July 2018

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5 July 2018

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Evidence for the metabolic activation of non-steroidal antioestrogens: a study of structure-activity relationships

5 July 2018

1 reference

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A comparison of two doses of tamoxifen (Nolvadex) in postmenopausal women with advanced breast cancer: 10 mg bd versus 20 mg bd.

5 July 2018

1 reference

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The value of high dose tamoxifen in postmenopausal breast cancer patients progressing on standard doses: A pilot study

5 July 2018

1 reference

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A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895727

Impact of CYP2D6 polymorphisms in tamoxifen adjuvant breast cancer treatment

5 July 2018

1 reference

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Genetic polymorphisms of CYP2D6 10 and CYP2C19 2, 3 are not associated with prognosis, endometrial thickness, or bone mineral density in Japanese breast cancer patients treated with adjuvant tamoxifen

29 October 2018

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Estrogen- and progesterone-receptor status in ECOG 2197: comparison of immunohistochemistry by local and central laboratories and quantitative reverse transcription polymerase chain reaction by central laboratory

29 October 2018

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Association between CYP2D6 *10 genotype and survival of breast cancer patients receiving tamoxifen treatment.

29 October 2018

1 reference

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Modification of tamoxifen response: what have we learned?

29 October 2018

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Impact of CYP2D6*10 on recurrence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy

29 October 2018

1 reference

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Pharmacogenomics of tamoxifen and aromatase inhibitors

29 October 2018

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Predictors of tamoxifen discontinuation among older women with estrogen receptor-positive breast cancer

29 October 2018

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Tamoxifen or raloxifene for breast cancer chemoprevention: a tale of two choices--point

29 October 2018

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Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism

29 October 2018

1 reference

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Heuristic thinking and inference from observational epidemiology.

29 October 2018

1 reference

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Randomized trial of tamoxifen alone or combined with fluoxymesterone as adjuvant therapy in postmenopausal women with resected estrogen receptor positive breast cancer. North Central Cancer Treatment Group Trial 89-30-52.

29 October 2018

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Molecular characterization of the microsomal tamoxifen binding site

29 October 2018

1 reference

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Tamoxifen and metabolite concentrations in serum and breast cancer tissue during three dose regimens in a randomized preoperative trial.

29 October 2018

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Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine

29 October 2018

1 reference

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A randomized trial of low-dose tamoxifen on breast cancer proliferation and blood estrogenic biomarkers

29 October 2018

1 reference

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Polymorphism in the CYP2D6 Tamoxifen-Metabolizing Gene Influences Clinical Effect but Not Hot Flashes: Data From the Italian Tamoxifen Trial

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895727

Tamoxifen metabolites in patients on long-term adjuvant therapy for breast cancer

29 October 2018

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12 December 2020

Effect of oestrogen receptor status and time on the intra-tumoural accumulation of tamoxifen and N-desmethyltamoxifen following short-term therapy in human primary breast cancer

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12 December 2020

Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer

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12 December 2020

Pharmacokinetics/genotype associations for major cytochrome P450 enzymes in native and first- and third-generation Japanese populations: comparison with Korean, Chinese, and Caucasian populations

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12 December 2020

Re: Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine

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12 December 2020

Endogenous concentration and subcellular distribution of estrogens in normal and malignant human breast tissue

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12 December 2020

Identification of 4-hydroxy-N-desmethyltamoxifen as a metabolite of tamoxifen in human bile

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12 December 2020

Distribution of 4-hydroxy-N-desmethyltamoxifen and other tamoxifen metabolites in human biological fluids during tamoxifen treatment

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12 December 2020

Commentary: estimating direct and indirect effects-fallible in theory, but in the real world?

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970030-0

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1016/S1470-2045(09)70030-0

1 reference

30 July 2017

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30 July 2017

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