PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib (Q33933626)

30 July 2017

title

PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib (English)

1 reference

30 July 2017

1 reference

Leiping Wang

1 reference

30 July 2017

Qunling Zhang

1 reference

30 July 2017

Jian Zhang

1 reference

30 July 2017

Si Sun

1 reference

30 July 2017

Haiyi Guo

1 reference

30 July 2017

Zhen Jia

1 reference

30 July 2017

Biyun Wang

1 reference

30 July 2017

Zhimin Shao

1 reference

30 July 2017

Zhonghua Wang

1 reference

30 July 2017

Xichun Hu

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30 July 2017

language of work or name

English

0 references

publication date

15 June 2011

1 reference

full work available at URL

30 July 2017

https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-11-248

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21676217

https://europepmc.org/articles/PMC3141770

4 December 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21676217

https://europepmc.org/articles/PMC3141770?pdf=render

4 December 2024

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21676217

http://link.springer.com/content/pdf/10.1186/1471-2407-11-248.pdf

4 December 2024

1 reference

https://api.crossref.org/works/10.1186/1471-2407-11-248

http://link.springer.com/article/10.1186/1471-2407-11-248/fulltext.html

4 December 2024

1 reference

https://api.crossref.org/works/10.1186/1471-2407-11-248

http://link.springer.com/content/pdf/10.1186/1471-2407-11-248

4 December 2024

1 reference

https://api.crossref.org/works/10.1186/1471-2407-11-248

https://link.springer.com/content/pdf/10.1186/1471-2407-11-248.pdf

4 December 2024

1 reference

https://api.crossref.org/works/10.1186/1471-2407-11-248

4 December 2024

1 reference

30 July 2017

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30 July 2017

page(s)

248

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Loss of Phosphatase and Tensin Homolog or Phosphoinositol-3 Kinase Activation and Response to Trastuzumab or Lapatinib in Human Epidermal Growth Factor Receptor 2–Overexpressing Locally Advanced Breast Cancers

30 July 2017

cites work

1 reference

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The PI3 kinase/mTOR blocker NVP-BEZ235 overrides resistance against irreversible ErbB inhibitors in breast cancer cells.

5 July 2018

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PIK3CA Mutations May Be Discordant between Primary and Corresponding Metastatic Disease in Breast Cancer

5 July 2018

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5 July 2018

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Approaches and limitations of phosphatidylinositol-3-kinase pathway activation status as a predictive biomarker in the clinical development of targeted therapy

5 July 2018

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Resistance to HER2 inhibitors: is addition better than substitution? Rationale for the hypothetical concept of drug sedimentation

5 July 2018

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Activated phosphoinositide 3-kinase/AKT signaling confers resistance to trastuzumab but not lapatinib

5 July 2018

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Clinical benefit of lapatinib-based therapy in patients with human epidermal growth factor receptor 2-positive breast tumors coexpressing the truncated p95HER2 receptor.

5 July 2018

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Clinical significance of PTEN and p-Akt co-expression in HER2-positive metastatic breast cancer patients treated with trastuzumab-based therapies

5 July 2018

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Multiple molecular mechanisms underlying trastuzumab and lapatinib resistance in JIMT-1 breast cancer cells

5 July 2018

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Lapatinib monotherapy in patients with relapsed, advanced, or metastatic breast cancer: efficacy, safety, and biomarker results from Japanese patients phase II studies.

5 July 2018

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PIK3CA mutation associates with improved outcome in breast cancer.

5 July 2018

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Association between gain-of-function mutations in PIK3CA and resistance to HER2-targeted agents in HER2-amplified breast cancer cell lines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141770

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

5 July 2018

1 reference

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Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141770

Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer

5 July 2018

1 reference

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Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141770

Integrated profiling of basal and luminal breast cancers.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141770

A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141770

A new mutational AKTivation in the PI3K pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141770

Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141770

Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers

5 July 2018

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Lapatinib plus capecitabine for HER2-positive advanced breast cancer

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141770

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141770

Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141770

PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2-overexpressing breast cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141770

Oncogenic PI3K deregulates transcription and translation

5 July 2018

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Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer

5 July 2018

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Somatic mutation and gain of copy number of PIK3CA in human breast cancer

5 July 2018

1 reference

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PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141770

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141770

High frequency of mutations of the PIK3CA gene in human cancers

5 July 2018

1 reference

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Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer

5 July 2018

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Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

5 July 2018

1 reference

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The multiple roles of PTEN in tumor suppression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141770

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141770

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141770

5 July 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-11-248

Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-11-248

Phase II study of predictive biomarker profiles for response targeting human epidermal growth factor receptor 2 (HER-2) in advanced inflammatory breast cancer with lapatinib monotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-11-248

PIK3CA mutation and histological type in breast carcinoma: high frequency of mutations in lobular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-11-248

PIK3CA mutations in breast cancer are associated with poor outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-11-248

PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-11-248

Reduced expression of PTEN correlates with breast cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-11-248

Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-11-248

Neoadjuvant trastuzumab and docetaxel in breast cancer: preliminary results

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141770

Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women

29 October 2018

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12 December 2020

Different prognostic roles of mutations in the helical and kinase domains of the PIK3CA gene in breast carcinomas

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12 December 2020

PTEN promoter is methylated in a proportion of invasive breast cancers

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12 December 2020

Mutation of the PIK3CA gene in ovarian and breast cancer

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12 December 2020

Reduced PTEN expression is associated with poor outcome and angiogenesis in invasive ductal carcinoma of the breast

1 reference

12 December 2020

Breast cancer--loss of PTEN predicts resistance to treatment

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12 December 2020

Reduced expression of PTEN protein and its prognostic implications in invasive ductal carcinoma of the breast

1 reference

12 December 2020

Heterogeneous lack of expression of the tumour suppressor PTEN protein in human neoplastic tissues

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12 December 2020

Identifiers

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Dimensions Publication ID

30 July 2017

1 reference

https://scigraph.springernature.com/pub.10.1186/1471-2407-11-248

9 September 2019

1 reference

30 July 2017

1 reference