The initial substrate-binding site of gamma-secretase is located on presenilin near the active site (Q33927461)

30 July 2017

title

The initial substrate-binding site of gamma-secretase is located on presenilin near the active site (English)

1 reference

30 July 2017

Frédéric Bihel

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author name string

Anna Y Kornilova

1 reference

30 July 2017

Frédéric Bihel

1 reference

30 July 2017

Chittaranjan Das

1 reference

30 July 2017

Michael S Wolfe

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30 July 2017

language of work or name

English

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publication date

18 February 2005

1 reference

Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

published in

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30 July 2017

volume

102

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30 July 2017

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30 July 2017

page(s)

3230-3235

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Intramembrane proteolysis: theme and variations.

30 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552920

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552920

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552920

The role of presenilin cofactors in the gamma-secretase complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552920

Engineering exosite peptides for complete inhibition of factor VIIa using a protease switch with substrate phage

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552920

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552920

Identification of signal peptide peptidase, a presenilin-type aspartic protease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552920

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552920

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552920

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552920

A novel exosite on coagulation factor VIIa and its molecular interactions with a new class of peptide inhibitors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552920

A portrait of Alzheimer secretases--new features and familiar faces

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552920

The Role of presenilins in gamma-secretase activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552920

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552920

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552920

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552920

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552920

Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552920

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552920

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552920

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552920

Benzophenone photophores in biochemistry.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552920

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552920

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552920

Reconstitution of gamma-secretase activity

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0407640102

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0407640102

In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0407640102

Designed Helical Peptides Inhibit an Intramembrane Protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0407640102

Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0407640102

Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15722417

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15722417

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0407640102

1 reference

30 July 2017

0 references

1 reference

30 July 2017

1 reference