"Clocks" in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging (Q33915457)

30 July 2017

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title

"Clocks" in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging (English)

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30 July 2017

Shin-Ichiro Imai

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30 July 2017

language of work or name

English

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publication date

6 November 2009

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Biochimica et Biophysica Acta

30 July 2017

published in

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30 July 2017

volume

1804

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30 July 2017

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30 July 2017

page(s)

1584-1590

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Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes.

30 July 2017

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5 July 2018

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SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty

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Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis

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From heterochromatin islands to the NAD World: a hierarchical view of aging through the functions of mammalian Sirt1 and systemic NAD biosynthesis

5 July 2018

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Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1

5 July 2018

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5 July 2018

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5 July 2018

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The NAD World: a new systemic regulatory network for metabolism and aging--Sirt1, systemic NAD biosynthesis, and their importance

5 July 2018

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5 July 2018

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5 July 2018

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Physiological significance of a peripheral tissue circadian clock

5 July 2018

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5 July 2018

The meter of metabolism

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The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control

5 July 2018

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SIRT1 regulates circadian clock gene expression through PER2 deacetylation

5 July 2018

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Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt

5 July 2018

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The Sirtuin family: therapeutic targets to treat diseases of aging

5 July 2018

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Conserved metabolic regulatory functions of sirtuins

5 July 2018

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Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice

5 July 2018

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Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme

5 July 2018

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Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival

5 July 2018

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Sirtuins: the 'magnificent seven', function, metabolism and longevity

5 July 2018

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Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism

5 July 2018

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Sirtuins in mammals: insights into their biological function

5 July 2018

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The clockwork of metabolism

5 July 2018

1 reference

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A role of the circadian system and circadian proteins in aging.

5 July 2018

1 reference

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The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/visfatin in mammals

5 July 2018

1 reference

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Crystal structure of visfatin/pre-B cell colony-enhancing factor 1/nicotinamide phosphoribosyltransferase, free and in complex with the anti-cancer agent FK-866

5 July 2018

1 reference

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Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock

5 July 2018

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5 July 2018

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Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme.

5 July 2018

1 reference

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Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells

5 July 2018

1 reference

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Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity

5 July 2018

1 reference

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Living by the clock: the circadian pacemaker in older people

5 July 2018

1 reference

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Pre-B-cell colony-enhancing factor regulates NAD+-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Obesity and metabolic syndrome in circadian Clock mutant mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Calorie restriction, SIRT1 and metabolism: understanding longevity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

The Sir2 family of protein deacetylases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Enzymology of NAD+ homeostasis in man.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

The Drosophila melanogaster sir2+ gene is nonessential and has only minor effects on position-effect variegation.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Genetics and the specificity of the aging process

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

The endocrine regulation of aging by insulin-like signals

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Coordination of circadian timing in mammals

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Effects of aging on central and peripheral mammalian clocks.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Circadian rhythms from flies to human

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Identification of a plasmid-encoded gene from Haemophilus ducreyi which confers NAD independence

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

The hypothalamic-pituitary control of ageing and age-related pathology

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Circadian Rhythms in Drinking Behavior and Locomotor Activity of Rats Are Eliminated by Hypothalamic Lesions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Age-associated elevation of hypothalamic, threshold to feedback control, and its role in development, ageine, and disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Pellagra: A clue as to why energy failure causes diseases?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

Enzymatic synthesis of nicotinamide mononucleotide.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2886185

The circadian clock and tumor suppression by mammalian period genes

29 October 2018

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12 December 2020

SIRT1 markedly extends replicative lifespan if the NAD+ salvage pathway is enhanced

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12 December 2020

The suprachiasmatic nucleus and the circadian time-keeping system revisited

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12 December 2020

Extension of human cell lifespan by nicotinamide phosphoribosyltransferase

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12 December 2020

10.1016/J.BBAPAP.2009.10.024

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DOI

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30 July 2017

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30 July 2017

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