High-content drug screening with engineered musculoskeletal tissues (Q33835153)

29 July 2017

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title

High-content drug screening with engineered musculoskeletal tissues (English)

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29 July 2017

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Herman Vandenburgh

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29 July 2017

language of work or name

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1 February 2010

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Tissue Engineering Part B: Reviews

29 July 2017

published in

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29 July 2017

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29 July 2017

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29 July 2017

page(s)

55-64

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Zebrafish muscular disease models towards drug discovery

29 July 2017

cites work

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4 July 2018

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Microfabricated tissue gauges to measure and manipulate forces from 3D microtissues

4 July 2018

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Automated drug screening with contractile muscle tissue engineered from dystrophic myoblasts

4 July 2018

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Combined atomic force microscopy and side-view optical imaging for mechanical studies of cells

4 July 2018

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High-throughput and combinatorial technologies for tissue engineering applications

4 July 2018

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Proliferation and osteogenesis of immortalized bone marrow-derived mesenchymal stem cells in porous polylactic glycolic acid scaffolds under perfusion culture

4 July 2018

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High-throughput measurements of hydrogel tissue construct mechanics

4 July 2018

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Tissue engineered bone grafts: biological requirements, tissue culture and clinical relevance

4 July 2018

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Self-renewal and expansion of single transplanted muscle stem cells

4 July 2018

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4 July 2018

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High-throughput screening for modulators of mesenchymal stem cell chondrogenesis

4 July 2018

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4 July 2018

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Biomechanical analysis of structural deformation in living cells.

4 July 2018

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High-throughput screening of cell responses to biomaterials

4 July 2018

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Cell delivery mechanisms for tissue repair

4 July 2018

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Two-tiered hypotheses for Duchenne muscular dystrophy.

4 July 2018

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Microbioreactors for high-throughput cytotoxicity assays.

4 July 2018

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Target deconvolution strategies in drug discovery

4 July 2018

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Engineering tumors with 3D scaffolds

4 July 2018

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Functional tissue engineering for tendon repair: A multidisciplinary strategy using mesenchymal stem cells, bioscaffolds, and mechanical stimulation

4 July 2018

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Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin-dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophies

4 July 2018

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Engineering complex tissues

4 July 2018

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Bespoke human hypertrophic chondrocytic cell lines provide the osteoinductive signals required for vascularized bone formation.

4 July 2018

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Engineered tissue as a model to study cell and tissue function from a biophysical perspective.

4 July 2018

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Stem and progenitor cells in skeletal muscle development, maintenance, and therapy

4 July 2018

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Bioprocessing of embryonic stem cells for drug discovery

4 July 2018

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Zebrafish orthologs of human muscular dystrophy genes

4 July 2018

1 reference

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Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states

4 July 2018

1 reference

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Mechanotransduction in skeletal muscle

4 July 2018

1 reference

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Cellular caspase-8-like inhibitory protein (cFLIP) prevents inhibition of muscle cell differentiation induced by cancer cells

4 July 2018

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Translating mighty mice into neuromuscular therapeutics: is bigger muscle better?

4 July 2018

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Tissue engineering for anterior cruciate ligament reconstruction: a review of current strategies

4 July 2018

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Regulating activation of transplanted cells controls tissue regeneration

4 July 2018

1 reference

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Microscale technologies for tissue engineering and biology

4 July 2018

1 reference

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A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction

4 July 2018

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Finding new tricks for old drugs: an efficient route for public-sector drug discovery

4 July 2018

1 reference

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Engineering myocardial tissue

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Tissue cells feel and respond to the stiffness of their substrate

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Target-based drug discovery: is something wrong?

4 July 2018

1 reference

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Drug repositioning: identifying and developing new uses for existing drugs

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Tissue engineering of ligaments

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Phenotypic screening for pharmaceuticals using tissue constructs

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Selective optimization of side activities: another way for drug discovery

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

A novel cell-based system for evaluating skeletal muscle cell hypertrophy-inducing agents

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Skeletal tissue engineering-from in vitro studies to large animal models

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Signalling pathways that mediate skeletal muscle hypertrophy and atrophy

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Tissue engineering--current challenges and expanding opportunities

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Tissue engineering of a differentiated cardiac muscle construct

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Identification of ubiquitin ligases required for skeletal muscle atrophy

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Aminoglycoside antibiotics restore dystrophin function to skeletal muscles of mdx mice

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Skeletal muscle hypertrophy is mediated by a Ca2+-dependent calcineurin signalling pathway

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Space travel directly induces skeletal muscle atrophy.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Dystrophin-glycoprotein complex: its role in the molecular pathogenesis of muscular dystrophies.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Myogenic cell lines derived from transgenic mice carrying a thermolabile T antigen: a model system for the derivation of tissue-specific and mutation-specific cell lines

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro

4 July 2018

1 reference

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Drug discovery. Repurposing with a difference.

4 July 2018

1 reference

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Evaluation criteria for musculoskeletal and craniofacial tissue engineering constructs: a conference report

29 October 2018

1 reference

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Establishment of Periodontal Ligament Cell Lines from Temperature-Sensitive Simian Virus 40 Large T-antigen Transgenic Rats

29 October 2018

1 reference

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Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1.

29 October 2018

1 reference

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Drug-screening platform based on the contractility of tissue-engineered muscle.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Microscale culture of human liver cells for drug development

29 October 2018

1 reference

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Scaffold-free three-dimensional cell culture utilizing micromolded nonadhesive hydrogels

29 October 2018

1 reference

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Microfluidic scaffolds for tissue engineering

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Muscular thin films for building actuators and powering devices

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Embryonic stem cells as a source of models for drug discovery

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

A defined system to allow skeletal muscle differentiation and subsequent integration with silicon microstructures

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Nutritional therapy improves function and complements corticosteroid intervention in mdx mice

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Prednisone reduces muscle degeneration in dystrophin-deficient Caenorhabditis elegans

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Zebrafish: a preclinical model for drug screening

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

p38 MAP kinase signalling is required for hypertrophic chondrocyte differentiation

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

Glucocorticoid-mediated regulation of utrophin levels in human muscle fibers

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865990

An assessment of statin safety by muscle experts

29 October 2018

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12 December 2020

Insulin and IGF-I induce pronounced hypertrophy of skeletal myofibers in tissue culture

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12 December 2020

Excitability and contractility of skeletal muscle engineered from primary cultures and cell lines

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12 December 2020

Evaluation of cellular affinity and compatibility to biodegradable polyesters and Type-II collagen-modified scaffolds using immortalized rat chondrocytes

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12 December 2020

Mechanical stimulation improves tissue-engineered human skeletal muscle

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12 December 2020

Computer-aided mechanogenesis of skeletal muscle organs from single cells in vitro

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12 December 2020

In Vitro Model for Stretch-Induced Hypertrophy of Skeletal Muscle

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12 December 2020

Pre-clinical screening of drugs using the mdx mouse

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12 December 2020

Screening for content--the evolution of high throughput

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12 December 2020

A simplified method for tissue engineering skeletal muscle organoids in vitro

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12 December 2020

iPS cell technology gains momentum in drug discovery

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12 December 2020

10.1089/TEN.TEB.2009.0445

Identifiers

DOI

1 reference

release_gskhe733kje3xdw54zcrm7int4

29 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/gskhe733kje3xdw54zcrm7int4

24 November 2022

mapped directly with Wikidata item

PMC publication ID

2865990

1 reference

29 July 2017

1 reference