Enzymes of parasite thiol metabolism as drug targets (Q33730332)

29 July 2017

title

Enzymes of parasite thiol metabolism as drug targets (English)

1 reference

29 July 2017

Krauth-Siegel RL

1 reference

29 July 2017

Coombs GH

series ordinal

1 reference

29 July 2017

publication date

1 October 1999

1 reference

29 July 2017

published in

Trends in Parasitology

1 reference

29 July 2017

1 reference

29 July 2017

1 reference

29 July 2017

page(s)

404-409

1 reference

Metabolism and functions of trypanothione in the Kinetoplastida

29 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Reduction of dehydroascorbate by trypanothione

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

A Unique Cascade of Oxidoreductases Catalyses Trypanothione-Mediated Peroxide Metabolism in Crithidia fasciculata

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Catalytic Characteristics of Tryparedoxin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Sequence, heterologous expression and functional characterization of a novel tryparedoxin from Crithidia fasciculata

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Identification and characterisation of a functional peroxidoxin from Leishmania major

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Trypanosoma brucei tryparedoxin, a thioredoxin-like protein in African trypanosomes.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Efflux systems and increased trypanothione levels in arsenite-resistant Leishmania

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Co-amplification of the gamma-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene pgpA in arsenite-resistant Leishmania tarentolae.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Inducible gene expression in trypanosomes mediated by a prokaryotic repressor.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Polyamine derivatives as inhibitors of trypanothione reductase and assessment of their trypanocidal activities

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Inhibition of Trypanosoma cruzi trypanothione reductase by crystal violet

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Crystal structure of the Trypanosoma cruzi trypanothione reductase.mepacrine complex

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Charge is the major discriminating factor for glutathione reductase versus trypanothione reductase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

2-Amino diphenylsulfides as new inhibitors of trypanothione reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Substrate interactions between trypanothione reductase and N1-glutathionylspermidine disulphide at 0.28-nm resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Disulfide-Reductase Inhibitors as Chemotherapeutic Agents: The Design of Drugs for Trypanosomiasis and Malaria

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Cloning, sequencing and functional expression of dihydrolipoamide dehydrogenase from the human pathogen Trypanosoma cruzi

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Nitrofuran drugs as common subversive substrates of Trypanosoma cruzi lipoamide dehydrogenase and trypanothione reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Phosphonic acid and phosphinic acid tripeptides as inhibitors of glutathionylspermidine synthetase

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

The Malaria Parasite Supplies Glutathione to its Host Cell — Investigation of Glutathione Transport and Metabolism in Human Erythrocytes Infected with Plasmodium Falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Plasmodium falciparum glutathione metabolism and growth are independent of glutathione system of host erythrocyte

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Glutathione reductase-deficient erythrocytes as host cells of malarial parasites

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Recombinant Plasmodium falciparum glutathione reductase is inhibited by the antimalarial dye methylene blue

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Plasmodium berghei: implication of intracellular glutathione and its related enzyme in chloroquine resistance in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

The putative gamma-glutamylcysteine synthetase from Plasmodium falciparum contains large insertions and a variable tandem repeat

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase from Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Identification and Characterization of the Functional Amino Acids at the Active Site of the Large Thioredoxin Reductase fromPlasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

The role of the C-terminus for catalysis of the large thioredoxin reductase from Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Thioredoxin reductase from Plasmodium falciparum: evidence for interaction between the C-terminal cysteine residues and the active site disulfide-dithiol

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Recombinant putative glutathione reductase of Plasmodium falciparum exhibits thioredoxin reductase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Conservation of gene order: a fingerprint of proteins that physically interact

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

Recent advances in identifying and validating drug targets in trypanosomes and leishmanias.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-4758%2899%2901516-1

7 January 2021

10.1016/S0169-4758(99)01516-1

Identifiers

DOI

1 reference

29 July 2017

1 reference