Modified vaccinia Ankara expressing survivin combined with gemcitabine generates specific antitumor effects in a murine pancreatic carcinoma model. (Q33723063)

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English	Modified vaccinia Ankara expressing survivin combined with gemcitabine generates specific antitumor effects in a murine pancreatic carcinoma model.	scientific article

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15 February 2020

Modified vaccinia Ankara expressing survivin combined with gemcitabine generates specific antitumor effects in a murine pancreatic carcinoma model (English)

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15 February 2020

pancreatic carcinoma

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15 February 2020

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Hidenobu Ishizaki

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15 February 2020

Edwin R Manuel

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15 February 2020

Guang-Yun Song

3

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15 February 2020

Tumul Srivastava

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15 February 2020

Sabrina Sun

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15 February 2020

Joshua D I Ellenhorn

7

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15 February 2020

publication date

20 October 2010

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15 February 2020

Cancer Immunology, Immunotherapy

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15 February 2020

60

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15 February 2020

1

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15 February 2020

99-109

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15 February 2020

Heterologous prime/boost immunization with p53-based vaccines combined with toll-like receptor stimulation enhances tumor regression.

1 reference

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21 June 2018

Intergenic region 3 of modified vaccinia ankara is a functional site for insert gene expression and allows for potent antigen-specific immune responses

1 reference

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21 June 2018

Antiangiogenic versus cytotoxic therapeutic approaches in a mouse model of pancreatic cancer: an experimental study with a multitarget tyrosine kinase inhibitor (sunitinib), gemcitabine and radiotherapy

1 reference

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21 June 2018

Cancer statistics, 2009

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21 June 2018

The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies

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21 June 2018

Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer

1 reference

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21 June 2018

Cancer cells survive with survivin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289969

21 June 2018

A combination of chemoimmunotherapies can efficiently break self-tolerance and induce antitumor immunity in a tolerogenic murine tumor model

1 reference

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21 June 2018

Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group

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21 June 2018

An MVA vaccine overcomes tolerance to human p53 in mice and humans

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21 June 2018

Immunosuppressive strategies that are mediated by tumor cells

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21 June 2018

Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function

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21 June 2018

Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells

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21 June 2018

Vaccination of colorectal cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax) induces immune responses which correlate with disease control: a phase I/II trial

1 reference

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21 June 2018

Targeted therapy by disabling crossroad signaling networks: the survivin paradigm

1 reference

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21 June 2018

Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppression

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21 June 2018

Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289969

21 June 2018

Downregulation of survivin by siRNA diminishes radioresistance of pancreatic cancer cells.

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21 June 2018

Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289969

21 June 2018

A DNA vaccine targeting survivin combines apoptosis with suppression of angiogenesis in lung tumor eradication

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21 June 2018

Two distinct pathways of immuno-modulation improve potency of p53 immunization in rejecting established tumors.

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21 June 2018

Attenuated poxviruses generate clinically relevant frequencies of CMV-specific T cells.

1 reference

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21 June 2018

Pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289969

21 June 2018

All-trans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination.

1 reference

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21 June 2018

Generation of cytotoxic responses in mice and human individuals against hematological malignancies using survivin-RNA-transfected dendritic cells.

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21 June 2018

CTLA-4 blockade enhances the therapeutic effect of an attenuated poxvirus vaccine targeting p53 in an established murine tumor model

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21 June 2018

Expression of survivin, a novel inhibitor of apoptosis and cell cycle regulatory protein, in pancreatic adenocarcinoma

1 reference

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21 June 2018

Tumor cell lysate-pulsed human dendritic cells induce a T-cell response against pancreatic carcinoma cells: an in vitro model for the assessment of tumor vaccines

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21 June 2018

Resected adenocarcinoma of the pancreas-616 patients: results, outcomes, and prognostic indicators

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21 June 2018

Molecular basis of T cell-mediated recognition of pancreatic cancer cells

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21 June 2018

Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation

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21 June 2018

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

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21 June 2018

Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial

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21 June 2018

Induction and chemotherapeutic response of two transplantable ductal adenocarcinomas of the pancreas in C57BL/6 mice.

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21 June 2018

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen-Reactivity

1 reference

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21 June 2018

Effect of gemcitabine on immune cells in subjects with adenocarcinoma of the pancreas

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21 January 2018

Induction of tumor cell apoptosis in vivo increases tumor antigen cross-presentation, cross-priming rather than cross-tolerizing host tumor-specific CD8 T cells

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21 January 2018

High frequencies of functional tumor-reactive T cells in bone marrow and blood of pancreatic cancer patients

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21 January 2018

Survivin, cancer networks and pathway-directed drug discovery.

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Analysis of human transcriptomes.

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21 January 2018

Mechanism of immune dysfunction in cancer mediated by immature Gr-1+ myeloid cells

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Synergy between chemotherapy and immunotherapy in the treatment of established murine solid tumors

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30 October 2018

Antibody response to the tumor-associated inhibitor of apoptosis protein survivin in cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20960189

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of survivin is correlated with cancer cell apoptosis and is involved in the development of human pancreatic duct cell tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20960189

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spontaneous cytotoxic T-cell responses against survivin-derived MHC class I-restricted T-cell epitopes in situ as well as ex vivo in cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20960189

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD8+ tumor-infiltrating lymphocytes together with CD4+ tumor-infiltrating lymphocytes and dendritic cells improve the prognosis of patients with pancreatic adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20960189

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Patterns of failure after curative resection of pancreatic carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20960189

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recurrence after resection for ductal adenocarcinoma of the pancreas

1 reference

https://pubmed.ncbi.nlm.nih.gov/20960189

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Weekly short infusions of gemcitabine are not associated with suppression of lymphatic activity in patients with solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20960189

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoregulation in pancreatic cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20960189

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00262-010-0923-0

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15 February 2020

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15 February 2020

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15 February 2020

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