Technology Insight: novel imaging of molecular targets is an emerging area crucial to the development of targeted drugs (Q33696408)

28 July 2017

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title

Technology Insight: novel imaging of molecular targets is an emerging area crucial to the development of targeted drugs (English)

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28 July 2017

Wolfgang A Weber

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28 July 2017

Johannes Czernin

series ordinal

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28 July 2017

Michael E Phelps

series ordinal

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28 July 2017

Harvey R Herschman

series ordinal

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28 July 2017

publication date

1 January 2008

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Nature Clinical Practice Oncology

28 July 2017

published in

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28 July 2017

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28 July 2017

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28 July 2017

page(s)

44-54

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PET/CT: form and function

28 July 2017

cites work

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Early tumor response to Hsp90 therapy using HER2 PET: comparison with 18F-FDG PET

28 July 2018

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28 July 2018

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28 July 2018

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The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations.

28 July 2018

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28 July 2018

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Looking and listening to light: the evolution of whole-body photonic imaging

28 July 2018

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28 July 2018

Targeted cancer therapy

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Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals

28 July 2018

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In vivo cancer targeting and imaging with semiconductor quantum dots

28 July 2018

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Positron emission tomography microdosing: a new concept with application in tracer and early clinical drug development

28 July 2018

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Kinetic modeling of 5-fluorouracil anabolism in colorectal adenocarcinoma: a positron emission tomography study in rats.

28 July 2018

1 reference

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Pharmacokinetics of radiolabelled anticancer drugs for positron emission tomography

28 July 2018

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Noninvasive imaging of protein-protein interactions in living subjects by using reporter protein complementation and reconstitution strategies

28 July 2018

1 reference

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Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830564

Biokinetics and imaging with the somatostatin receptor PET radioligand (68)Ga-DOTATOC: preliminary data

28 July 2018

1 reference

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In vivo molecular target assessment of matrix metalloproteinase inhibition

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830564

Pharmacokinetic evaluation of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in patients by positron emission tomography

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830564

Breast cancer: PET imaging of estrogen receptors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830564

A model for prediction of chemotherapy response to 5-fluorouracil based on the differential distribution of 5-[18F]fluorouracil in sensitive versus resistant lymphocytic leukemia in mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830564

Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probes

28 July 2018

1 reference

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Monitoring tumor glucose utilization by positron emission tomography for the prediction of treatment response to epidermal growth factor receptor kinase inhibitors

30 October 2018

1 reference

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Molecular imaging of EGFR kinase activity in tumors with 124I-labeled small molecular tracer and positron emission tomography.

30 October 2018

1 reference

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Positron emission tomography as an imaging biomarker

30 October 2018

1 reference

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Indium-111-labeled trastuzumab scintigraphy in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer.

30 October 2018

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Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics

30 October 2018

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Arming antibodies: prospects and challenges for immunoconjugates

30 October 2018

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Biodistribution and pharmacokinetics of the alphavbeta3-selective tracer 18F-galacto-RGD in cancer patients

30 October 2018

1 reference

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Imaging proliferation in brain tumors with 18F-FLT PET: comparison with 18F-FDG.

30 October 2018

1 reference

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Phase I study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of PTK787/ZK 222584 administered twice daily in patients with advanced cancer

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830564

First (18)F-labeled tracer suitable for routine clinical imaging of sst receptor-expressing tumors using positron emission tomography

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830564

Imaging the pharmacodynamics of HER2 degradation in response to Hsp90 inhibitors

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830564

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830564

Tumor localization of 16beta-18F-fluoro-5alpha-dihydrotestosterone versus 18F-FDG in patients with progressive, metastatic prostate cancer

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830564

Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830564

Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for the pharmacological response of PTK787/ZK 222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases, in patients with advanced colorectal cancer a

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830564

Metabolic activation of temozolomide measured in vivo using positron emission tomography

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830564

Use of positron emission tomography in oncology and its potential role to assess response to imatinib mesylate therapy in gastrointestinal stromal tumors (GISTs).

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830564

In vivo validation of 3'deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) as a proliferation imaging tracer in humans: correlation of [(18)F]FLT uptake by positron emission tomography with Ki-67 immunohistochemistry and flow cytometry in human lung tumor

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830564

Noninvasive imaging of alpha(v)beta3 integrin expression using 18F-labeled RGD-containing glycopeptide and positron emission tomography

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830564

Positron emission tomographic assessment of "metabolic flare" to predict response of metastatic breast cancer to antiestrogen therapy.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830564

Quantitative fluoroestradiol positron emission tomography imaging predicts response to endocrine treatment in breast cancer

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18097456

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Fluorescence molecular tomography resolves protease activity in vivo

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18097456

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Molecular Imaging and Biological Evaluation of HuMV833 Anti-VEGF Antibody: Implications for Trial Design of Antiangiogenic Antibodies

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18097456

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCPONC0982

1 reference

28 July 2017

1 reference

28 July 2017

1 reference