Two faces of TGF-beta1 in breast cancer (Q33661529)

28 July 2017

1 reference

4 November 2020

Two faces of TGF-beta1 in breast cancer (English)

1 reference

transforming growth factor beta 1

28 July 2017

1 reference

4 November 2020

1 reference

neoplastic gene expression regulation

20 November 2019

1 reference

4 November 2020

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24891760%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

author name string

Joanna Magdalena Zarzynska

series ordinal

1 reference

24891760

28 July 2017

publication date

7 May 2014

7 references

Mediators of Inflammation

28 July 2017

13 March 2019

3 April 2019

17 June 2019

8 September 2019

20 November 2019

4 November 2020

7 references

13 March 2019

3 April 2019

17 June 2019

8 September 2019

20 November 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24891760%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

4 November 2020

2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24891760%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

page(s)

141747

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24891760%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 3.0 Unported

6 June 2020

6 references

13 March 2019

3 April 2019

17 June 2019

8 September 2019

20 November 2019

on focus list of Wikimedia project

4 November 2020

copyrighted

0 references

ScienceSource

0 references

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The relevance of the TGF-β Paradox to EMT-MET programs

21 June 2018

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Characterization of spontaneous and TGF-β-induced cell motility of primary human normal and neoplastic mammary cells in vitro using novel real-time technology

21 June 2018

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21 June 2018

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TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer

21 June 2018

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21 June 2018

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TGF-β upregulates miR-181a expression to promote breast cancer metastasis

21 June 2018

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21 June 2018

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21 June 2018

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TGFβ signalling in context

21 June 2018

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TGF-β/Smad signaling in kidney disease.

21 June 2018

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Complexities of TGF-β targeted cancer therapy

21 June 2018

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Mesenchymal stem cells play a potential role in regulating the establishment and maintenance of epithelial-mesenchymal transition in MCF7 human breast cancer cells by paracrine and induced autocrine TGF-β.

21 June 2018

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Pathway analyses identify TGFBR2 as potential breast cancer susceptibility gene: results from a consortium study among Asians

21 June 2018

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TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion

21 June 2018

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The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer.

21 June 2018

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Role of TGF-β and the tumor microenvironment during mammary tumorigenesis

21 June 2018

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TGF-β1 modulates the homeostasis between MMPs and MMP inhibitors through p38 MAPK and ERK1/2 in highly invasive breast cancer cells

21 June 2018

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21 June 2018

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MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-κB and TGF-β signaling pathways.

21 June 2018

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The roles of TGF-β signaling in carcinogenesis and breast cancer metastasis

21 June 2018

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21 June 2018

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21 June 2018

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Transforming growth factor-β signaling in tumor initiation, progression and therapy in breast cancer: an update

21 June 2018

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The Functional Crosstalk between HER2 Tyrosine Kinase and TGF-β Signaling in Breast Cancer Malignancy

21 June 2018

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21 June 2018

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When tumor suppressor TGFβ meets the HER2 (ERBB2) oncogene

21 June 2018

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Noncanonical TGF-β Signaling During Mammary Tumorigenesis

21 June 2018

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An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition

21 June 2018

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Chemical modulators of autophagy as biological probes and potential therapeutics

21 June 2018

1 reference

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Homeoprotein Six1 Increases TGF-β Type I Receptor and Converts TGF-β Signaling from Suppressive to Supportive for Tumor Growth

21 June 2018

1 reference

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The dynamic roles of TGF-β in cancer

21 June 2018

1 reference

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The TGF-β/Smad pathway induces breast cancer cell invasion through the up-regulation of matrix metalloproteinase 2 and 9 in a spheroid invasion model system

21 June 2018

1 reference

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TGF- Biology in Mammary Development and Breast Cancer

21 June 2018

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Oncosuppressive functions of autophagy

21 June 2018

1 reference

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Regulation of TGF-beta signalling by protein phosphatases

21 June 2018

1 reference

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TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression

21 June 2018

1 reference

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Targeting the Transforming Growth Factor-beta pathway inhibits human basal-like breast cancer metastasis.

21 June 2018

1 reference

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The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells

21 June 2018

1 reference

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Mechanisms of motility in metastasizing cells

21 June 2018

1 reference

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Doxorubicin in combination with a small TGFbeta inhibitor: a potential novel therapy for metastatic breast cancer in mouse models

21 June 2018

1 reference

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Targeting the transforming growth factor-beta signalling pathway in metastatic cancer

21 June 2018

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Inhibitory effect of a TGFbeta receptor type-I inhibitor, Ki26894, on invasiveness of scirrhous gastric cancer cells

21 June 2018

1 reference

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Transforming growth factor beta (TGF-beta) and inflammation in cancer

21 June 2018

1 reference

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Targeting the transforming growth factor-beta signaling pathway in human cancer

21 June 2018

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Global trends in breast cancer incidence and mortality.

21 June 2018

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Autophagy is activated by TGF-beta and potentiates TGF-beta-mediated growth inhibition in human hepatocellular carcinoma cells.

21 June 2018

1 reference

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Mechanisms of the epithelial-mesenchymal transition by TGF-beta

21 June 2018

1 reference

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A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition

21 June 2018

1 reference

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Autophagy in disease: a double-edged sword with therapeutic potential

21 June 2018

1 reference

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Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Matrix metalloproteinase-2 involvement in breast cancer progression: a mini-review.

21 June 2018

1 reference

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EMT, the cytoskeleton, and cancer cell invasion

21 June 2018

1 reference

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TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch

21 June 2018

1 reference

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Roles of TGFbeta in metastasis

21 June 2018

1 reference

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Transforming growth factor-beta signaling: emerging stem cell target in metastatic breast cancer?

21 June 2018

1 reference

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MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA

21 June 2018

1 reference

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Bone morphogenetic protein signaling enhances invasion and bone metastasis of breast cancer cells through Smad pathway

21 June 2018

1 reference

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21 June 2018

1 reference

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No association of TGFB1 L10P genotypes and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a multi-center cohort study

21 June 2018

1 reference

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An anti-transforming growth factor beta antibody suppresses metastasis via cooperative effects on multiple cell compartments.

21 June 2018

1 reference

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LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis

21 June 2018

1 reference

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Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment

21 June 2018

1 reference

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Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis

21 June 2018

1 reference

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Induction of autophagy during extracellular matrix detachment promotes cell survival

21 June 2018

1 reference

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Concordant epigenetic silencing of transforming growth factor-beta signaling pathway genes occurs early in breast carcinogenesis.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-beta kinase antagonist, in mice

21 June 2018

1 reference

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Tumour invasion and metastasis initiated by microRNA-10b in breast cancer

21 June 2018

1 reference

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Transforming growth factor-beta and the immune response: implications for anticancer therapy

21 June 2018

1 reference

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TAK1 is required for TGF-beta 1-mediated regulation of matrix metalloproteinase-9 and metastasis.

21 June 2018

1 reference

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Role of autophagy in breast cancer

21 June 2018

1 reference

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Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Transforming growth factor-beta signaling in breast cancer

21 June 2018

1 reference

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Genetic determinants of cancer metastasis

21 June 2018

1 reference

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Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Molecular definition of breast tumor heterogeneity

21 June 2018

1 reference

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Apoptosis and autophagy in mammary gland remodeling and breast cancer chemotherapy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

The type III TGF-beta receptor suppresses breast cancer progression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Ki26894, a novel transforming growth factor-beta type I receptor kinase inhibitor, inhibits in vitro invasion and in vivo bone metastasis of a human breast cancer cell line.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Development of oncolytic adenovirus armed with a fusion of soluble transforming growth factor-beta receptor II and human immunoglobulin Fc for breast cancer therapy

21 June 2018

1 reference

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Transforming growth factor-beta in cancer and metastasis

21 June 2018

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A novel functional polymorphism in the transforming growth factor-beta2 gene promoter and tumor progression in breast cancer

21 June 2018

1 reference

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Autophagy signaling and the cogwheels of cancer

21 June 2018

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Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-beta type I receptor kinase inhibitor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Matrix metalloproteinases and tumor metastasis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Paradoxical roles of the immune system during cancer development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Inhibition of TGFbeta signaling in cancer therapy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Alterations in components of the TGF-beta superfamily signaling pathways in human cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Non-Smad TGF-beta signals

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

TGF-beta 1 attenuates the acquisition and expression of effector function by tumor antigen-specific human memory CD8 T cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Gene amplification is a mechanism of Six1 overexpression in breast cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Duel nature of TGF-beta signaling: tumor suppressor vs. tumor promoter

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

TGF-beta-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERK signaling in MCF10A human breast epithelial cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Transgenic Mice Expressing a Dominant-Negative Mutant Type II Transforming Growth Factor-β Receptor Exhibit Impaired Mammary Development and Enhanced Mammary Tumor Formation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

TGF-beta-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Growth factor involvement in the multihormonal regulation of MCF-7 breast cancer cell growth in soft agar

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Transforming growth factor beta1 (TGFβ1) polymorphisms and breast cancer risk

21 June 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F141747

Transforming growth factor beta receptor type I and transforming growth factor beta1 polymorphisms are not associated with postmenopausal breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F141747

The L10P polymorphism of the transforming growth factor-beta 1 gene is not associated with breast cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F141747

Genetic polymorphisms of the transforming growth factor-beta1 gene and breast cancer risk: a possible dual role at different cancer stages

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F141747

Differentiation plasticity regulated by TGF-beta family proteins in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F141747

Autocrine TGF-β protects breast cancer cells from apoptosis through reduction of BH3-only protein, Bim.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F141747

Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F141747

Reversal of tamoxifen resistance of human breast carcinomas in vivo by neutralizing antibodies to transforming growth factor-beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F141747

Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F141747

A transforming growth factorbeta1 signal peptide variant increases secretion in vitro and is associated with increased incidence of invasive breast cancer.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Soluble type II transforming growth factor-beta receptor attenuates expression of metastasis-associated genes and suppresses pancreatic cancer cell metastasis.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033515

Regulation of autophagy by transforming growth factor-β (TGF-β) signaling

30 October 2018

1 reference

12 December 2020

Screening of circulating TGF-β levels and its clinicopathological significance in human breast cancer

1 reference

12 December 2020

Clinical significance of matrix metalloproteinase 2 and 9 in breast cancer

1 reference

12 December 2020

Matrix metalloproteinase expression and outcome in patients with breast cancer: analysis of a published database

1 reference

12 December 2020

TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinase

1 reference

12 December 2020

Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-beta1 expression

1 reference

12 December 2020

Identifiers

DOI

10.1155/2014/141747

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24891760%20AND%20SRC:MED&resulttype=core&format=json

release_sr6om2kzq5asdgjocyu34tapn4

6 June 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/sr6om2kzq5asdgjocyu34tapn4

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24891760%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

24891760

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24891760%20AND%20SRC:MED&resulttype=core&format=json