Molecular mechanisms of action of bisphosphonates. (Q33632255)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

review article

1 reference

title

Molecular mechanisms of action of bisphosphonates (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

Robert Graham G Russell

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

J C Frith

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

S P Luckman

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

F P Coxon

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

H L Benford

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

J Mönkkönen

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

S Auriola

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

K M Chilton

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

publication date

1 May 1999

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

issue

5 Suppl

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

page(s)

73S-79S

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json

The acute-phase response after bisphosphonate administration

7 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Identification of adenine nucleotide-containing metabolites of bisphosphonate drugs using ion-pair liquid chromatography-electrospray mass spectrometry.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Alendronate distributed on bone surfaces inhibits osteoclastic bone resorption in vitro and in experimental hypercalcemia models

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Bisphosphonates directly inhibit the bone resorption activity of isolated avian osteoclasts in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

The bisphosphonate tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

The management of Paget's disease of bone

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

The effect of several diphosphonates on acid phosphohydrolases and other lysosomal enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Dichloromethylenebisphosphonate (Cl2MBP) inhibits bone resorption through injury to osteoclasts that resorb Cl2MBP-coated bone

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Bisphosphonates. Pharmacology and use in the treatment of tumour-induced hypercalcaemic and metastatic bone disease

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

The inhibitory effect of phosphonates on the formation of calcium phosphate crystals in vitro and on aortic and kidney calcification in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Effect of pyrophosphate on hydroxyapatite and its implications in calcium homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5'-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Inhibition of osteoclast-like cell formation by bisphosphonates in long-term cultures of human bone marrow.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Effects of four bisphosphonates on bone resorption, lysosomal enzyme release, protein synthesis and mitotic activities in mouse calvarial bones in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. The Alendronate Phase III Osteoporosis Treatment Study Group

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Migration and phenotypic transformation of osteoclast precursors into mature osteoclasts: the effect of a bisphosphonate.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: evidence from structure-activity relationships in J774 macrophages.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Protein prenylation: a mediator of protein-protein interactions

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Comparison of the distribution of 3H-alendronate and 3H-etidronate in rat and mouse bones

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Effects of tiludronate and ibandronate on the secretion of proinflammatory cytokines and nitric oxide from macrophages in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

A possible mechanism of the specific action of bisphosphonates on osteoclasts: tiludronate preferentially affects polarized osteoclasts having ruffled borders

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Tiludronate inhibits protein tyrosine phosphatase activity in osteoclasts.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Contrast between effects of aminobisphosphonates and non-aminobisphosphonates on collagen-induced arthritis in mice

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Bisphosphonates act on osteoblastic cells and inhibit osteoclast formation in mouse marrow cultures.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Conversion from farnesyl diphosphate synthase to geranylgeranyl diphosphate synthase by random chemical mutagenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Alendronate inhibition of protein-tyrosine-phosphatase-meg1

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Application of an in vitro model and a clinical protocol in the assessment of the potency of a new bisphosphonate

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Effect of liposomal and free bisphosphonates on the IL-1 beta, IL-6 and TNF alpha secretion from RAW 264 cells in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Bisphosphonates are incorporated into adenine nucleotides by human aminoacyl-tRNA synthetase enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Bisphosphonates induce apoptosis in mouse macrophage-like cells in vitro by a nitric oxide-independent mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Incorporation of bisphosphonates into adenine nucleotides by amoebae of the cellular slime mould Dictyostelium discoideum.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Metabolism of halogenated bisphosphonates by the cellular slime mould dictyostelium discoideum

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Inhibitory effects of bisphosphonates on growth of amoebae of the cellular slime mold Dictyostelium discoideum

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Inhibition of growth of Dictyostelium discoideum amoebae by bisphosphonate drugs is dependent on cellular uptake

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

The influence of pyrophosphate, condensed phosphates, phosphonates and other phosphate compounds on the dissolution of hydroxyapatite in vitro and on bone resorption induced by parathyroid hormone in tissue culture and in thyroparathyroidectomised r

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Bisphosphonates act on rat bone resorption through the mediation of osteoblasts

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Effects of bisphosphonates on isolated rat osteoclasts as examined by reflected light microscopy

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Interleukin-6 and tumor necrosis factor alpha levels after bisphosphonates treatment in vitro and in patients with malignancy

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Quantitative morphometric evaluation of the inhibitory activity of new aminobisphosphonates on bone resorption in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) and dichloromethylene diphosphonate (Cl 2 MDP) on the calcification and resorption of cartilage and bone in the tibial epiphysis and metaphysis of rats

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Interleukin-6 and the acute phase response during treatment of patients with Paget's disease with the nitrogen-containing bisphosphonate dimethylaminohydroxypropylidene bisphosphonate

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Structure-activity relationships of various bisphosphonates

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Bisphosphonates induce apoptosis in human myeloma cell lines: a novel anti-tumour activity.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Diphosphonates and Page's disease of bone.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Regulation of osteoclast function

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Structural requirements for bisphosphonate actions in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Bisphosphonates induce osteoblasts to secrete an inhibitor of osteoclast-mediated resorption

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Interaction between effects of parathyroid hormone and bisphosphonate on regulation of osteoclast activity by the osteoblast-like cell line UMR-106.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Rab GTPases in vesicular transport

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Protein prenylation: molecular mechanisms and functional consequences

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

Acid extrusion is induced by osteoclast attachment to bone. Inhibition by alendronate and calcitonin

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2899%2900070-8

7 January 2021

10.1016/S8756-3282(99)00070-8

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10321934%20AND%20SRC:MED&resulttype=core&format=json