Targeting MUC1-C is synergistic with bortezomib in downregulating TIGAR and inducing ROS-mediated myeloma cell death (Q33585280)

28 July 2017

title

Targeting MUC1-C is synergistic with bortezomib in downregulating TIGAR and inducing ROS-mediated myeloma cell death (English)

1 reference

28 July 2017

1 reference

Li Yin

1 reference

28 July 2017

Turner Kufe

series ordinal

1 reference

28 July 2017

David Avigan

series ordinal

1 reference

28 July 2017

Donald Kufe

series ordinal

1 reference

28 July 2017

language of work or name

English

0 references

publication date

14 March 2014

1 reference

28 July 2017

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28 July 2017

volume

123

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28 July 2017

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28 July 2017

page(s)

2997-3006

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Novel agents for multiple myeloma to overcome resistance in phase III clinical trials

28 July 2017

cites work

1 reference

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Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death

21 June 2018

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Targeting the insulin-like growth factor-1 receptor to overcome bortezomib resistance in preclinical models of multiple myeloma.

21 June 2018

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21 June 2018

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21 June 2018

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Inhibition of the MUC1-C oncoprotein induces multiple myeloma cell death by down-regulating TIGAR expression and depleting NADPH

21 June 2018

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Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells

21 June 2018

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21 June 2018

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Survival of human multiple myeloma cells is dependent on MUC1 C-terminal transmembrane subunit oncoprotein function

21 June 2018

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21 June 2018

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21 June 2018

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Direct targeting of the mucin 1 oncoprotein blocks survival and tumorigenicity of human breast carcinoma cells

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors

21 June 2018

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Oxidative stress by targeted agents promotes cytotoxicity in hematologic malignancies

21 June 2018

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Antioxidants reduce endoplasmic reticulum stress and improve protein secretion

21 June 2018

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Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes

21 June 2018

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21 June 2018

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MUC1 oncoprotein promotes growth and survival of human multiple myeloma cells

21 June 2018

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21 June 2018

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Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?

21 June 2018

1 reference

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The histone deacetylase inhibitor, PXD101, potentiates bortezomib-induced anti-multiple myeloma effect by induction of oxidative stress and DNA damage

21 June 2018

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Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells

21 June 2018

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ER stress triggers apoptosis by activating BH3-only protein Bim

21 June 2018

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Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma

21 June 2018

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21 June 2018

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Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy

21 June 2018

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Cancer specific Mucin-1 glycoforms are expressed on multiple myeloma.

21 June 2018

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TIGAR, a p53-inducible regulator of glycolysis and apoptosis

21 June 2018

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Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells

21 June 2018

1 reference

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Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

21 June 2018

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The mammalian unfolded protein response

21 June 2018

1 reference

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CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014842

Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014842

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014842

NF-kappa B as a therapeutic target in multiple myeloma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014842

The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014842

Muc-1 core protein is expressed on multiple myeloma cells and is induced by dexamethasone.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014842

IGF-1 gene-modified muscle-derived stem cells are resistant to oxidative stress via enhanced activation of IGF-1R/PI3K/AKT signaling and secretion of VEGF.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014842

Reactive oxygen species-dependent down-regulation of tumor suppressor genes PTEN, USP28, DRAM, TIGAR, and CYLD under oxidative stress

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014842

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014842

Redox homeostasis modulates the sensitivity of myeloma cells to bortezomib

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014842

No evidence of mutations of the PSMB5 (beta-5 subunit of proteasome) in a case of myeloma with clinical resistance to Bortezomib

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014842

The proteasome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cells

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4014842

Epithelial mucin-1 (MUC1) expression and MA5 anti-MUC1 monoclonal antibody targeting in multiple myeloma

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24632713

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Expression of MUC1 on myeloma cells and induction of HLA-unrestricted CTL against MUC1 from a multiple myeloma patient

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24632713

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

MUC1 (EMA) expressing plasma cells in bone marrow infiltrated by plasma cell myeloma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24632713

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1182/BLOOD-2013-11-539395

1 reference

28 July 2017

1 reference

28 July 2017

1 reference