Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors (Q33437383)

9 July 2018

title

Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors (English)

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9 July 2018

author name string

Muhammad S Beg

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9 July 2018

Andrew J Brenner

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9 July 2018

Jasgit Sachdev

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9 July 2018

Mitesh Borad

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9 July 2018

Yoon-Koo Kang

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9 July 2018

Jay Stoudemire

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9 July 2018

Susan Smith

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9 July 2018

Andreas G Bader

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9 July 2018

Sinil Kim

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9 July 2018

David S Hong

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9 July 2018

publication date

5 December 2016

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9 July 2018

Investigational New Drugs

published in

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9 July 2018

volume

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9 July 2018

issue

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9 July 2018

page(s)

180-188

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9 July 2018

Epigenetic Modulators and the New Immunotherapies

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14 July 2018

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PDL1 Regulation by p53 via miR-34

14 July 2018

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14 July 2018

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14 July 2018

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Increased microRNA-34b and -34c predominantly expressed in stromal tissues is associated with poor prognosis in human colon cancer

14 July 2018

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Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs

14 July 2018

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14 July 2018

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Systemic delivery of a miR34a mimic as a potential therapeutic for liver cancer

14 July 2018

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14 July 2018

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In-depth analysis shows synergy between erlotinib and miR-34a

14 July 2018

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Quantification of therapeutic miRNA mimics in whole blood from nonhuman primates

14 July 2018

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A phase 1 study of the BCL2-targeted deoxyribonucleic acid inhibitor (DNAi) PNT2258 in patients with advanced solid tumors

14 July 2018

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MicroRNA-34a enhances T cell activation by targeting diacylglycerol kinase ζ.

14 July 2018

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TP53-independent function of miR-34a via HDAC1 and p21(CIP1/WAF1.).

14 July 2018

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Synthetic miR-34a mimics as a novel therapeutic agent for multiple myeloma: in vitro and in vivo evidence.

14 July 2018

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miR-34 - a microRNA replacement therapy is headed to the clinic

14 July 2018

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Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy

14 July 2018

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miR-34a predicts survival of Ewing's sarcoma patients and directly influences cell chemo-sensitivity and malignancy

14 July 2018

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14 July 2018

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14 July 2018

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Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice

14 July 2018

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The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

14 July 2018

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The Promise of MicroRNA Replacement Therapy

14 July 2018

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Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34

14 July 2018

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MicroRNA profiling of BRCA1/2 mutation-carrying and non-mutation-carrying high-grade serous carcinomas of ovary

14 July 2018

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MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells

14 July 2018

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The miR-34 family in cancer and apoptosis

14 July 2018

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MicroRNAs: target recognition and regulatory functions

14 July 2018

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miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells

14 July 2018

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Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation

14 July 2018

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A microRNA component of the p53 tumour suppressor network

14 July 2018

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MicroRNA signatures in human cancers

14 July 2018

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Oncomirs - microRNAs with a role in cancer

14 July 2018

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MicroRNAs: genomics, biogenesis, mechanism, and function

14 July 2018

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14 July 2018

https://api.crossref.org/works/10.1007%2FS10637-016-0407-Y

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-016-0407-Y

Evidence linking CD44-positive cells and gemcitabine resistance in pancreatic cancer cells: need for further substantiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-016-0407-Y

MicroRNA Molecular Profiles Associated with Diagnosis, Clinicopathologic Criteria, and Overall Survival in Patients with Resectable Pancreatic Ductal Adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-016-0407-Y

Systemic microRNA-34a delivery induces apoptosis and abrogates growth of diffuse large B-cell lymphoma in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-016-0407-Y

A qRT-PCR Method for Determining the Biodistribution Profile of a miR-34a Mimic

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-016-0407-Y

miR-34c is downregulated in prostate cancer and exerts tumor suppressive functions

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27917453

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S10637-016-0407-Y

1 reference

9 July 2018

Dimensions Publication ID

0 references

1 reference

9 July 2018

PubMed publication ID

27917453

1 reference

9 July 2018