The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model (Q33383707)

26 July 2017

title

The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model (English)

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acute megakaryoblastic leukemia

26 July 2017

1 reference

1 reference

Yana Pikman

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Dominique Baudry-Bluteau

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Thomas Mercher

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Nicolas Cagnard

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Jean-Pierre Bourquin

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William Vainchenker

1 reference

26 July 2017

Glen D Raffel

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26 July 2017

Sandra A Moore

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26 July 2017

Melanie G Cornejo

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26 July 2017

Jonathan L Jesneck

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26 July 2017

Dana Cullen

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26 July 2017

Ifor R Williams

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26 July 2017

Koichi Akashi

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26 July 2017

Hirokazu Shigematsu

1 reference

26 July 2017

Marco Giovannini

1 reference

26 July 2017

Ross L Levine

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26 July 2017

Benjamin H Lee

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26 July 2017

Olivier A Bernard

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26 July 2017

D Gary Gilliland

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26 July 2017

language of work or name

English

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publication date

16 March 2009

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Journal of Clinical Investigation

26 July 2017

published in

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26 July 2017

volume

119

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26 July 2017

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26 July 2017

page(s)

852-864

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Activating mutations in human acute megakaryoblastic leukemia.

26 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

OTT-MAL is a deregulated activator of serum response factor-dependent gene expression

28 July 2018

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Notch directly regulates Gata3 expression during T helper 2 cell differentiation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Ott1(Rbm15) has pleiotropic roles in hematopoietic development

28 July 2018

1 reference

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Rbm15 modulates Notch-induced transcriptional activation and affects myeloid differentiation

28 July 2018

1 reference

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The multifaceted role of Notch in cancer

28 July 2018

1 reference

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Notch signalling: a simple pathway becomes complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Molecular mechanisms of megakaryopoiesis

28 July 2018

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Megakaryocyte development and platelet production.

28 July 2018

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Activating alleles of JAK3 in acute megakaryoblastic leukemia

28 July 2018

1 reference

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Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes

28 July 2018

1 reference

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Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling.

28 July 2018

1 reference

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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

28 July 2018

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Hematopoietic stem cell fate is established by the Notch-Runx pathway

28 July 2018

1 reference

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JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

28 July 2018

1 reference

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Thrombopoietin signalling in physiology and disease

28 July 2018

1 reference

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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Bioconductor: open software development for computational biology and bioinformatics

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Viral interactions with the Notch pathway

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Biology, clinical, and hematologic features of acute megakaryoblastic leukemia in children

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Actin dynamics control SRF activity by regulation of its coactivator MAL

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Transient leukaemia--a benign form of leukaemia in newborn infants with trisomy 21.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Characterization of mouse clonogenic megakaryocyte progenitors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Recurrence of OTT-MAL fusion in t(1;22) of infant AML-M7.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Thrombopoietin-mediated sustained activation of extracellular signal-regulated kinase in UT7-Mpl cells requires both Ras-Raf-1- and Rap1-B-Raf-dependent pathways

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Existence of a differentiation blockage at the stage of a megakaryocyte precursor in the thrombocytopenia and absent radii (TAR) syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Thrombopoietin-induced activation of the mitogen-activated protein kinase (MAPK) pathway in normal megakaryocytes: role in endomitosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

The translocation t(1;22)(p13;q13) is a nonrandom marker specifically associated with acute megakaryocytic leukemia in young children

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Notch signaling specifies megakaryocyte development from hematopoietic stem cells.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Serum-induced phosphorylation of the serum response factor coactivator MKL1 by the extracellular signal-regulated kinase 1/2 pathway inhibits its nuclear localization

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Imaging hematopoietic precursor division in real time

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Multiple functions of Notch signaling in self-renewing organs and cancer.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Different expression of CD41 on human lymphoid and myeloid progenitors from adults and neonates

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662544

Identification of Notch target genes in uncommitted T-cell progenitors: No direct induction of a T-cell specific gene program

31 October 2018

1 reference

12 December 2020

Biology and outcome of childhood acute megakaryoblastic leukemia: a single institution's experience

1 reference

12 December 2020

Cytogenetic profile of childhood and adult megakaryoblastic leukemia (M7): a study of the Groupe Français de Cytogénétique Hématologique (GFCH)

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12 December 2020

Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance

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12 December 2020

Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1

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12 December 2020

Distinct effects of the soluble versus membrane-bound forms of the notch ligand delta-4 on human CD34+CD38low cell expansion and differentiation

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12 December 2020

Identifiers

DOI

10.1172/JCI35901

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26 July 2017

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26 July 2017

1 reference