Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7. (Q33341310)

25 July 2017

title

Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7. (English)

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25 July 2017

Hengming Ke

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25 July 2017

Huanchen Wang

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25 July 2017

Yudong Liu

series ordinal

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25 July 2017

Yuxiang Chen

series ordinal

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25 July 2017

Howard Robinson

series ordinal

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25 July 2017

language of work or name

English

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publication date

1 July 2005

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Journal of Biological Chemistry

25 July 2017

published in

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25 July 2017

volume

280

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25 July 2017

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25 July 2017

page(s)

30949-30955

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Molecular diversity of cyclic AMP signalling

25 July 2017

cites work

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PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP.

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Phosphodiesterase 7A-deficient mice have functional T cells.

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Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart

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Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase

21 January 2018

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Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase

21 January 2018

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Refolding and purification of recombinant human PDE7A expressed in Escherichia coli as inclusion bodies

21 January 2018

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Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity

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21 January 2018

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21 January 2018

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Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules

21 January 2018

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The Crystal Structure of AMP-Bound PDE4 Suggests a Mechanism for Phosphodiesterase Catalysis,

21 January 2018

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Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity

21 January 2018

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Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding

21 January 2018

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A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases

21 January 2018

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Structural basis for the activity of drugs that inhibit phosphodiesterases

21 January 2018

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Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M504398200

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25 July 2017

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