The Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells (Q33294960)

25 July 2017

title

The Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells (English)

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25 July 2017

Alan Yueh-Luen Lee

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Enbo Liu

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25 July 2017

Xiaohua Wu

series ordinal

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25 July 2017

language of work or name

English

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publication date

22 August 2007

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Journal of Biological Chemistry

25 July 2017

published in

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25 July 2017

volume

282

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25 July 2017

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25 July 2017

page(s)

32243-32255

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DNA replication in eukaryotic cells

25 July 2017

cites work

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Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

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A p53-dependent checkpoint pathway prevents rereplication

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Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint

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Loss of Geminin induces rereplication in the presence of functional p53

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Oncogenic potential of the DNA replication licensing protein CDT1

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

21 January 2018

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Disruption of mechanisms that prevent rereplication triggers a DNA damage response

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Loss of rereplication control in Saccharomyces cerevisiae results in extensive DNA damage

21 January 2018

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Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus

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An ATR- and BRCA1-mediated Fanconi anemia pathway is required for activating the G2/M checkpoint and DNA damage repair upon rereplication

21 January 2018

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The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

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Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

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Requirement of the MRN complex for ATM activation by DNA damage

21 January 2018

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ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

21 January 2018

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ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

21 January 2018

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Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

21 January 2018

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

21 January 2018

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ATM-dependent phosphorylation of nibrin in response to radiation exposure

21 January 2018

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The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A.

21 January 2018

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Rapid activation of ATR by ionizing radiation requires ATM and Mre11

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The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment.

21 January 2018

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A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

21 January 2018

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Nbs1 is required for ATR-dependent phosphorylation events

21 January 2018

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ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705486200

Rad50 depletion impacts upon ATR-dependent DNA damage responses

21 January 2018

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SV40 T antigen interacts with Nbs1 to disrupt DNA replication control.

21 January 2018

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Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

21 January 2018

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Telomerase maintains telomere structure in normal human cells.

21 January 2018

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ATR Regulates Fragile Site Stability

21 January 2018

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A simplified system for generating recombinant adenoviruses

21 January 2018

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21 January 2018

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Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks

21 January 2018

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Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage

21 January 2018

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A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

21 January 2018

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ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

21 January 2018

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

21 January 2018

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H2AX: the histone guardian of the genome

21 January 2018

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Functional analysis of FHA and BRCT domains of NBS1 in chromatin association and DNA damage responses

21 January 2018

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Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation

21 January 2018

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REPLICATION PROTEIN A: A Heterotrimeric, Single-Stranded DNA-Binding Protein Required for Eukaryotic DNA Metabolism

21 January 2018

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Identical short peptide sequences in unrelated proteins can have different conformations: a testing ground for theories of immune recognition.

21 January 2018

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705486200

Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705486200

Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705486200

Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705486200

Individuals' leukocyte DNA double-strand break repair as an indicator of radiosurgery responses for cerebral arteriovenous malformations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705486200

Cyclin and cyclin-dependent kinase substrate requirements for preventing rereplication reveal the need for concomitant activation and inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705486200

The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705486200

Visualization of altered replication dynamics after DNA damage in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705486200

Deregulated replication licensing causes DNA fragmentation consistent with head-to-tail fork collision.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705486200

The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705486200

Replication protein A and the Mre11.Rad50.Nbs1 complex co-localize and interact at sites of stalled replication forks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705486200

A dynamic model for replication protein A (RPA) function in DNA processing pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705486200

Chromosomal translocations in human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705486200

Double-strand breaks and translocations in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705486200

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705486200

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705486200

CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705486200

Interaction of FANCD2 and NBS1 in the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705486200

Unbalanced expression of licensing DNA replication factors occurs in a subset of mantle cell lymphomas with genomic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705486200

21 January 2018

Identifiers

DOI

10.1074/JBC.M705486200

1 reference

25 July 2017

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