The key role of apolipoprotein E in atherosclerosis (Q33213990)

https://api.crossref.org/works/10.1007%2FS00109-004-0631-3

Comparison of the stabilities and unfolding pathways of human apolipoprotein E isoforms by differential scanning calorimetry and circular dichroism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-004-0631-3

Meta-analysis: apolipoprotein E genotypes and risk for coronary heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-004-0631-3

Retroviral gene therapy in ApoE-deficient mice: ApoE expression in the artery wall reduces early foam cell lesion formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-004-0631-3

Low levels of extrahepatic nonmacrophage ApoE inhibit atherosclerosis without correcting hypercholesterolemia in ApoE-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-004-0631-3

Apolipoprotein E inhibition of vascular smooth muscle cell proliferation but not the inhibition of migration is mediated through activation of inducible nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-004-0631-3

Apolipoprotein E Alleles and Risk of Coronary Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-004-0631-3

The effectiveness of hydroxy-methylglutaryl coenzyme A reductase inhibitors (statins) in the elderly is not influenced by apolipoprotein E genotype

21 January 2018

1 reference

12 December 2020

Apolipoprotein E polymorphism affects carotid artery atherosclerosis in smoking hypertensive men

1 reference

12 December 2020

Detection of a new apolipoprotein-E mutation in type III hyperlipidemia using deoxyribonucleic acid restriction isotyping

1 reference

12 December 2020

Apolipoprotein E inhibition of proliferation of mitogen-activated T lymphocytes: production of interleukin 2 with reduced biological activity.

1 reference

12 December 2020

Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription.

1 reference

12 December 2020

The cell biology and physiologic relevance of ApoE recycling

1 reference

12 December 2020

Apolipoprotein E4 and coronary heart disease in middle-aged men who smoke: a prospective study

1 reference

12 December 2020

Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice

1 reference

12 December 2020

Synergistic effect between apolipoprotein E and angiotensinogen gene polymorphisms in the risk for early myocardial infarction

1 reference

12 December 2020

A newly identified polymorphism in the apolipoprotein E enhancer gene region is associated with Alzheimer's disease and strongly with the epsilon 4 allele

1 reference

12 December 2020

Comparison of Lipid-Binding and Lecithin:Cholesterol Acyltransferase Activation of the Amino- and Carboxyl-Terminal Domains of Human Apolipoprotein E3

1 reference

12 December 2020

Apolipoprotein E enhances lipid exchange between lipoproteins mediated by cholesteryl ester transfer protein

1 reference

12 December 2020

Apolipoprotein E inhibits platelet aggregation through the L-arginine:nitric oxide pathway. Implications for vascular disease

1 reference

12 December 2020

Genetic variation atapolipoprotein E locus in Ethiopia: an E5 variant corresponds to two different mutant alleles: E*5 (Glu212Lys) and E*5 (Gln204Lys; Cys112Arg).

1 reference

12 December 2020

Increased serum remnant lipoproteins in patients with apolipoprotein E7 (apo E Suita)

1 reference

12 December 2020

Tumor necrosis factor-alpha modulates monocyte/macrophage apoprotein E gene expression

1 reference

12 December 2020

A quantitative analysis of apolipoprotein binding to SR-BI: multiple binding sites for lipid-free and lipid-associated apolipoproteins

1 reference

12 December 2020

Normalization of receptor binding of apolipoprotein E2. Evidence for modulation of the binding site conformation

1 reference

12 December 2020

Degradation of macrophage ApoE in a nonlysosomal compartment. Regulation by sterols

1 reference

12 December 2020

Obesity and alcohol modulate the effect of apolipoprotein E polymorphism on lipids and insulin

1 reference

12 December 2020

Expression of the apolipoprotein E gene in the skin is controlled by a unique downstream enhancer

1 reference

12 December 2020

Regulation of apolipoprotein E secretion by high density lipoprotein 3 in mouse macrophages

1 reference

12 December 2020

Macrophage free cholesterol content regulates apolipoprotein E synthesis

1 reference

12 December 2020

Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E

1 reference

12 December 2020

Lipoprotein lipase reduces secretion of apolipoprotein E from macrophages

1 reference

12 December 2020

Apolipoprotein E (apoE) isoforms differentially induce nitric oxide production in endothelial cells

1 reference

12 December 2020

Apoprotein E suppresses phytohemagglutinin-activated phospholipid turnover in peripheral blood mononuclear cells

1 reference

12 December 2020

Characterization of a new apolipoprotein E5 variant detected in two French-Canadian subjects

1 reference

12 December 2020

Exogenous glucocorticoids increase macrophage secretion of apo E by cholesterol-independent pathways

1 reference

12 December 2020

Two Hepatic Enhancers, HCR.1 and HCR.2, Coordinate the Liver Expression of the Entire Human Apolipoprotein E/C-I/C-IV/C-II Gene Cluster

1 reference

12 December 2020

Apolipoprotein E in macrophages and hepatocytes is eegraded via the proteasomal pathway

1 reference

12 December 2020

Early kinetics of human macrophage apolipoprotein E synthesis and incorporation of carbohydrate precursors

1 reference

12 December 2020

Apolipoprotein E receptors: linking brain development and Alzheimer's disease

1 reference

12 December 2020

Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus

1 reference

12 December 2020

Cytokine regulation of macrophage apo E secretion: opposing effects of GM-CSF and TGF-beta

1 reference

12 December 2020

Apolipoprotein E participates in the regulation of very low density lipoprotein-triglyceride secretion by the liver

1 reference

12 December 2020

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

1 reference

12 December 2020

An apolipoprotein E synthetic peptide targets to lipoproteins in plasma and mediates both cellular lipoprotein interactions in vitro and acute clearance of cholesterol-rich lipoproteins in vivo

1 reference

12 December 2020

Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E

1 reference

12 December 2020

Two distal downstream enhancers direct expression of the human apolipoprotein E gene to astrocytes in the brain.

1 reference

12 December 2020

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

1 reference

12 December 2020

Effect of apoE genotype on the hypolipidaemic response to pravastatin in an outpatient setting.

1 reference

12 December 2020

Role of HDL apolipoprotein E in cellular cholesterol efflux: studies in apo E knockout transgenic mice

1 reference

12 December 2020

Dietary fat clearance in type V hyperlipoproteinaemia secondary to a rare variant of human apolipoprotein E: the apolipoprotein E3 (Arg 136-->Ser)

1 reference

12 December 2020

Hormonal regulation of human apolipoprotein E gene expression in HepG2 cells

1 reference

12 December 2020

Intracellular processing of endocytosed triglyceride-rich lipoproteins comprises both recycling and degradation

1 reference

12 December 2020

Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia

1 reference

12 December 2020

Two apolipoprotein E5 variants illustrate the importance of the position of additional positive charge on receptor-binding activity

1 reference

12 December 2020

Familial apolipoprotein E deficiency

1 reference

12 December 2020

Rapid regression of atherosclerosis induced by liver-directed gene transfer of ApoE in ApoE-deficient mice

1 reference

12 December 2020

Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides

1 reference

12 December 2020

Complete atherosclerosis regression after human ApoE gene transfer in ApoE-deficient/nude mice

1 reference

12 December 2020

ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum.

1 reference

12 December 2020

Bone marrow transplantation in apolipoprotein E-deficient mice. Effect of ApoE gene dosage on serum lipid concentrations, (beta)VLDL catabolism, and atherosclerosis

1 reference

12 December 2020

Apolipoprotein E: structure-function relationships

1 reference

12 December 2020

Identification and characterization of a novel apolipoprotein E variant, apolipoprotein E3' (Arg136-->His): association with mild dyslipidemia and double pre-beta very low density lipoproteins

1 reference

12 December 2020

Effect of atorvastatin on ApoE and ApoC-I synthesis and secretion by THP-1 macrophages

1 reference

12 December 2020

Effect of apolipoprotein E and A-IV phenotypes on the low density lipoprotein response to HMG CoA reductase inhibitor therapy

1 reference

12 December 2020

Abnormal in vivo metabolism of apolipoprotein E4 in humans

1 reference

12 December 2020

Expression of ApoE gene in Chinese hamster cells with a reversible defect in O-glycosylation. Glycosylation is not required for apoE secretion

1 reference

12 December 2020

Abundant expression of apoprotein E by macrophages in human and rabbit atherosclerotic lesions.

1 reference

12 December 2020

Apolipoprotein E restricts interleukin-dependent T lymphocyte proliferation at the G1A/G1B boundary.

1 reference

12 December 2020

Elimination of macrophage-specific apolipoprotein E reduces diet-induced atherosclerosis in C57BL/6J male mice

1 reference

12 December 2020

Recycling of apoprotein E is associated with cholesterol efflux and high density lipoprotein internalization.

1 reference

12 December 2020

Phenotype-dependent differences in apolipoprotein E metabolism and in cholesterol homeostasis in human monocyte-derived macrophages

1 reference

12 December 2020

Characterization of five new mutants in the carboxyl-terminal domain of human apolipoprotein E: no cosegregation with severe hyperlipidemia.

1 reference

12 December 2020

Trans-repressor BEF-1 phosphorylation. A potential control mechanism for human ApoE gene regulation

1 reference

12 December 2020

Glycosylation of human apolipoprotein E. The carbohydrate attachment site is threonine 194.

1 reference

12 December 2020

Impaired secretion of very low density lipoprotein-triglycerides by apolipoprotein E- deficient mouse hepatocytes

1 reference

12 December 2020

New insights into the heparan sulfate proteoglycan-binding activity of apolipoprotein E.

1 reference

12 December 2020

Polymorphisms of the apolipoprotein E gene and severity of coronary artery disease defined by angiography

1 reference

12 December 2020

Identification of a peroxisome-proliferator-activated-receptor response element in the apolipoprotein E gene control region

1 reference

12 December 2020

The influence of the apolipoprotein E gene promoter (-219G/ T) polymorphism on postprandial lipoprotein metabolism in young normolipemic males

1 reference

12 December 2020

The apolipoprotein epsilon4 allele determines prognosis and the effect on prognosis of simvastatin in survivors of myocardial infarction : a substudy of the Scandinavian simvastatin survival study

1 reference

12 December 2020

Duplicated downstream enhancers control expression of the human apolipoprotein E gene in macrophages and adipose tissue

1 reference

12 December 2020

Cyclic AMP induces apolipoprotein E binding activity and promotes cholesterol efflux from a macrophage cell line to apolipoprotein acceptors

1 reference

12 December 2020

The recycling of apolipoprotein E and its amino-terminal 22 kDa fragment: evidence for multiple redundant pathways

1 reference

12 December 2020

Molecular interactions between apoE and ABCA1: impact on apoE lipidation

1 reference

12 December 2020

Association between the PPARA L162V polymorphism and plasma lipid levels: the Framingham Offspring Study

1 reference

12 December 2020

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

1 reference

12 December 2020

Synthesis, intracellular processing, and signal peptide of human apolipoprotein E

1 reference

12 December 2020

Endogenous apoE expression modulates HDL3 binding to macrophages.

1 reference

12 December 2020

Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins.

1 reference

12 December 2020

The modulation of apolipoprotein E gene expression by 3,3'-5-triiodothyronine in HepG2 cells occurs at transcriptional and post-transcriptional levels.

1 reference

12 December 2020

Cell-derived apolipoprotein E (ApoE) particles inhibit vascular cell adhesion molecule-1 (VCAM-1) expression in human endothelial cells

1 reference

12 December 2020

Transcriptional regulation of apolipoprotein E expression by cyclic AMP

1 reference

12 December 2020

Relation of apolipoprotein E phenotype to myocardial infarction and mortality from coronary artery disease

1 reference

12 December 2020

Human apolipoprotein E. Determination of the heparin binding sites of apolipoprotein E3

1 reference

12 December 2020

Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review

1 reference

12 December 2020

Allelic polymorphism -491A/T in apo E gene modulates the lipid-lowering response in combined hyperlipidemia treatment

1 reference

12 December 2020

Regulation of apolipoprotein E production in macrophages (review).

1 reference

12 December 2020

Apolipoprotein E: far more than a lipid transport protein

1 reference

12 December 2020

Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption

1 reference

12 December 2020

Role of apolipoprotein E in hepatic lipase catalyzed hydrolysis of phospholipid in high-density lipoproteins

1 reference

12 December 2020

Apolipoprotein E1 Baden (Arg(180)-->Cys). A new apolipoprotein E variant associated with hypertriglyceridemia

1 reference

12 December 2020

Heterogeneity of human plasma very low density lipoproteins. Separation of species differing in protein components

1 reference

12 December 2020

Effects of lipid interaction on the lysine microenvironments in apolipoprotein E

1 reference

12 December 2020

Genetic determinants of plasma lipid response to dietary intervention: the role of the APOA1/C3/A4 gene cluster and the APOE gene

1 reference

12 December 2020

Apolipoprotein E: a potent inhibitor of endothelial and tumor cell proliferation.

1 reference

12 December 2020

Reconstituted discoidal ApoE-phospholipid particles are ligands for the scavenger receptor BI. The amino-terminal 1-165 domain of ApoE suffices for receptor binding.

1 reference

12 December 2020

Charting the fate of the "good cholesterol": identification and characterization of the high-density lipoprotein receptor SR-BI.

1 reference

12 December 2020

Hepatic apo E expression is required for remnant lipoprotein clearance in the absence of the low density lipoprotein receptor

1 reference

12 December 2020

Evaluation of the role of Ap1-like proteins in the enhanced apolipoprotein E gene transcription accompanying phorbol ester induced macrophage differentiation

1 reference

12 December 2020

Heterozygosity for apolipoprotein E-4Philadelphia(Glu13----Lys, Arg145----Cys) is associated with incomplete dominance of type III hyperlipoproteinemia

1 reference

12 December 2020

The correlation of ATP-binding cassette 1 mRNA levels with cholesterol efflux from various cell lines

1 reference

12 December 2020

ATP binding cassette transporter ABCA1 modulates the secretion of apolipoprotein E from human monocyte-derived macrophages.

1 reference

12 December 2020

Expression of heterologous human apolipoprotein E by J774 macrophages enhances cholesterol efflux to HDL3.

1 reference

12 December 2020

Type III hyperlipoproteinemia associated with apolipoprotein E deficiency

1 reference

12 December 2020

Transcriptional and post-transcriptional control of apolipoprotein E gene expression in differentiating human monocytes

1 reference

12 December 2020

ApoE genotype accounts for the vast majority of AD risk and AD pathology

1 reference

12 December 2020

Apolipoprotein E receptor binding versus heparan sulfate proteoglycan binding in its regulation of smooth muscle cell migration and proliferation

1 reference

12 December 2020

Post-translational regulation of macrophage apoprotein E production

1 reference

12 December 2020

A Recycling Pathway for Resecretion of Internalized Apolipoprotein E in Liver Cells

1 reference

12 December 2020

Apolipoprotein E polymorphism and atherosclerosis

1 reference

12 December 2020

Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes.

1 reference

12 December 2020

Genetics, postprandial lipemia and obesity.

1 reference

12 December 2020

Lack of interaction of apolipoprotein E phenotype with the lipoprotein response to lovastatin or gemfibrozil in patients with primary hypercholesterolemia

1 reference

12 December 2020

Atherosclerosis — An Inflammatory Disease

1 reference

12 December 2020

Oleic acid modulates the post-translational glycosylation of macrophage ApoE to increase its secretion

1 reference

12 December 2020

Transport and processing of endogenously synthesized ApoE on the macrophage cell surface

1 reference

12 December 2020

Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins

1 reference

12 December 2020

Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E

1 reference

12 December 2020

Identification and characterization of LRP8 (apoER2) in human blood platelets

1 reference

12 December 2020

Risk for Alzheimer's disease correlates with transcriptional activity of the APOE gene.

1 reference

12 December 2020

Differences in stability among the human apolipoprotein E isoforms determined by the amino-terminal domain

1 reference

12 December 2020

Effects of polymorphism on the lipid interaction of human apolipoprotein E.

1 reference

12 December 2020

Recycling of apolipoprotein E and lipoprotein lipase through endosomal compartments in vivo.

1 reference

12 December 2020

The role of apolipoprotein E genetic variants in lipoprotein disorders

1 reference

12 December 2020

Effects of a frequent apolipoprotein E isoform, ApoE4Freiburg (Leu28-->Pro), on lipoproteins and the prevalence of coronary artery disease in whites

1 reference

12 December 2020

Apolipoprotein gene and its interaction with the environmentally driven risk factors: molecular, genetic and epidemiological studies of Alzheimer's disease

1 reference

12 December 2020

Apolipoprotein E secretion by macrophages: its potential physiological functions.

1 reference

12 December 2020

Interferon-gamma inhibits macrophage apolipoprotein E production by posttranslational mechanisms

1 reference

12 December 2020

Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets

1 reference

12 December 2020

Independent association of an APOE gene promoter polymorphism with increased risk of myocardial infarction and decreased APOE plasma concentrations--the ECTIM Study

1 reference

12 December 2020

Inter-molecular coiled-coil formation in human apolipoprotein E C-terminal domain

1 reference

12 December 2020

Two Italian kindreds carrying the Arg136-->Ser mutation of the Apo E gene: development of premature and severe atherosclerosis in the presence of epsilon 2 as second allele.

1 reference

12 December 2020

Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E.

1 reference

12 December 2020

Apolipoprotein E gene expression in various tissues of mouse and regulation by estrogen.

1 reference

12 December 2020

Gene therapy of apolipoprotein E-deficient mice using a novel macrophage-specific retroviral vector

1 reference

12 December 2020

Recycling of apolipoprotein E in mouse liver

1 reference

12 December 2020

An ecological study of association between coronary heart disease mortality rates in men and the relative frequencies of common allelic variations in the gene coding for apolipoprotein E.

1 reference

12 December 2020

Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia

1 reference

12 December 2020

Apolipoprotein E2 (Arg-136-->Cys), a variant of apolipoprotein E associated with late-onset dominance of type III hyperlipoproteinaemia

1 reference

12 December 2020

Effects of gender and menopausal status on the association of apolipoprotein E phenotype with plasma lipoprotein levels. Results from the Framingham Offspring Study

1 reference

12 December 2020

Site-specific mutagenesis of human apolipoprotein E. Receptor binding activity of variants with single amino acid substitutions

1 reference

12 December 2020

Lipid-bound Structure of an Apolipoprotein E-derived Peptide

1 reference

12 December 2020

Interaction with proteoglycans enhances the sterol efflux produced by endogenous expression of macrophage apoE.

1 reference

12 December 2020

Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall

1 reference

12 December 2020

Apolipoprotein E1-Hammersmith (Lys146-->Asn;Arg147-->Trp), due to a dinucleotide substitution, is associated with early manifestation of dominant type III hyperlipoproteinaemia

1 reference

12 December 2020

Testing the role of apoA-I, HDL, and cholesterol efflux in the atheroprotective action of low-level apoE expression

1 reference

12 December 2020

Mechanisms of enhanced macrophage apoE secretion by oxidized LDL

1 reference

12 December 2020

Apolipoprotein E5 (Glu212-->Lys): increased binding to cell surface proteoglycans but decreased uptake and lysosomal degradation in cultured fibroblasts

1 reference

12 December 2020

Accelerated atherosclerosis in C57Bl/6 mice transplanted with ApoE-deficient bone marrow

1 reference

12 December 2020

Quantitation of apolipoprotein E mRNA in the liver and peripheral tissues of nonhuman primates

1 reference

12 December 2020

Transcriptional activation of the lipoprotein lipase and apolipoprotein E genes accompanies differentiation in some human macrophage-like cell lines

1 reference

12 December 2020

Inhibition of Ca2+ accumulation in mitogen-activated lymphocytes: role of membrane-bound plasma lipoproteins

1 reference

12 December 2020

Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation

1 reference

12 December 2020

Cell surface proteoglycans modulate net synthesis and secretion of macrophage apolipoprotein E.

1 reference

12 December 2020

Characterization of an apolipoprotein E3 variant (Arg 145-->His) associated with mild hypertriglyceridemia

1 reference

12 December 2020

Apolipoprotein E binding to low density lipoprotein receptor-related protein-1 inhibits cell migration via activation of cAMP-dependent protein kinase A.

1 reference

12 December 2020

Lysosomal degradation and sorting of apolipoprotein E in macrophages.

1 reference

12 December 2020

Apolipoprotein E gene promoter (-219G/T) polymorphism is associated with premature coronary heart disease

1 reference

12 December 2020

Antimitogenic effects of HDL and APOE mediated by Cox-2-dependent IP activation

1 reference

12 December 2020

Identification of a new apolipoprotein E variant (E2 Arg142-->Leu) in type III hyperlipidemia

1 reference

12 December 2020

Human apolipoprotein E. Receptor binding activity of truncated variants with carboxyl-terminal deletions

1 reference

12 December 2020

Diminished LDL receptor and high heparin binding of apolipoprotein E2 Sendai associated with lipoprotein glomerulopathy

1 reference

12 December 2020

Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene

1 reference

12 December 2020

No APOEepsilon4 effect on coronary heart disease risk in a cohort with low smoking prevalence: the Whitehall II study

1 reference

12 December 2020

Endotoxin and GM-CSF-mediated down-regulation of macrophage apo E secretion is inhibited by a TNF-specific monoclonal antibody.

1 reference

12 December 2020

Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages

1 reference

12 December 2020

Apolipoprotein A-I stimulates secretion of apolipoprotein E by foam cell macrophages

1 reference

12 December 2020