Measuring human brain GABA in vivo: effects of GABA-transaminase inhibition with vigabatrin (Q32066867)

6 July 2017

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title

Measuring human brain GABA in vivo: effects of GABA-transaminase inhibition with vigabatrin (English)

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6 July 2017

O A Petroff

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6 July 2017

D L Rothman

series ordinal

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6 July 2017

publication date

1 February 1998

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6 July 2017

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inferred from page(s)

published in

Molecular Neurobiology

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6 July 2017

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6 July 2017

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6 July 2017

page(s)

97-121

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The effect of different vigabatrin treatment regimens on CSF biochemistry and seizure control in epileptic patients

6 July 2017

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Is the intracellular pH different from normal in the epileptic focus of patients with temporal lobe epilepsy? A 31P NMR study

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In vivo 31P nuclear magnetic resonance spectroscopy of human temporal lobe epilepsy

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1H magnetic resonance spectroscopy of extracts of human epileptic neocortex and hippocampus

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Human brain GABA levels rise after initiation of vigabatrin therapy but fail to rise further with increasing dose

21 January 2018

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Human brain GABA levels rise rapidly after initiation of vigabatrin therapy

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Long-term antiepileptic efficacy of vigabatrin in drug-refractory epilepsy in mentally retarded patients. A 5-year follow-up study.

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Cerebrospinal fluid GABA and seizure control with vigabatrin

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Clinical pharmacology of vigabatrin

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Value of the electroencephalogram in adult patients with untreated idiopathic first seizures

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Low cerebrospinal fluid -aminobutyric acid content in seizure patients

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The rate of turnover of cortical GABA from [1-13C]glucose is reduced in rats treated with the GABA-transaminase inhibitor vigabatrin (gamma-vinyl GABA).

21 January 2018

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12 December 2020

Biochemical and clinical effects of gamma-vinyl GABA in patients with epilepsy

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12 December 2020

Localized 13C NMR spectroscopy in the human brain of amino acid labeling from D-[1-13C]glucose

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12 December 2020

The level of GAD67 protein is highly sensitive to small increases in intraneuronal gamma-aminobutyric acid levels.

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12 December 2020

Regulatory properties of brain glutamate decarboxylase

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12 December 2020

Clinical applications: MRI, SPECT, and PET.

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12 December 2020

Amino acid and catecholamine markers of metabolic abnormalities in human focal epilepsy

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12 December 2020

Excitatory amino acids are elevated in human epileptic cerebral cortex

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12 December 2020

A double-blind, placebo-controlled study of vigabatrin three g/day in patients with uncontrolled complex partial seizures. Vigabatrin Protocol 024 Investigative Cohort

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gamma-Vinyl GABA (4-amino-hex-5-enoic acid), a new selective irreversible inhibitor of GABA-T: effects on brain GABA metabolism in mice

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The structural and functional heterogeneity of glutamic acid decarboxylase: A review

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Amino acids in the neuronal microenvironment of focal human epileptic lesions

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12 December 2020

Uptake of gamma-aminobutyric acid by brain tissue preparations: a reevaluation

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12 December 2020

Neuronal and glial systems for gamma-aminobutyric acid metabolism

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12 December 2020

Immunocytochemical evidence that vigabatrin in rats causes GABA accumulation in glial cells of the retina

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12 December 2020

GABA induces down-regulation of the benzodiazepine-GABA receptor complex in the rat cultured neurons

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12 December 2020

The potential for increasing seizure frequency, relapse, and appearance of new seizure types with vigabatrin

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12 December 2020

Pharmacokinetic effects of vigabatrin on cerebrospinal fluid amino acids in humans

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12 December 2020

Identification of seizure-mediating brain structures with the deoxyglucose method: studies of human epilepsy with positron emission tomography, and animal seizure models with contact autoradiography

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12 December 2020

One to three day dose intervals during subchronic treatment of epileptic gerbils with gamma-vinyl GABA: anticonvulsant efficacy and alterations in regional brain GABA levels

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12 December 2020

Failure of GABAergic inhibition: a key to local and global seizures

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12 December 2020

Stereoselective uptake of the GABA-transaminase inhibitors gamma-vinyl GABA and gamma-acetylenic GABA into neurons and astrocytes

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12 December 2020

Magnetic resonance spectroscopy in temporal lobe epilepsy

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12 December 2020

Regulation of gamma-aminobutyric acid synthesis in the brain

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12 December 2020

Neuron loss localizes human temporal lobe epilepsy by in vivo proton magnetic resonance spectroscopic imaging

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12 December 2020

Measurement of GABA following GABA-transaminase inhibition by gabaculine: a 1H and 31P NMR spectroscopic study of rat brain in vivo

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12 December 2020

Regulation of the GABAA receptor/ion channel complex by intracellular GABA levels

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12 December 2020

Effect of long-term vigabatrin therapy on selected neurotransmitter concentrations in cerebrospinal fluid

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12 December 2020

Clinical administration of new antiepileptic drugs: an overview of safety and efficacy

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12 December 2020

Chronic GABA treatment downregulates the GABAA receptor alpha 2 and alpha 3 subunit mRNAS as well as polypeptide expression in primary cultured cerebral cortical neurons

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12 December 2020

Symbiosis between in vivo and in vitro NMR spectroscopy: the creatine, N-acetylaspartate, glutamate, and GABA content of the epileptic human brain

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12 December 2020

Amino acid levels in the cerebrospinal fluid of newly diagnosed epileptic patients: effect of vigabatrin and carbamazepine monotherapies

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12 December 2020

Glutamate and glutamine metabolism and compartmentation in astrocytes.

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12 December 2020

The relationship between GABA concentrations in brain and cerebrospinal fluid

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12 December 2020

Cerebral metabolic compartmentation as revealed by nuclear magnetic resonance analysis of D-[1-13C]glucose metabolism

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12 December 2020

Glutamine and Glucose as Precursors of Transmitter Amino Acids: Ex Vivo Studies

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12 December 2020

The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy

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12 December 2020

Homonuclear 1H double-resonance difference spectroscopy of the rat brain in vivo

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12 December 2020

Electrophysiology of GABA-mediated synaptic transmission and possible roles in epilepsy

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12 December 2020

Metabolism and transport of amino acids studied by immunocytochemistry

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12 December 2020

Assignment of resonance in the 1H spectrum of rat brain by two-dimensional shift correlated and J-resolved NMR spectroscopy

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12 December 2020

Gabapentin potentiates the conductance increase induced by nipecotic acid in CA1 pyramidal neurons in vitro

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12 December 2020

Anticonvulsant and proconvulsant effects of inhibitors of GABA degradation in the amygdala-kindling model

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12 December 2020

Alterations of GABA-mediated synaptic transmission in human epilepsy

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12 December 2020

Synthesis and release of neuroactive substances by glial cells

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12 December 2020

Emerging perspectives on the mechanism of action of gabapentin

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12 December 2020

Expression of excitatory amino acid receptors by cerebellar cells of the type-2 astrocyte cell lineage

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12 December 2020

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12 December 2020

Long-term outcome after epilepsy surgery

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12 December 2020

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12 December 2020

Uptake of gamma-aminobutyric acid by a synaptic vesicle fraction isolated from rat brain

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12 December 2020

Normalization of contralateral metabolic function following temporal lobectomy demonstrated by 1H magnetic resonance spectroscopic imaging

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12 December 2020

Analysis of [1-13C]D-glucose metabolism in cultured astrocytes and neurons using nuclear magnetic resonance spectroscopy

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12 December 2020

Effect of long-term vigabatrin therapy on GABA and other amino acid concentrations in the central nervous system--a case study

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12 December 2020

Direct demonstration by [13C]NMR spectroscopy that glutamine from astrocytes is a precursor for GABA synthesis in neurons

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12 December 2020

Phosphorus magnetic resonance spectroscopic imaging in patients with frontal lobe epilepsy.

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12 December 2020

Specificity of vigabatrin for the GABAergic system in human epilepsy

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12 December 2020

Localized 1H NMR spectra of glutamate in the human brain

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12 December 2020

Pathophysiology of status epilepticus.

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12 December 2020

Characterization of macromolecule resonances in the 1H NMR spectrum of rat brain

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12 December 2020

Increased gamma-aminobutyric acid (GABA), homocarnosine and beta-alanine in cerebrospinal fluid of patients treated with gamma-vinyl GABA (4-amino-hex-5-enoic acid)

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12 December 2020

Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation?

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12 December 2020

N-acetylaspartate and epilepsy

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12 December 2020

Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors

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12 December 2020

Regulatory role of astrocytes for neuronal biosynthesis and homeostasis of glutamate and GABA

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12 December 2020

Proton nuclear magnetic resonance spectroscopic imaging of human temporal lobe epilepsy at 4.1 T

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12 December 2020

Temporal lobe epilepsy: correlation of proton magnetic resonance spectroscopy and 18F-fluorodeoxyglucose positron emission tomography

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12 December 2020

Effects of single doses of vigabatrin on CSF concentrations of GABA, homocarnosine, homovanillic acid and 5-hydroxyindoleacetic acid in patients with complex partial epilepsy

1 reference

12 December 2020

Low brain GABA level is associated with poor seizure control

1 reference

12 December 2020

Analysis of macromolecule resonances in 1H NMR spectra of human brain

1 reference

12 December 2020

Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo

1 reference

12 December 2020

GABA release triggered by the activation of neuron-like non-NMDA receptors in cultured type 2 astrocytes is carrier-mediated

1 reference

12 December 2020

Hippocampal GABA transporter function in temporal-lobe epilepsy

1 reference

12 December 2020

gamma-Aminobutyric acid in brain: its formation from glutamic acid.

1 reference

12 December 2020

Pharmacokinetics of new antiepileptic drugs

1 reference

12 December 2020

Postmortem changes of amino compounds in human and rat brain

1 reference

12 December 2020

High-field proton magnetic resonance spectroscopy of human cerebrum obtained during surgery for epilepsy

1 reference

12 December 2020

Vigabatrin modulates benzodiazepine receptor activity in vivo: a positron emission tomography study in baboon

1 reference

12 December 2020

Lateralization of temporal lobe epilepsy based on regional metabolic abnormalities in proton magnetic resonance spectroscopic images

1 reference

12 December 2020

Gabapentin increases GABA-induced depolarization in rat neonatal optic nerve

1 reference

12 December 2020

Utilization of glutamine and of TCA cycle constituents as precursors for transmitter glutamate and GABA.

1 reference

12 December 2020

Proton magnetic resonance spectroscopic imaging for discrimination of absence and complex partial seizures

1 reference

12 December 2020

Human brain gamma-aminobutyric acid levels and seizure control following initiation of vigabatrin therapy

1 reference

12 December 2020

Initial observations on effect of vigabatrin on in vivo 1H spectroscopic measurements of gamma-aminobutyric acid, glutamate, and glutamine in human brain

1 reference

12 December 2020

Effect of Amygdaloid Kindling on the Content and Release of Amino Acids from the Amygdaloid Complex: In Vivo and In Vitro Studies

1 reference

12 December 2020

Clinical relevance of measuring GABA concentrations in cerebrospinal fluid

1 reference

12 December 2020

Inhibitory and excitatory amino acids in CSF of patients suffering from complex partial seizures during chronic treatment with gamma-vinyl GABA (vigabatrin)

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF02740605

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Dimensions Publication ID

6 July 2017

1018783252

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