Genetically modified pig models for neurodegenerative disorders (Q31002975)

28 June 2017

title

Genetically modified pig models for neurodegenerative disorders (English)

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28 June 2017

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26446984%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Ida E Holm

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26446984%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Aage Kristian Olsen Alstrup

series ordinal

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4 June 2020

publication date

8 October 2015

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28 June 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26446984%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

volume

238

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4 June 2020

issue

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4 June 2020

page(s)

267-287

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26446984%20AND%20SRC:MED&resulttype=core&format=json

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4 June 2020

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Somatostatin- and neuropeptide Y-like immunoreactivity in the dentate area, hippocampus, and subiculum of the domestic pig

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21 January 2018

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The anatomy of the Göttingen minipig hypothalamus

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Clinical features of Alzheimer's disease

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Trafficking and proteolytic processing of APP

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PiB Fails to Map Amyloid Deposits in Cerebral Cortex of Aged Dogs with Canine Cognitive Dysfunction

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Three repeat isoforms of tau inhibit assembly of four repeat tau filaments

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Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms

21 January 2018

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Determination of Odor Detection Threshold in the Gottingen Minipig

21 January 2018

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Long-term accumulation of amyloid-beta, beta-secretase, presenilin-1, and caspase-3 in damaged axons following brain trauma

21 January 2018

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Phylogenetic diversity of the expression of the microtubule-associated protein tau: implications for neurodegenerative disorders

21 January 2018

1 reference

Hemizygous minipigs produced by random gene insertion and handmade cloning express the Alzheimer's disease-causing dominant mutation APPsw

21 January 2018

1 reference

Object recognition as a measure of memory in 1-2 years old transgenic minipigs carrying the APPsw mutation for Alzheimer's disease

21 January 2018

1 reference

Generation of minipigs with targeted transgene insertion by recombinase-mediated cassette exchange (RMCE) and somatic cell nuclear transfer (SCNT).

21 January 2018

1 reference

Juvenile onset Huntington's disease--clinical and research perspectives.

21 January 2018

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Huntington's disease. Pathogenesis and management

21 January 2018

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HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia

21 January 2018

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Huntington's disease in Chinese: a hypothesis of its origin

21 January 2018

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Analysis of triplet repeats in the huntingtin gene in Japanese families affected with Huntington's disease

21 January 2018

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A polymorphic DNA marker genetically linked to Huntington's disease

21 January 2018

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Genetics and Neuropathology of Huntington's Disease

21 January 2018

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Juvenile Huntington's disease: does a dosage-effect pathogenic mechanism differ from the classical adult disease?

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Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells

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Huntingtin aggregation and toxicity in Huntington's disease

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Multiple Aspects of Gene Dysregulation in Huntington's Disease

21 January 2018

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Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis

21 January 2018

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Rodent genetic models of Huntington disease

21 January 2018

1 reference

Inactivation of the mouse Huntington's disease gene homolog Hdh

21 January 2018

1 reference

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

21 January 2018

1 reference

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

21 January 2018

1 reference

Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice

21 January 2018

1 reference

Towards a transgenic model of Huntington's disease in a non-human primate

21 January 2018

1 reference

An ovine transgenic Huntington's disease model

21 January 2018

1 reference

Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs

21 January 2018

1 reference

Production of transgenic miniature pigs by pronuclear microinjection

21 January 2018

1 reference

Pig transgenesis by Sleeping Beauty DNA transposition

21 January 2018

1 reference

Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set.

21 January 2018

1 reference

Comparison of gene expression and genome-wide DNA methylation profiling between phenotypically normal cloned pigs and conventionally bred controls

21 January 2018

1 reference

Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

21 January 2018

1 reference

Replicative fidelity of lentiviral vectors produced by transient transfection

21 January 2018

1 reference

Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity

21 January 2018

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Parkinson's disease: mechanisms and models

21 January 2018

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Genetics of Parkinson's disease

21 January 2018

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The association between infectious burden and Parkinson's disease: A case-control study.

21 January 2018

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Traumatic brain injury in later life increases risk for Parkinson disease

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Environmental risk factors in Parkinson's disease

21 January 2018

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A guide to neurotoxic animal models of Parkinson's disease

21 January 2018

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Tyrosine hydroxylase and acetylcholinesterase in the domestic pig mesencephalon: an immunocytochemical and histochemical study

21 January 2018

1 reference

MPTP-induced Parkinsonism in minipigs: A behavioral, biochemical, and histological study

21 January 2018

1 reference

Proposed Motor Scoring System in a Porcine Model of Parkinson's Disease induced by Chronic Subcutaneous Injection of MPTP.

21 January 2018

1 reference

Sequence conservation between porcine and human LRRK2.

21 January 2018

1 reference

Characterization of the porcine FBX07 gene: the first step towards generation of a pig model for Parkinsonian pyramidal syndrome

21 January 2018

1 reference

Splicing variants of porcine synphilin-1

21 January 2018

1 reference

Association between early-onset Parkinson's disease and mutations in the parkin gene

21 January 2018

1 reference

Mutations in DJ-1 are rare in familial Parkinson disease

21 January 2018

1 reference

Efficient bi-allelic gene knockout and site-specific knock-in mediated by TALENs in pigs

21 January 2018

1 reference

Loss of PINK1 enhances neurodegeneration in a mouse model of Parkinson's disease triggered by mitochondrial stress.

21 January 2018

1 reference

Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation

21 January 2018

1 reference

Neuropathology of amyotrophic lateral sclerosis with extra-motor system degeneration: characteristics and differences in the molecular pathology between ALS with dementia and Guamanian ALS.

21 January 2018

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Neuropathology of ALS: an overview

21 January 2018

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

21 January 2018

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Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

21 January 2018

1 reference

Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS).

21 January 2018

1 reference

Species-dependent neuropathology in transgenic SOD1 pigs

21 January 2018

1 reference

Epigenetic silencing and tissue independent expression of a novel tetracycline inducible system in double-transgenic pigs.

21 January 2018

1 reference

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

21 January 2018

1 reference

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

21 January 2018

1 reference

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis

21 January 2018

1 reference

ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects

21 January 2018

1 reference

Characterization and expression analysis in the developing embryonic brain of the porcine FET family: FUS, EWS, and TAF15.

21 January 2018

1 reference

Perspectives and diagnostic considerations in spinal muscular atrophy

21 January 2018

1 reference

Natural history in proximal spinal muscular atrophy. Clinical analysis of 445 patients and suggestions for a modification of existing classifications

21 January 2018

1 reference

Identification and characterization of a spinal muscular atrophy-determining gene

21 January 2018

1 reference

Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick?

21 January 2018

1 reference

Inverse correlation between SMN1 and SMN2 copy numbers: evidence for gene conversion from SMN2 to SMN1.

21 January 2018

1 reference

Molecular analysis of spinal muscular atrophy and modification of the phenotype by SMN2.

21 January 2018

1 reference

A positive modifier of spinal muscular atrophy in the SMN2 gene

21 January 2018

1 reference

RETRACTED ARTICLE: Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN

21 January 2018

1 reference

Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model

21 January 2018

1 reference

Correction of SMN2 Pre-mRNA splicing by antisense U7 small nuclear RNAs

21 January 2018

1 reference

Phenylbutyrate increases SMN expression in vitro: relevance for treatment of spinal muscular atrophy

21 January 2018

1 reference

Aclarubicin treatment restores SMN levels to cells derived from type I spinal muscular atrophy patients

21 January 2018

1 reference

A humanized Smn gene containing the SMN2 nucleotide alteration in exon 7 mimics SMN2 splicing and the SMA disease phenotype

21 January 2018

1 reference

Disruption of the Survival Motor Neuron (SMN) gene in pigs using ssDNA.

21 January 2018

1 reference

A large animal model of spinal muscular atrophy and correction of phenotype

21 January 2018

1 reference

In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

21 January 2018

1 reference

Ataxia telangiectasia: new neurons and ATM.

21 January 2018

1 reference

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

21 January 2018

1 reference

The appropriateness of the mouse model for ataxia-telangiectasia: neurological defects but no neurodegeneration

21 January 2018

1 reference

Characterization of the porcine ATM gene: towards the generation of a novel non-murine animal model for Ataxia-Telangiectasia.

21 January 2018

1 reference

Targeted disruption of Ataxia-telangiectasia mutated gene in miniature pigs by somatic cell nuclear transfer.

21 January 2018

1 reference

A good practice guide to the administration of substances and removal of blood, including routes and volumes

21 January 2018

1 reference

Anaesthesia for positron emission tomography scanning of animal brains

21 January 2018

1 reference

Effects of anesthesia and species on the uptake or binding of radioligands in vivo in the Göttingen minipig

21 January 2018

1 reference

Imaging dopamine release with Positron Emission Tomography (PET) and (11)C-raclopride in freely moving animals

21 January 2018

1 reference

Normalization of markers for dopamine innervation in striatum of MPTP-lesioned miniature pigs with intrastriatal grafts.

21 January 2018

1 reference

Serotonergic modulation of receptor occupancy in rats treated with L-DOPA after unilateral 6-OHDA lesioning

21 January 2018

1 reference

Statistical mapping of effects of middle cerebral artery occlusion (MCAO) on blood flow and oxygen consumption in porcine brain

21 January 2018

1 reference

MR-based statistical atlas of the Göttingen minipig brain

21 January 2018

1 reference

MRI protocol for in vivo visualization of the Göttingen minipig brain improves targeting in experimental functional neurosurgery

21 January 2018

1 reference

Olfaction and Aging: A Mini-Review

21 January 2018

1 reference

RNA-programmed genome editing in human cells

21 January 2018

1 reference

Multiplex genome engineering using CRISPR/Cas systems

21 January 2018

1 reference

One-step generation of knockout pigs by zygote injection of CRISPR/Cas system

21 January 2018

1 reference

Use of the CRISPR/Cas9 system to produce genetically engineered pigs from in vitro-derived oocytes and embryos

21 January 2018

1 reference

Derivation of induced pluripotent stem cells from pig somatic cells

21 January 2018

1 reference

Generation of pig induced pluripotent stem cells with a drug-inducible system

21 January 2018

1 reference

Generation of induced pluripotent stem cell lines from Tibetan miniature pig.

21 January 2018

1 reference

Piglets cloned from induced pluripotent stem cells

21 January 2018

1 reference

First inducible transgene expression in porcine large animal models

21 January 2018

1 reference

The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs

21 January 2018

1 reference

Production of CFTR-null and CFTR-DeltaF508 heterozygous pigs by adeno-associated virus-mediated gene targeting and somatic cell nuclear transfer

21 January 2018

1 reference

Changing metabolic signatures of amino acids and lipids during the prediabetic period in a pig model with impaired incretin function and reduced β-cell mass

21 January 2018

1 reference

Permanent neonatal diabetes in INS(C94Y) transgenic pigs.

21 January 2018

1 reference

Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function

21 January 2018

1 reference

In vivo estimation of cerebral blood flow, oxygen consumption and glucose metabolism in the pig by [15O]water injection, [15O]oxygen inhalation and dual injections of [18F]fluorodeoxyglucose.

21 January 2018

1 reference

The influx of neutral amino acids into the porcine brain during development: a positron emission tomography study

21 January 2018

1 reference

Kinetics of the uptake and distribution of the dopamine D(2,3) agonist (R)-N-[1-(11)C]n-propylnorapomorphine in brain of healthy and MPTP-treated Göttingen miniature pigs

21 January 2018

1 reference

Effect of monoamine oxidase inhibition on amphetamine-evoked changes in dopamine receptor availability in the living pig: a dual tracer PET study with [11C]harmine and [11C]raclopride

21 January 2018

1 reference

Synthesis and cerebral uptake of 1-(1-[(11)C]methyl-1H-pyrrol-2-yl)-2-phenyl-2-(1-pyrrolidinyl)ethanone, a novel tracer for positron emission tomography studies of monoamine oxidase type A.

21 January 2018

1 reference

A PET study of effects of chronic 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") on serotonin markers in Göttingen minipig brain

21 January 2018

1 reference

Imaging imidazoline-I2 binding sites in porcine brain using 11C-BU99008.

21 January 2018

1 reference

Neuroimaging of the vesicular acetylcholine transporter by a novel 4-[18F]fluoro-benzoyl derivative of 7-hydroxy-6-(4-phenyl-piperidin-1-yl)-octahydro-benzo[1,4]oxazines.

21 January 2018

1 reference

In vivo imaging of human acetylcholinesterase density in peripheral organs using 11C-donepezil: dosimetry, biodistribution, and kinetic analyses

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/PATH.4654

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26446984%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26446984%20AND%20SRC:MED&resulttype=core&format=json