SUMO modification regulates BLM and RAD51 interaction at damaged replication forks (Q30940899)

18 October 2017

SUMO modification regulates BLM and RAD51 interaction at damaged replication forks (English)

1 reference

18 October 2017

Karen J Ouyang

1 reference

18 October 2017

Leslie L Woo

1 reference

18 October 2017

Jianmei Zhu

1 reference

18 October 2017

Dezheng Huo

1 reference

18 October 2017

Michael J Matunis

1 reference

18 October 2017

Nathan A Ellis

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18 October 2017

language of work or name

English

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publication date

1 December 2009

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18 October 2017

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18 October 2017

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18 October 2017

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18 October 2017

e1000252

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Creative Commons Attribution 4.0 International

18 October 2017

start time

1 December 2009

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April 2022 Public Data File from Crossref

copyrighted

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describes a project that uses

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2779653/fullTextXML

inferred from PubMed Central ID database lookup

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DNA helicases Sgs1 and BLM promote DNA double-strand break resection

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Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends

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Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway

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Endogenous gamma-H2AX-ATM-Chk2 checkpoint activation in Bloom's syndrome helicase deficient cells is related to DNA replication arrested forks

21 June 2018

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BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges

21 June 2018

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The Slx5-Slx8 complex affects sumoylation of DNA repair proteins and negatively regulates recombination

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PCNA, the maestro of the replication fork

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RecQ promotes toxic recombination in cells lacking recombination intermediate-removal proteins

21 June 2018

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Syndrome-causing mutations of the BLM gene in persons in the Bloom's Syndrome Registry

21 June 2018

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Molecular mechanisms of sister-chromatid exchange

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Ubc9- and mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks

21 June 2018

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Control of Rad52 recombination activity by double-strand break-induced SUMO modification

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21 June 2018

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A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75.

21 June 2018

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BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates

21 June 2018

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Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage

21 June 2018

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SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase

21 June 2018

1 reference

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Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase

21 June 2018

1 reference

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Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance.

21 June 2018

1 reference

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Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

21 June 2018

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Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases

21 June 2018

1 reference

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Protein modification by SUMO

21 June 2018

1 reference

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Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest

21 June 2018

1 reference

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The Bloom's syndrome helicase suppresses crossing over during homologous recombination

21 June 2018

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Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks

21 June 2018

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Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation

21 June 2018

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DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779653

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779653

Characterization of homologous recombination induced by replication inhibition in mammalian cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779653

Evidence for BLM and Topoisomerase IIIalpha interaction in genomic stability

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779653

Regulation and localization of the Bloom syndrome protein in response to DNA damage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779653

Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779653

Binding and melting of D-loops by the Bloom syndrome helicase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779653

Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779653

Initiation of genetic recombination and recombination-dependent replication

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779653

Transfection of BLM into cultured bloom syndrome cells reduces the sister-chromatid exchange rate toward normal

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779653

A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779653

5-Bromodeoxyuridine-dependent increase in sister chromatid exchange formation in Bloom's syndrome is associated with reduction in topoisomerase II activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779653

Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forks

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779653

Molecular evidence that homologous recombination occurs in proliferating human somatic cells

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779653

Sister Chromatid Exchange and Chromosome Aberration Analysis With the Use of Several Carcinogens and Noncarcinogens: Brief Communication

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779653

Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p

21 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000252

Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000252

ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000252

Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000252

Dynamics of component exchange at PML nuclear bodies

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000252

Small ubiquitin-related modifier (SUMO) binding determines substrate recognition and paralog-selective SUMO modification

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000252

Rad52 sumoylation and its involvement in the efficient induction of homologous recombination

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000252

Cytokinesis-block micronucleus cytome assay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000252

SUMO: The Glue that Binds

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000252

Enhancement of induced sister chromatid exchange and chromosomal aberrations by inhibitors of DNA repair processes

21 January 2018

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12 December 2020

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin

1 reference

12 December 2020

Purification of overexpressed hexahistidine-tagged BLM N431 as oligomeric complexes

1 reference

12 December 2020

Role for BLM in replication-fork restart and suppression of origin firing after replicative stress

1 reference

12 December 2020

10.1371/JOURNAL.PBIO.1000252

Identifiers

DOI

1 reference

18 October 2017

1 reference

18 October 2017

PubMed publication ID

19956565

1 reference