Mammalian target of rapamycin complex 1 activation negatively regulates Polo-like kinase 2-mediated homeostatic compensation following neonatal seizures. (Q30538200)

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English	Mammalian target of rapamycin complex 1 activation negatively regulates Polo-like kinase 2-mediated homeostatic compensation following neonatal seizures.	scientific article

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25 February 2020

Mammalian target of rapamycin complex 1 activation negatively regulates Polo-like kinase 2-mediated homeostatic compensation following neonatal seizures (English)

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25 February 2020

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25 February 2020

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Hongyu Sun

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25 February 2020

Bela Kosaras

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25 February 2020

Frances E Jensen

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11 March 2013

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Proceedings of the National Academy of Sciences of the United States of America

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25 February 2020

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The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of rapamycin (mTOR) pathway

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20 June 2018

Hypoxia-induced neonatal seizures diminish silent synapses and long-term potentiation in hippocampal CA1 neurons

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Pattern of trauma determines the threshold for epileptic activity in a model of cortical deafferentation

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Incidence of epilepsy: a systematic review and meta-analysis.

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Rapamycin suppresses axon sprouting by somatostatin interneurons in a mouse model of temporal lobe epilepsy

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Plk2 Raps up Ras to subdue synapses

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Too Many Cooks? Intrinsic and Synaptic Homeostatic Mechanisms in Cortical Circuit Refinement

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Development of later life spontaneous seizures in a rodent model of hypoxia‐induced neonatal seizures

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Rapamycin Suppresses Mossy Fiber Sprouting But Not Seizure Frequency in a Mouse Model of Temporal Lobe Epilepsy

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Epilepsy, cognition, and behavior: The clinical picture

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Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation

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Unraveling mechanisms of homeostatic synaptic plasticity

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Ras and Rap signaling in synaptic plasticity and mental disorders

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20 June 2018

Recurrent neonatal seizures result in long-term increases in neuronal network excitability in the rat neocortex.

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The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions

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20 June 2018

Neonatal seizures: an update on mechanisms and management

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Epileptogenesis in the immature brain: emerging mechanisms

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Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy

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Identification of Polo-like kinase 1 as a potential therapeutic target in anaplastic thyroid carcinoma

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Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system

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The self-tuning neuron: synaptic scaling of excitatory synapses

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Regulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons

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20 June 2018

Early alterations of AMPA receptors mediate synaptic potentiation induced by neonatal seizures

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NMDA receptor blockade with memantine attenuates white matter injury in a rat model of periventricular leukomalacia

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Activity-induced Polo-like kinase 2 is required for homeostatic plasticity of hippocampal neurons during epileptiform activity

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The age of plasticity: developmental regulation of synaptic plasticity in neocortical microcircuits

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Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex.

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Impaired expression of postsynaptic density proteins in the hippocampal CA1 region of rats following perinatal hypoxia

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Persistently decreased basal synaptic inhibition of hippocampal CA1 pyramidal neurons after neonatal hypoxia-induced seizures

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20 June 2018

Polo-like kinases: a team in control of the division

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Polo-like kinases in the nervous system

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Translational regulatory mechanisms in persistent forms of synaptic plasticity

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Different forms of homeostatic plasticity are engaged with distinct temporal profiles

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Susceptibility for homeostatic plasticity is down-regulated in parallel with maturation of the rat hippocampal synaptic circuitry.

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10.1073/PNAS.1208010110

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25 February 2020

2013PNAS..110.5199S

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25 February 2020

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