Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis (Q30497751)

1 October 2017

Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis (English)

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1 October 2017

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Gerd Multhaup

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1 October 2017

Martin Ingelsson

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1 October 2017

Inge Huitinga

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1 October 2017

Lars Lannfelt

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1 October 2017

Oliver Wirths

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1 October 2017

Christian Erck

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1 October 2017

Henrik Martens

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1 October 2017

Anja Harmeier

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1 October 2017

Constanze Geumann

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1 October 2017

Sadim Jawhar

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1 October 2017

Sathish Kumar

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1 October 2017

Jochen Walter

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1 October 2017

Malin Degerman-Gunnarsson

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1 October 2017

Hannu Kalimo

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1 October 2017

Thomas A Bayer

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1 October 2017

language of work or name

English

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publication date

22 October 2010

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Journal of Biological Chemistry

1 October 2017

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1 October 2017

285

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1 October 2017

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1 October 2017

41517-41524

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describes a project that uses

1 October 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3009878/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Structure-neurotoxicity relationships of amyloid beta-protein oligomers

20 June 2018

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Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

20 June 2018

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Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta

20 June 2018

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Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

20 June 2018

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A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

20 June 2018

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Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

20 June 2018

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A specific amyloid-beta protein assembly in the brain impairs memory

20 June 2018

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Amyloid beta-peptide: the inside story

20 June 2018

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Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

20 June 2018

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A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade

20 June 2018

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Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model

20 June 2018

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Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

20 June 2018

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

20 June 2018

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20 June 2018

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Alzheimer's disease is a synaptic failure

20 June 2018

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Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets

20 June 2018

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20 June 2018

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Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.

21 January 2018

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Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology

21 January 2018

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Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo

21 January 2018

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High-molecular-weight beta-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients

21 January 2018

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Passive immunization against beta-amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutation

21 January 2018

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Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease

21 January 2018

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Deficits in working memory and motor performance in the APP/PS1ki mouse model for Alzheimer's disease

21 January 2018

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A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.

21 January 2018

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The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice

21 January 2018

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Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease.

21 January 2018

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Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model

21 January 2018

1 reference

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Mass spectrometry of purified amyloid beta protein in Alzheimer's disease

26 November 2018

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The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain

26 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/20971852

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.178707

1 reference

1 October 2017

1 reference

1 October 2017

PubMed publication ID

20971852

1 reference