Aggregation and fibril morphology of the Arctic mutation of Alzheimer's Aβ peptide by CD, TEM, STEM and in situ AFM (Q30448740)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22750418%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

Aggregation and fibril morphology of the Arctic mutation of Alzheimer's Aβ peptide by CD, TEM, STEM and in situ AFM (English)

1 reference

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6 February 2020

1 reference

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6 February 2020

1 reference

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6 February 2020

1 reference

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6 February 2020

Alioscka A Sousa

0 references

Nils Norlin

1 reference

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6 February 2020

Magnus Hellberg

series ordinal

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6 February 2020

Gerhard Gröbner

series ordinal

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6 February 2020

Oleg N Antzutkin

series ordinal

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6 February 2020

publication date

28 June 2012

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Journal of Structural Biology

6 February 2020

published in

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6 February 2020

volume

180

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6 February 2020

issue

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6 February 2020

page(s)

174-189

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Recent progress in understanding Alzheimer's β-amyloid structures

6 February 2020

cites work

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β-Barrel topology of Alzheimer's β-amyloid ion channels

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Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering

20 June 2018

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Structural convergence among diverse, toxic beta-sheet ion channels

20 June 2018

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Polymorphism in Alzheimer Abeta amyloid organization reflects conformational selection in a rugged energy landscape

20 June 2018

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Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils

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Comparison of Alzheimer Abeta(1-40) and Abeta(1-42) amyloid fibrils reveals similar protofilament structures

20 June 2018

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Structure-neurotoxicity relationships of amyloid beta-protein oligomers

20 June 2018

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Influence of residue 22 on the folding, aggregation profile, and toxicity of the Alzheimer's amyloid beta peptide

20 June 2018

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Evidence for novel beta-sheet structures in Iowa mutant beta-amyloid fibrils

20 June 2018

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Dysregulation of calcium homeostasis in Alzheimer's disease

20 June 2018

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Abeta(1-40) fibril polymorphism implies diverse interaction patterns in amyloid fibrils.

20 June 2018

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Molecular structural basis for polymorphism in Alzheimer's -amyloid fibrils

20 June 2018

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Paired beta-sheet structure of an Abeta(1-40) amyloid fibril revealed by electron microscopy

20 June 2018

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Annular structures as intermediates in fibril formation of Alzheimer Abeta17-42

20 June 2018

1 reference

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Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease

20 June 2018

1 reference

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Stabilization of a -hairpin in monomeric Alzheimer's amyloid- peptide inhibits amyloid formation

20 June 2018

1 reference

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Stepwise dynamics of epitaxially growing single amyloid fibrils

20 June 2018

1 reference

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Solid-state NMR spectroscopy of amyloid proteins

20 June 2018

1 reference

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Protofibril assemblies of the arctic, Dutch, and Flemish mutants of the Alzheimer's Abeta1-40 peptide

20 June 2018

1 reference

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Quantitative STEM mass measurement of biological macromolecules in a 300 kV TEM.

20 June 2018

1 reference

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Sensitive ELISA detection of amyloid-beta protofibrils in biological samples

20 June 2018

1 reference

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Amyloid beta ion channel: 3D structure and relevance to amyloid channel paradigm

20 June 2018

1 reference

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Molecular structure of amyloid fibrils: insights from solid-state NMR.

20 June 2018

1 reference

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Mechanical manipulation of Alzheimer's amyloid beta1-42 fibrils.

20 June 2018

1 reference

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Evidence that Perutz's double-beta-stranded subunit structure for beta-amyloids also applies to their channel-forming structures in membranes

20 June 2018

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Amyloid-beta aggregates formed at polar-nonpolar interfaces differ from amyloid-beta protofibrils produced in aqueous buffers

20 June 2018

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Amyloid ion channels: a common structural link for protein-misfolding disease

20 June 2018

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Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils

20 June 2018

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DICHROWEB, an online server for protein secondary structure analyses from circular dichroism spectroscopic data

20 June 2018

1 reference

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Elasticity and adhesion force mapping reveals real-time clustering of growth factor receptors and associated changes in local cellular rheological properties

20 June 2018

1 reference

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Amyloidosis of Alzheimer's Abeta peptides: solid-state nuclear magnetic resonance, electron paramagnetic resonance, transmission electron microscopy, scanning transmission electron microscopy and atomic force microscopy studies

20 June 2018

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Characterization by atomic force microscopy of Alzheimer paired helical filaments under physiological conditions

20 June 2018

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Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores.

20 June 2018

1 reference

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Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta

20 June 2018

1 reference

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466396

In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis

20 June 2018

1 reference

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A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR

20 June 2018

1 reference

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

20 June 2018

1 reference

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Amyloid beta protein forms ion channels: implications for Alzheimer's disease pathophysiology

20 June 2018

1 reference

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The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

20 June 2018

1 reference

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Multiple quantum solid-state NMR indicates a parallel, not antiparallel, organization of beta-sheets in Alzheimer's beta-amyloid fibrils

20 June 2018

1 reference

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Fresh and nonfibrillar amyloid beta protein(1-40) induces rapid cellular degeneration in aged human fibroblasts: evidence for AbetaP-channel-mediated cellular toxicity

20 June 2018

1 reference

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Fresh and globular amyloid beta protein (1-42) induces rapid cellular degeneration: evidence for AbetaP channel-mediated cellular toxicity

20 June 2018

1 reference

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Amyloid beta protein (1-40) forms calcium-permeable, Zn2+-sensitive channel in reconstituted lipid vesicles

20 June 2018

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Evolution of amyloid: what normal protein folding may tell us about fibrillogenesis and disease

20 June 2018

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Alzheimer's disease amyloid beta-protein forms Zn(2+)-sensitive, cation-selective channels across excised membrane patches from hypothalamic neurons

20 June 2018

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Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum

20 June 2018

1 reference

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Mass analysis of biological macromolecular complexes by STEM.

20 June 2018

1 reference

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Aggregation of amyloid Abeta((1-40)) peptide in perdeuterated 2,2,2-trifluoroethanol caused by ultrasound sonication.

20 June 2018

1 reference

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In situ Abeta pores in AD brain are cylindrical assembly of Abeta protofilaments

26 November 2018

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Evidence of fibril-like β-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's β-amyloid.

26 November 2018

1 reference

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High resolution scanning tunnelling microscopy of the beta-amyloid protein (Abeta1-40) of Alzheimer's disease suggests a novel mechanism of oligomer assembly.

26 November 2018

1 reference

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Capturing intermediate structures of Alzheimer's beta-amyloid, Abeta(1-40), by solid-state NMR spectroscopy

26 November 2018

1 reference

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Direct observation of Abeta amyloid fibril growth and inhibition

26 November 2018

1 reference

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Unique physicochemical profile of beta-amyloid peptide variant Abeta1-40E22G protofibrils: conceivable neuropathogen in arctic mutant carriers

26 November 2018

1 reference

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A left-handed 3(1) helical conformation in the Alzheimer Abeta(12-28) peptide.

26 November 2018

1 reference

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Self-assembly of Abeta(1-42) into globular neurotoxins.

26 November 2018

1 reference

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Alternate aggregation pathways of the Alzheimer beta-amyloid peptide: Abeta association kinetics at endosomal pH.

26 November 2018

1 reference

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Supramolecular structural constraints on Alzheimer's beta-amyloid fibrils from electron microscopy and solid-state nuclear magnetic resonance.

26 November 2018

1 reference

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Assembly of amyloid protofibrils via critical oligomers--a novel pathway of amyloid formation

26 November 2018

1 reference

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Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes

26 November 2018

1 reference

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Imaging real-time aggregation of amyloid beta protein (1-42) by atomic force microscopy.

26 November 2018

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Neurodegenerative disease: amyloid pores from pathogenic mutations

26 November 2018

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Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

26 November 2018

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Beta(2)-microglobulin and its deamidated variant, N17D form amyloid fibrils with a range of morphologies in vitro

26 November 2018

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Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis

26 November 2018

1 reference

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The molecular chaperone alphaB-crystallin enhances amyloid beta neurotoxicity

26 November 2018

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Assembly of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's disease

26 November 2018

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Observation of metastable Abeta amyloid protofibrils by atomic force microscopy

26 November 2018

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12 December 2020

Watching amyloid fibrils grow by time-lapse atomic force microscopy

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12 December 2020

Dipolar recoupling NMR of biomolecular self-assemblies: determining inter- and intrastrand distances in fibrilized Alzheimer's beta-amyloid peptide

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12 December 2020

Structural studies of soluble oligomers of the Alzheimer beta-amyloid peptide

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12 December 2020

In-situ atomic force microscopy study of β-amyloid fibrillization

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12 December 2020

Amyloid Fibril Formation from Full-Length and Fragments of Amylin

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Multiple assembly pathways underlie amyloid-beta fibril polymorphisms

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β-Sheet Structured β-Amyloid(1-40) Perturbs Phosphatidylcholine Model Membranes

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10.1016/J.JSB.2012.06.010

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22750418%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22750418%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

22750418

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22750418%20AND%20SRC:MED&resulttype=core&format=json