uPAR induces expression of transforming growth factor β and interleukin-4 in cancer cells to promote tumor-permissive conditioning of macrophages. (Q30365899)

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English	uPAR induces expression of transforming growth factor β and interleukin-4 in cancer cells to promote tumor-permissive conditioning of macrophages.	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

uPAR induces expression of transforming growth factor β and interleukin-4 in cancer cells to promote tumor-permissive conditioning of macrophages. (English)

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Andrew S. Gilder

4

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

author name string

Jingjing Hu

1

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Minji Jo

2

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Boryana M Eastman

3

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Jack D Bui

5

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Steven L Gonias

6

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

language of work or name

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publication date

11 October 2014

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

The American Journal of Pathology

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Europe PubMed Central

PMC publication ID

14 October 2017

184

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

12

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

3384-3393

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

The cellular and molecular origin of tumor-associated macrophages

1 reference

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3 June 2018

The M1 and M2 paradigm of macrophage activation: time for reassessment

1 reference

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3 June 2018

Myeloid cell receptor LRP1/CD91 regulates monocyte recruitment and angiogenesis in tumors

1 reference

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3 June 2018

A transformation in the mechanism by which the urokinase receptor signals provides a selection advantage for estrogen receptor-expressing breast cancer cells in the absence of estrogen

1 reference

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3 June 2018

Mouse forestomach carcinoma cells immunosuppress macrophages through transforming growth factor-β1.

1 reference

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3 June 2018

Targeting EGFR for treatment of glioblastoma: molecular basis to overcome resistance.

1 reference

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Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells

1 reference

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3 June 2018

TGF-β-induced IRAK-M expression in tumor-associated macrophages regulates lung tumor growth

1 reference

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3 June 2018

Cell Signaling by Urokinase-type Plasminogen Activator Receptor Induces Stem Cell–like Properties in Breast Cancer Cells

1 reference

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3 June 2018

The polarization of immune cells in the tumour environment by TGFbeta

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Mutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence

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CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages

1 reference

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3 June 2018

The urokinase receptor promotes cancer metastasis independently of urokinase-type plasminogen activator in mice

1 reference

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3 June 2018

The isolation and characterization of murine macrophages

1 reference

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3 June 2018

Determination of mammalian arginase activity

1 reference

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3 June 2018

Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression

1 reference

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3 June 2018

uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4258500

3 June 2018

uPAR-induced cell adhesion and migration: vitronectin provides the key

1 reference

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3 June 2018

Macrophages regulate the angiogenic switch in a mouse model of breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4258500

3 June 2018

Classical and alternative activation of mononuclear phagocytes: picking the best of both worlds for tumor promotion

1 reference

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3 June 2018

Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer

1 reference

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3 June 2018

Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells

1 reference

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3 June 2018

Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4258500

3 June 2018

Regulation of immune responses by L-arginine metabolism

1 reference

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3 June 2018

Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4258500

3 June 2018

Cancer and the chemokine network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4258500

3 June 2018

Clinical significance of urokinase-type plasminogen activator receptor (uPAR) expression in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4258500

3 June 2018

Inflammation and cancer

1 reference

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3 June 2018

Tumor-associated macrophages in breast cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4258500

3 June 2018

uPAR: a versatile signalling orchestrator

1 reference

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3 June 2018

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

1 reference

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Endogenously produced urokinase-type plasminogen activator is a major determinant of the basal level of activated ERK/MAP kinase and prevents apoptosis in MDA-MB-231 breast cancer cells.

1 reference

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Plasminogen activator inhibitor 1 functions as a urokinase response modifier at the level of cell signaling and thereby promotes MCF-7 cell growth

1 reference

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Rac mediates cytoskeletal rearrangements and increased cell motility induced by urokinase-type plasminogen activator receptor binding to vitronectin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4258500

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Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity

1 reference

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Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth.

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Infections as a major preventable cause of human cancer

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Activated alpha 2-macroglobulin reverses the immunosuppressive activity in human breast cancer cell-conditioned medium by selectively neutralizing transforming growth factor-beta in the presence of interleukin-2.

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Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility

1 reference

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The urokinase-type plasminogen activator system in cancer metastasis: A review

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TGF-beta 1 modulation of urokinase and PAI-1 expression in human bronchial epithelial cells

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Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor

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Inhibition of TGF-β signaling in combination with TLR7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4258500

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Tumor-associated macrophages press the angiogenic switch in breast cancer.

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The urokinase receptor is expressed in invasive breast cancer but not in normal breast tissue.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4258500

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Requirement for receptor-bound urokinase in plasmin-dependent cellular conversion of latent TGF-beta to TGF-beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/25310970

12 December 2020

based on heuristic

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Evaluation of urokinase plasminogen activator and its receptor in different grades of human prostate cancer☆

1 reference

https://pubmed.ncbi.nlm.nih.gov/25310970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/25310970

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A Paracrine Loop between Tumor Cells and Macrophages Is Required for Tumor Cell Migration in Mammary Tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25310970

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inferred from PubMed ID database lookup

Gastric cancer originating from bone marrow-derived cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25310970

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based on heuristic

inferred from PubMed ID database lookup

Inflammation and necrosis promote tumour growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/25310970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.AJPATH.2014.08.003

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

ResearchGate publication ID

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