Liver X Receptors Link Lipid Metabolism and Inflammation (Q30252316)

13 June 2017

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title

Liver X Receptors Link Lipid Metabolism and Inflammation (English)

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13 June 2017

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Ira G Schulman

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13 June 2017

language of work or name

English

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publication date

27 May 2017

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13 June 2017

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LXR, a nuclear receptor that defines a distinct retinoid response pathway

13 June 2017

volume

591

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issue

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page(s)

2978-2991

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cites work

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network

21 January 2018

1 reference

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Research resource: Comparative nuclear receptor atlas: basal and activated peritoneal B-1 and B-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor α in mouse liver reveals extensive sharing of binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Crystal structure of the heterodimeric complex of LXR and RXR ligand-binding domains in a fully agonistic conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Liver X receptors interact with corepressors to regulate gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Molecular determinants of the interactions between SRC‐1 and LXR/RXR heterodimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Potentiation of liver X receptor transcriptional activity by peroxisome-proliferator-activated receptor gamma co-activator 1 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Characterization of ASC-2 as an antiatherogenic transcriptional coactivator of liver X receptors in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Activating Signal Cointegrator 2 Required for Liver Lipid Metabolism Mediated by Liver X Receptors in Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Fatty acid binding profile of the liver X receptor α.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

High-level expression of ABCG5 and ABCG8 attenuates diet-induced hypercholesterolemia and atherosclerosis in Ldlr-/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Relative roles of ABCG5/ABCG8 in liver and intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Macrophage-independent regulation of reverse cholesterol transport by liver X receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

HDL cholesterol efflux capacity and incident cardiovascular events

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Role of LXRs in control of lipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

LXR-SREBP-1c-phospholipid transfer protein axis controls very low density lipoprotein (VLDL) particle size

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Synthetic LXR agonists increase LDL in CETP species

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Differential regulation of gene expression by LXRs in response to macrophage cholesterol loading

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Dissection of the insulin-sensitizing effect of liver X receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

The nuclear receptor LXR is a glucose sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Macrophages, inflammation, and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Macrophages in the pathogenesis of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Discovery of Highly Potent Liver X Receptor β Agonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXRβ

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Identification of macrophage liver X receptors as inhibitors of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Effect of macrophage overexpression of murine liver X receptor-alpha (LXR-alpha) on atherosclerosis in LDL-receptor deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Nanoparticles containing a liver X receptor agonist inhibit inflammation and atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Activation of liver X receptor decreases atherosclerosis in Ldlr⁻/⁻ mice in the absence of ATP-binding cassette transporters A1 and G1 in myeloid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Hypercholesterolemia and reduced HDL-C promote hematopoietic stem cell proliferation and monocytosis: studies in mice and FH children

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Regulation of hematopoietic stem and progenitor cell mobilization by cholesterol efflux pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

LXR signaling couples sterol metabolism to proliferation in the acquired immune response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Liver X receptors as integrators of metabolic and inflammatory signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Crosstalk between LXR and Toll-like Receptor Signaling Mediates Bacterial and Viral Antagonism of Cholesterol Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

LXR-dependent gene expression is important for macrophage survival and the innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Up-regulation of the ATP-binding cassette transporter A1 inhibits hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Liver X receptors agonists impede hepatitis C virus infection in an Idol-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Liver X receptor agonist inhibits HIV-1 replication and prevents HIV-induced reduction of plasma HDL in humanized mouse model of HIV infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Stimulation of the liver X receptor pathway inhibits HIV-1 replication via induction of ATP-binding cassette transporter A1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Stimulation of Liver X Receptor Has Potent Anti-HIV Effects in a Humanized Mouse Model of HIV Infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Coronin 2A mediates actin-dependent de-repression of inflammatory response genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

ABCA1 protein enhances Toll-like receptor 4 (TLR4)-stimulated interleukin-10 (IL-10) secretion through protein kinase A (PKA) activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

ATP-binding cassette transporter hallmarks tissue macrophages and modulates cytokine-triggered polarization programs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Deficiency of ATP-binding cassette transporters A1 and G1 in macrophages increases inflammation and accelerates atherosclerosis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Phenotypic polarization of macrophages in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Liver X receptor and STAT1 cooperate downstream of Gas6/Mer to induce anti-inflammatory arginase 2 expression in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

The arginase II gene is an anti-inflammatory target of liver X receptor in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

LXRα regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Mer signaling increases the abundance of the transcription factor LXR to promote the resolution of acute sterile inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRbeta and low blood-brain penetration

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Discovery and SAR of cinnolines/quinolines as liver X receptor (LXR) agonists with binding selectivity for LXRbeta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12702

Non-redundant roles for LXRalpha and LXRbeta in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5638683

Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5638683

Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARgamma-/-, PPARdelta-/-, PPARgammadelta-/-, or LXRalphabeta-/- bone marrow

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5638683

Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5638683

Macrophage liver X receptor is required for antiatherogenic activity of LXR agonists

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5638683

A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a).

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5638683

Apolipoprotein E-dependent cholesterol efflux from macrophages: kinetic study and divergent mechanisms for endogenous versus exogenous apolipoprotein E.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5638683

Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28555747

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Analysis of crystal structures of LXRbeta in relation to plasticity of the ligand-binding domain upon ligand binding

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28555747

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Macrophage, But Not Systemic, Apolipoprotein E Is Necessary for Macrophage Reverse Cholesterol Transport In Vivo

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28555747

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/1873-3468.12702

1 reference

13 June 2017

0 references

1 reference