Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis (Q30163857)

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English	Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

9 June 2017

Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis (English)

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Europe PubMed Central

PubMed publication ID

9 June 2017

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based on heuristic

inferred from title

metastatic colon cancer

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based on heuristic

inferred from title

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based on heuristic

inferred from title

object named as

Mei Yee Koh

2

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Christopher Cawthorne

object named as

Christopher Cawthorne

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Caroline Dive

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object named as

Paul Workman

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Europe PubMed Central

PubMed publication ID

9 June 2017

Valerie G Brunton

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object named as

Valerie G Brunton

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9 June 2017

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object named as

Margaret C Frame

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9 June 2017

author name string

Gareth J Griffiths

1

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9 June 2017

Natalie A Reeves

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9 June 2017

Martin Greaves

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9 June 2017

Michael J Tilby

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9 June 2017

D Graham Pearson

8

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9 June 2017

Christopher J Ottley

9

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9 June 2017

language of work or name

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publication date

23 August 2004

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9 June 2017

Journal of Biological Chemistry

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9 June 2017

279

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9 June 2017

44

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9 June 2017

46113-46121

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PubMed publication ID

9 June 2017

Biweekly chemotherapy with oxaliplatin, irinotecan, infusional Fluorouracil, and leucovorin: a pilot study in patients with metastatic colorectal cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Drug-target interactions: only the first step in the commitment to a programmed cell death?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Translating basic cancer research into new cancer therapeutics

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

v-Src generates a p53-independent apoptotic signal

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Dynamic coupling between the SH2 and SH3 domains of c-Src and Hck underlies their inactivation by C-terminal tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Reduced C-terminal Src kinase activity is correlated inversely with pp60(c-src) activity in colorectal carcinoma.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Activating SRC mutation in a subset of advanced human colon cancers

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https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

v-Src's hold over actin and cell adhesions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Selected glimpses into the activation and function of Src kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Shp-2 mediates v-Src-induced morphological changes and activation of the anti-apoptotic protein kinase Akt.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Activation and association of Stat3 with Src in v-Src-transformed cell lines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Stat3 activation by Src induces specific gene regulation and is required for cell transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Transforming growth factor-alpha prevents detachment-induced inhibition of c-Src kinase activity, Bcl-XL down-regulation, and apoptosis of intestinal epithelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Elevated c-Src is linked to altered cell-matrix adhesion rather than proliferation in KM12C human colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

STAT-1-independent upregulation of FADD and procaspase-3 and -8 in cancer cells treated with cytotoxic drugs.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95-mediated apoptosis by down-regulating FLIP-L expression.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Mitochondrial membrane permeabilisation by Bax/Bak

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

v-src induces cisplatin resistance by increasing the repair of cisplatin-DNA interstrand cross-links in human gallbladder adenocarcinoma cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Src tyrosine kinase augments taxotere-induced apoptosis through enhanced expression and phosphorylation of Bcl-2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Oncogenic transformation potentiates apoptosis, S-phase arrest and stress-kinase activation by etoposide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Expression of Fas ligand in liver metastases of human colonic adenocarcinomas

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Regulation of Btk by Src family tyrosine kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

The tyrosine kinase lck is required for CD95-independent caspase-8 activation and apoptosis in response to ionizing radiation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

The tyrosine kinase Lck is involved in regulation of mitochondrial apoptosis pathways.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Stat3 activation is required for cellular transformation by v-src

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Reduction of c-Src activity by substituted 5,7-diphenyl-pyrrolo[2,3-d]-pyrimidines induces osteoclast apoptosis in vivo and in vitro. Involvement of ERK1/2 pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408550200

21 January 2018

Identifiers

10.1074/JBC.M408550200

1 reference

Europe PubMed Central

PubMed publication ID

9 June 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 June 2017

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