Isoquinolin-1-one inhibitors of the MDM2-p53 interaction (Q39989774)

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English	Isoquinolin-1-one inhibitors of the MDM2-p53 interaction	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

18428185

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16 September 2017

title

Isoquinolin-1-one inhibitors of the MDM2-p53 interaction (English)

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Europe PubMed Central

PubMed publication ID

18428185

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16 September 2017

author

Anna Czarna

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Anna Czarna

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2

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Lutz Weber

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9

object named as

Lutz Weber

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Europe PubMed Central

PubMed publication ID

18428185

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16 September 2017

author name string

Ulli Rothweiler

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1

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Europe PubMed Central

PubMed publication ID

18428185

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16 September 2017

Marcin Krajewski

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3

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Europe PubMed Central

PubMed publication ID

18428185

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16 September 2017

Jolanta Ciombor

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4

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Europe PubMed Central

PubMed publication ID

18428185

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16 September 2017

Cédric Kalinski

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5

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Europe PubMed Central

PubMed publication ID

18428185

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16 September 2017

Vladimir Khazak

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6

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Europe PubMed Central

PubMed publication ID

18428185

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16 September 2017

Günther Ross

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7

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Europe PubMed Central

PubMed publication ID

18428185

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16 September 2017

Natalia Skobeleva

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8

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Europe PubMed Central

PubMed publication ID

18428185

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16 September 2017

Tad A Holak

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10

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Europe PubMed Central

PubMed publication ID

18428185

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16 September 2017

publication date

1 July 2008

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Europe PubMed Central

PubMed publication ID

18428185

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16 September 2017

published in

ChemMedChem

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Europe PubMed Central

PubMed publication ID

18428185

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16 September 2017

volume

3

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Europe PubMed Central

PubMed publication ID

18428185

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16 September 2017

issue

7

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Europe PubMed Central

PubMed publication ID

18428185

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16 September 2017

page(s)

1118-1128

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Europe PubMed Central

PubMed publication ID

18428185

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16 September 2017

cites work

Mapping of the p53 and mdm-2 Interaction Domains

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https://api.crossref.org/works/10.1002%2FCMDC.200800025

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21 January 2018

Molecular basis for the inhibition of p53 by Mdmx

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https://api.crossref.org/works/10.1002%2FCMDC.200800025

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21 January 2018

Cancer. p53, guardian of the genome

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7 January 2021

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Surfing the p53 network

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https://api.crossref.org/works/10.1002%2FCMDC.200800025

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7 January 2021

based on heuristic

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Live or let die: the cell's response to p53

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https://api.crossref.org/works/10.1002%2FCMDC.200800025

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7 January 2021

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Amplification of a gene encoding a p53-associated protein in human sarcomas

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https://api.crossref.org/works/10.1002%2FCMDC.200800025

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7 January 2021

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The p53-mdm-2 autoregulatory feedback loop

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https://api.crossref.org/works/10.1002%2FCMDC.200800025

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7 January 2021

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The p53-mdm2 autoregulatory feedback loop: a paradigm for the regulation of growth control by p53?

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7 January 2021

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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https://api.crossref.org/works/10.1002%2FCMDC.200800025

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7 January 2021

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Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.

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Crossref

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https://api.crossref.org/works/10.1002%2FCMDC.200800025

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7 January 2021

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The p53-Mdm2 module and the ubiquitin system.

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https://api.crossref.org/works/10.1002%2FCMDC.200800025

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7 January 2021

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The MDM2 gene amplification database

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https://api.crossref.org/works/10.1002%2FCMDC.200800025

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7 January 2021

based on heuristic

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Functions of the MDM2 oncoprotein

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https://api.crossref.org/works/10.1002%2FCMDC.200800025

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7 January 2021

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p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53.

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https://api.crossref.org/works/10.1002%2FCMDC.200800025

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7 January 2021

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A novel MDM2 anti-sense oligonucleotide has anti-tumor activity and potentiates cytotoxic drugs acting by different mechanisms in human colon cancer.

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https://api.crossref.org/works/10.1002%2FCMDC.200800025

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Antisense therapy targeting MDM2 oncogene in prostate cancer: Effects on proliferation, apoptosis, multiple gene expression, and chemotherapy

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7 January 2021

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Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

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Inhibiting the p53-MDM2 interaction: an important target for cancer therapy

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7 January 2021

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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7 January 2021

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Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

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https://api.crossref.org/works/10.1002%2FCMDC.200800025

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7 January 2021

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Patented small molecule inhibitors of p53-MDM2 interaction

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7 January 2021

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Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

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7 January 2021

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NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro

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https://api.crossref.org/works/10.1002%2FCMDC.200800025

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7 January 2021

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Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy.

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https://api.crossref.org/works/10.1002%2FCMDC.200800025

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7 January 2021

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Monitoring the effects of antagonists on protein-protein interactions with NMR spectroscopy

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7 January 2021

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An NMR-based antagonist induced dissociation assay for targeting the ligand-protein and protein-protein interactions in competition binding experiments

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7 January 2021

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Calculating similarities between biological activities in the MDL Drug Data Report database

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7 January 2021

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LIGSITEcsc: predicting ligand binding sites using the Connolly surface and degree of conservation

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7 January 2021

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Condensation of imines with homophthalic anhydrides. A convergent synthesis of cis- and trans-13-methyltetrahydroprotoberberines

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7 January 2021

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Lewis acid-induced reaction of homophthalic anhydride with imines: a convenient synthesis of trans-isoquinolonic acids

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https://api.crossref.org/works/10.1002%2FCMDC.200800025

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based on heuristic

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Synthesis of trans/cis 4-substituted 3-furyl-2-phenethyltetrahydroisoquinolin-1-ones: conformation of the trans-4-(pyrrolidinylcarbonyl) derivative

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Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53.

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https://api.crossref.org/works/10.1002%2FCMDC.200800025

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7 January 2021

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Inactivation of the p53 pathway in retinoblastoma.

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7 January 2021

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1) Ueber α-Alkylcinchoninsäuren und α-Alkylchinoline

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Crossref

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https://api.crossref.org/works/10.1002%2FCMDC.200800025

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

DOI

10.1002/CMDC.200800025

1 reference

stated in

Europe PubMed Central

PubMed publication ID

18428185

retrieved

16 September 2017

PubMed publication ID

18428185

1 reference

stated in

Europe PubMed Central

PubMed publication ID

18428185

retrieved

16 September 2017

 

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