Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression (Q39916287)

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English	Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

15 September 2017

Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression (English)

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Europe PubMed Central

PubMed publication ID

15 September 2017

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Mark J. Crabtree

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Mark J Crabtree

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Keith M Channon

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Amy L Tatham

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15 September 2017

Yasir Al-Wakeel

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15 September 2017

Nicholas Warrick

4

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15 September 2017

Ashley B Hale

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15 September 2017

Shijie Cai

6

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15 September 2017

Nicholas J Alp

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15 September 2017

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publication date

14 November 2008

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15 September 2017

Journal of Biological Chemistry

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15 September 2017

284

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15 September 2017

2

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15 September 2017

1136-1144

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15 September 2017

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

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Hypercholesterolemia increases endothelial superoxide anion production

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Superoxide and peroxynitrite in atherosclerosis

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Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors

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Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells

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The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study

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Formation of a protonated trihydrobiopterin radical cation in the first reaction cycle of neuronal and endothelial nitric oxide synthase detected by electron paramagnetic resonance spectroscopy.

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21 January 2018

Origin of superoxide production by endothelial nitric oxide synthase

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Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.

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Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice

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Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers : evidence for a dysfunctional nitric oxide synthase

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Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.

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Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia

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Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimer

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Functional comparison of the endothelial nitric oxide synthase Glu298Asp polymorphic variants in human endothelial cells

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Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence

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Detection of intracellular superoxide formation in endothelial cells and intact tissues using dihydroethidium and an HPLC-based assay

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Radiochemical HPLC detection of arginine metabolism: measurement of nitric oxide synthesis and arginase activity in vascular tissue

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Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

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The role of tetrahydrobiopterin in superoxide generation from eNOS: enzymology and physiological implications.

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Endothelial nitric-oxide synthase. Expression in Escherichia coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation.

1 reference

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21 January 2018

Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression

1 reference

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21 January 2018

Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical

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21 January 2018

The reaction of no with superoxide

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21 January 2018

Oxidation of tetrahydrobiopterin by peroxynitrite: implications for vascular endothelial function

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21 January 2018

Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase.

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21 January 2018

Vitamin C Improves Endothelium-Dependent Vasodilation in Patients With Insulin-Dependent Diabetes Mellitus

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MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial

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Formation of a Pterin Radical in the Reaction of the Heme Domain of Inducible Nitric Oxide Synthase with Oxygen†

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21 January 2018

Identifiers

10.1074/JBC.M805403200

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

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