Limits to thymidylate synthase and TP53 genes as predictive determinants for fluoropyrimidine sensitivity and further evidence for RNA-based toxicity as a major influence (Q39893194)

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English	Limits to thymidylate synthase and TP53 genes as predictive determinants for fluoropyrimidine sensitivity and further evidence for RNA-based toxicity as a major influence	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Limits to thymidylate synthase and TP53 genes as predictive determinants for fluoropyrimidine sensitivity and further evidence for RNA-based toxicity as a major influence (English)

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

10

object named as

Charles J Yeo

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Europe PubMed Central

PMC publication ID

15 September 2017

Michiel S. van der Heijden

7

object named as

Michiel S van der Heijden

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Europe PubMed Central

PMC publication ID

15 September 2017

author name string

Jonathan R Brody

1

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Europe PubMed Central

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15 September 2017

Tomas Hucl

2

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Europe PubMed Central

PMC publication ID

15 September 2017

Christina L Costantino

3

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Europe PubMed Central

PMC publication ID

15 September 2017

James R Eshleman

4

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Europe PubMed Central

PMC publication ID

15 September 2017

Eike Gallmeier

5

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Europe PubMed Central

PMC publication ID

15 September 2017

Heng Zhu

6

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Europe PubMed Central

PMC publication ID

15 September 2017

Jordan M Winter

8

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Europe PubMed Central

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15 September 2017

Agnieszka K Wikiewicz

9

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Europe PubMed Central

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15 September 2017

Scott E Kern

11

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15 September 2017

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publication date

20 January 2009

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Europe PubMed Central

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15 September 2017

Cancer Research

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Europe PubMed Central

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15 September 2017

69

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Europe PubMed Central

PMC publication ID

15 September 2017

3

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

984-991

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil. Is it time to move forward?

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Distinguishing rational from irrational applications of pharmacogenetic synergies from the bench to clinical trials

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Targeting Fanconi anemia/BRCA2 pathway defects in cancer: the significance of preclinical pharmacogenomic models

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Genomic copy number changes affecting the thymidylate synthase (TYMS) gene in cancer: a model for patient classification to aid fluoropyrimidine therapy

1 reference

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A proposed clinical test for monitoring fluoropyrimidine therapy: detection and stability of thymidylate synthase ternary complexes

1 reference

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Polymorphic tandem repeat sequences of the thymidylate synthase gene correlates with cellular-based sensitivity to fluoropyrimidine antitumor agents

1 reference

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Thymidylate synthase and dihydropyrimidine dehydrogenase gene expression in breast cancer predicts 5-FU sensitivity by a histocultural drug sensitivity test

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22 September 2017

Novel chemical strategies for thymidylate synthase inhibition

1 reference

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Gene expression profiling-based prediction of response of colon carcinoma cells to 5-fluorouracil and camptothecin.

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c-Myc overexpression sensitises colon cancer cells to camptothecin-induced apoptosis.

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Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression levels: predictors for survival in colorectal cancer patients receiving adjuvant 5-fluorouracil

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Reconstitution of an efficient thymidine salvage pathway in Saccharomyces cerevisiae

1 reference

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Fluorinated pyrimidines, a new class of tumour-inhibitory compounds

1 reference

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Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer

1 reference

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22 September 2017

5-Fluorouracil: mechanisms of action and clinical strategies

1 reference

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22 September 2017

Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism

1 reference

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A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil

1 reference

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5-Fluorouracil: forty-plus and still ticking. A review of its preclinical and clinical development

1 reference

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Disruption of p53 in human cancer cells alters the responses to therapeutic agents

1 reference

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22 September 2017

Ligand-mediated induction of thymidylate synthase occurs by enzyme stabilization. Implications for autoregulation of translation

1 reference

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Genetic instabilities in human cancers

1 reference

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22 September 2017

Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887094

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Treatment of cultured human colon carcinoma cells with fluorinated pyrimidines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887094

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5-Fluoro-2′-Deoxyuridylate: Covalent Complex with Thymidylate Synthetase

1 reference

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22 September 2017

Metabolism and mechanism of action of 5-fluorouracil

1 reference

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In vivo enhancement of 5-fluorouracil cytotoxicity to AKR leukemia cells by thymidine in mice

1 reference

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c-myc/p53 interaction determines sensitivity of human colon carcinoma cells to 5-fluorouracil in vitro and in vivo.

1 reference

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25 September 2017

Isolation and characterization of a thymidylate synthase-deficient human colon tumor cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887094

25 September 2017

Evidence that tRNA modifying enzymes are important in vivo targets for 5-fluorouracil in yeast

1 reference

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17 June 2018

Functional effects of amino acid substitutions at residue 33 of human thymidylate synthase.

1 reference

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17 June 2018

Functional effects of a naturally occurring amino acid substitution in human thymidylate synthase.

1 reference

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17 June 2018

Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887094

17 June 2018

Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil-sensitive and -resistant human cancer cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887094

17 June 2018

Effect of 5-fluorouracil on RNA metabolism in Novikoff hepatoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887094

17 June 2018

5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887094

20 August 2018

Relationships between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, and orotate phosphoribosyltransferase and cell proliferative activity and 5-fluorouracil sensitivity in colorectal carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887094

20 August 2018

Thymidylate synthase protein expression in primary colorectal cancer: lack of correlation with outcome and response to fluorouracil in metastatic disease sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887094

20 August 2018

Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887094

20 August 2018

High basal level gene expression of thymidine phosphorylase (platelet-derived endothelial cell growth factor) in colorectal tumors is associated with nonresponse to 5-fluorouracil.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887094

20 August 2018

The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887094

20 August 2018

Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/19155291

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uridine rescue from the lethal toxicity of 5-fluorouracil in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19155291

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunological quantitation of thymidylate synthase-FdUMP-5,10-methylenetetrahydrofolate ternary complex with the monoclonal antibody TS 106

1 reference

https://pubmed.ncbi.nlm.nih.gov/19155291

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Severe 5-fluorouracil toxicity in a patient with decreased dihydropyrimidine dehydrogenase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19155291

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth inhibition of a human tumor cell strain by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine; reversal studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/19155291

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for distinct DNA- and RNA-based mechanisms of 5-fluorouracil cytotoxicity in Saccharomyces cerevisiae

1 reference

https://pubmed.ncbi.nlm.nih.gov/19155291

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of RNA- and DNA-directed actions of 5-fluoropyrimidines in mouse T-lymphoma (S-49) cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19155291

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low-level c-myc amplification in human colonic carcinoma cell lines and tumors: a frequent, p53-independent mutation associated with improved outcome in a randomized multi-institutional trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/19155291

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-08-3610

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

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