Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus (Q39881582)

15 September 2017

title

Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus (English)

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Streptomyces hygroscopicus

15 September 2017

main subject

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[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13,19-dihydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(22),4,6,10,18,20-hexaen-9-yl] carbamate

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[(4E,8S,9S,10E,12S,13R,14S,16R)-20-chloro-13,19,22-trihydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate

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Carbamic acid (4E,10E)-(8S,9S,12S,13R,14S,16R)-13,19-dihydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3-oxo-2-aza-bicyclo[16.3.1]docosa-1(22),4,10,18,20-pentaen-9-yl ester

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Carbamic acid (4E,10E)-(8S,9S,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3-oxo-2-aza-bicyclo[16.3.1]docosa-1(22),4,10,18,20-pentaen-9-yl ester

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Carbamic acid (4E,6Z,10E)-(8S,9S,12S,13R,14S,16R)-13,19-dihydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3-oxo-2-aza-bicyclo[16.3.1]docosa-1(22),4,6,10,18,20-hexaen-9-yl ester

1 reference

Carbamic acid (4E,10E)-(8S,9S,12S,13R,14S,16R)-20-chloro-13,19-dihydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3-oxo-2-aza-bicyclo[16.3.1]docosa-1(22),4,10,18,20-pentaen-9-yl ester

1 reference

[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-20-chloro-13,19,22-trihydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate

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Hugo G Menzella

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15 September 2017

Thomas-Toan Tran

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15 September 2017

John R Carney

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15 September 2017

Janice Lau-Wee

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15 September 2017

Jorge Galazzo

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15 September 2017

Christopher D Reeves

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15 September 2017

Christopher Carreras

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15 September 2017

Sophie Mukadam

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15 September 2017

Sara Eng

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15 September 2017

Ziyang Zhong

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15 September 2017

Pieter B M W M Timmermans

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15 September 2017

Sumati Murli

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15 September 2017

Gary W Ashley

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Journal of Medicinal Chemistry

15 September 2017

language of work or name

English

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publication date

20 February 2009

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16 September 2022

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15 September 2017

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15 September 2017

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15 September 2017

page(s)

1518-1521

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Reblastatin, a novel benzenoid ansamycin-type cell cycle inhibitor

15 September 2017

cites work

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12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.53.1310

Directed biosynthesis of 5"-fluoropactamycin in Streptomyces pactum

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.47.1456

Identifiers

DOI

10.1021/JM900012A

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15 September 2017

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