The oral iron chelator deferasirox represses signaling through the mTOR in myeloid leukemia cells by enhancing expression of REDD1. (Q39870984)

15 September 2017

title

The oral iron chelator deferasirox represses signaling through the mTOR in myeloid leukemia cells by enhancing expression of REDD1. (English)

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15 September 2017

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Kazuma Ohyashiki

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15 September 2017

Junko H Ohyashiki

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15 September 2017

Chiaki Kobayashi

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15 September 2017

Ryoko Hamamura

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15 September 2017

Seiichi Okabe

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15 September 2017

Tetsuzo Tauchi

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15 September 2017

language of work or name

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9 March 2009

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15 September 2017

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15 September 2017

volume

100

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15 September 2017

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15 September 2017

page(s)

970-977

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Forging a field: the golden age of iron biology

15 September 2017

cites work

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Iron chelators deferoxamine and diethylenetriamine pentaacetic acid induce apoptosis in ovarian carcinoma

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21 January 2018

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Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod

21 January 2018

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21 January 2018

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21 January 2018

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Antiproliferative and apoptotic effects in rat and human hepatoma cell cultures of the orally active iron chelator ICL670 compared to CP20: a possible relationship with polyamine metabolism

21 January 2018

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The new orally active iron chelator ICL670A exhibits a higher antiproliferative effect in human hepatocyte cultures than O-trensox

21 January 2018

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A safety, pharmacokinetic and pharmacodynamic investigation of deferasirox (Exjade, ICL670) in patients with transfusion-dependent anemias and iron-overload: a Phase I study in Japan

21 January 2018

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Iron chelation and regulation of the cell cycle: 2 mechanisms of posttranscriptional regulation of the universal cyclin-dependent kinase inhibitor p21CIP1/WAF1 by iron depletion

21 January 2018

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Iron regulates T-lymphocyte sensitivity to the IFN-gamma/STAT1 signaling pathway in vitro and in vivo

21 January 2018

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Deferoxamine enhances anti-proliferative effect of interferon-gamma against hepatocellular carcinoma cells

21 January 2018

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REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase.

21 January 2018

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Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1.

21 January 2018

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TSC2: filling the GAP in the mTOR signaling pathway

21 January 2018

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The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway

21 January 2018

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Hypoxic condition- and high cell density-induced expression of Redd1 is regulated by activation of hypoxia-inducible factor-1alpha and Sp1 through the phosphatidylinositol 3-kinase/Akt signaling pathway.

21 January 2018

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Hypoxia signalling through mTOR and the unfolded protein response in cancer

21 January 2018

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Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis.

21 January 2018

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10.1111/J.1349-7006.2009.01131.X

21 January 2018

Identifiers

DOI

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15 September 2017

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