Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents (Q39699084)

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English	Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents	scientific article

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Europe PubMed Central

PMC publication ID

14 September 2017

Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents (English)

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Europe PubMed Central

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14 September 2017

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Detlev Schindler

16

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Detlev Schindler

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14 September 2017

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Andreas Palagyi

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Kornelia Neveling

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Ursula Plinninger

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Andreas Ziesch

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Bianca-Sabrina Targosz

5

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Gerald U Denk

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Stephanie Ochs

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Antonia Rizzani

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Daniel Meier

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Wolfgang E Thasler

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Helmut Hanenberg

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Enrico N De Toni

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Florian Bassermann

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Claus Schäfer

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Burkhard Göke

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Eike Gallmeier

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publication date

28 May 2010

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Molecular Cancer

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9

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127

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14 September 2017

PICNIC: an algorithm to predict absolute allelic copy number variation with microarray cancer data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

DNA damage detection and repair pathways--recent advances with inhibitors of checkpoint kinases in cancer therapy

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14 September 2017

Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Genetic heterogeneity among Fanconi anemia heterozygotes and risk of cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Distinguishing rational from irrational applications of pharmacogenetic synergies from the bench to clinical trials

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

FANCI is a second monoubiquitinated member of the Fanconi anemia pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Targeting Fanconi anemia/BRCA2 pathway defects in cancer: the significance of preclinical pharmacogenomic models

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Systematic review: evidence-based management of hepatocellular carcinoma--an updated analysis of randomized controlled trials.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

BRCA1 and BRCA2 pathways and the risk of cancers other than breast or ovarian

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Genetics of the FANCA gene in familial pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Androgens and liver tumors: Fanconi's anemia and non-Fanconi's conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Functional defects in the fanconi anemia pathway in pancreatic cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Promoter hypermethylation of FANCF: disruption of Fanconi Anemia-BRCA pathway in cervical cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival

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14 September 2017

Cancer in Fanconi anemia, 1927-2001

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

The Fanconi anaemia/BRCA pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Spectrum of mutations in the Fanconi anaemia group G gene, FANCG/XRCC9

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

High frequency of large intragenic deletions in the Fanconi anemia group A gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

RAD51 Interacts with the Evolutionarily Conserved BRC Motifs in the Human Breast Cancer Susceptibility Gene brca2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Characterisation of the exon structure of the Fanconi anaemia group C gene by vectorette PCR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Growth of human hepatoma cells lines with differentiated functions in chemically defined medium

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Hepatic lesions in patients treated with synthetic anabolic steriods

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14 September 2017

Disruption of the FA/BRCA pathway in bladder cancer

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14 September 2017

Gene-specific selection against experimental fanconi anemia gene inactivation in human cancer

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14 September 2017

Identifying allelic loss and homozygous deletions in pancreatic cancer without matched normals using high-density single-nucleotide polymorphism arrays

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14 September 2017

Targeted disruption of FANCC and FANCG in human cancer provides a preclinical model for specific therapeutic options

1 reference

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14 September 2017

BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Inducibility of nuclear Rad51 foci after DNA damage distinguishes all Fanconi anemia complementation groups from D1/BRCA2.

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14 September 2017

Absence of specific cell killing of the BRCA2-deficient human cancer cell line CAPAN1 by poly(ADP-ribose) polymerase inhibition

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

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14 September 2017

ATR couples FANCD2 monoubiquitination to the DNA-damage response

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14 September 2017

Charitable State-Controlled Foundation Human Tissue and Cell Research: Ethic and Legal Aspects in the Supply of Surgically Removed Human Tissue For Research in the Academic and Commercial Sector in Germany

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14 September 2017

Functional screen of the fanconi anemia pathway in cancer cells by Fancd2 immunoblot

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

14 September 2017

Bi-allelic silencing of the Fanconi anaemia gene FANCF in acute myeloid leukaemia

1 reference

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14 September 2017

Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

25 September 2017

Frequent allelic loss on chromosome 9 in hepatocellular carcinoma.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

15 June 2018

A nonsense mutation and exon skipping in the Fanconi anaemia group C gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

15 June 2018

Association of androgenic-anabolic steroid therapy with development of hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

15 June 2018

Genotype-phenotype correlations in Fanconi anemia

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

20 August 2018

No evidence for FANCF gene silencing in head-and-neck squamous cell carcinomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

20 August 2018

Hypermethylation of the FANCC and FANCL promoter regions in sporadic acute leukaemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

20 August 2018

Identification of the Fanconi anemia complementation group I gene, FANCI.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

20 August 2018

The Fanconi anemia pathway of genomic maintenance.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

20 August 2018

BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

20 August 2018

The genetics of FANCC and FANCG in familial pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

20 August 2018

Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

20 August 2018

Diagnosis and Treatment of Hepatocellular Carcinoma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

20 August 2018

Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890608

2 December 2018

Germ line Fanconi anemia complementation group C mutations and pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20509860

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fanconi anemia gene mutations in young-onset pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20509860

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The association of nonsense codons with exon skipping

1 reference

https://pubmed.ncbi.nlm.nih.gov/20509860

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homozygous deletion map at 18q21.1 in pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20509860

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variation in cisplatinum sensitivity is not associated with Fanconi Anemia/BRCA pathway inactivation in head and neck squamous cell carcinoma cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/20509860

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-throughput screening identifies novel agents eliciting hypersensitivity in Fanconi pathway-deficient cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20509860

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Copy-number methods dramatically underestimate loss of heterozygosity in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20509860

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/20509860

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular pathogenesis of hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20509860

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1186/1476-4598-9-127

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https://scigraph.springernature.com/pub.10.1186/1476-4598-9-127

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