Sequential activation of NFAT and c-Myc transcription factors mediates the TGF-beta switch from a suppressor to a promoter of cancer cell proliferation (Q39697751)

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English	Sequential activation of NFAT and c-Myc transcription factors mediates the TGF-beta switch from a suppressor to a promoter of cancer cell proliferation	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

14 September 2017

Sequential activation of NFAT and c-Myc transcription factors mediates the TGF-beta switch from a suppressor to a promoter of cancer cell proliferation (English)

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

7

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Europe PubMed Central

PMC publication ID

14 September 2017

object named as

Thomas M Gress

8

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Martín E Fernández-Zapico

9

object named as

Martin E Fernandez-Zapico

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Europe PubMed Central

PMC publication ID

14 September 2017

author name string

Garima Singh

1

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Europe PubMed Central

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14 September 2017

Shiv K Singh

2

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Europe PubMed Central

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14 September 2017

Alexander König

3

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Europe PubMed Central

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14 September 2017

Kristina Reutlinger

4

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Europe PubMed Central

PMC publication ID

14 September 2017

Monica D Nye

5

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Europe PubMed Central

PMC publication ID

14 September 2017

Tillman Adhikary

6

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Europe PubMed Central

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14 September 2017

Volker Ellenrieder

10

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14 September 2017

language of work or name

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publication date

1 June 2010

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Europe PubMed Central

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14 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

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14 September 2017

285

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Europe PubMed Central

PMC publication ID

14 September 2017

35

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

27241-27250

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Europe PubMed Central

PMC publication ID

14 September 2017

Akt/protein kinase b and glycogen synthase kinase-3beta signaling pathway regulates cell migration through the NFAT1 transcription factor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930723

14 September 2017

Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition

1 reference

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14 September 2017

Dual roles for NFAT transcription factor genes as oncogenes and tumor suppressors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930723

14 September 2017

TGFbeta in Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930723

14 September 2017

TGFbeta regulated gene expression by Smads and Sp1/KLF-like transcription factors in cancer.

1 reference

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14 September 2017

Role of transforming growth factor-beta superfamily signaling pathways in human disease

1 reference

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14 September 2017

The calcineurin/NFAT signaling pathway: a novel therapeutic target in leukemia and solid tumors

1 reference

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14 September 2017

An emerging role for Ca2+/calcineurin/NFAT signaling in cancerogenesis

1 reference

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14 September 2017

Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer

1 reference

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14 September 2017

Escaping from the TGFbeta anti-proliferative control

1 reference

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14 September 2017

Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses

1 reference

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14 September 2017

Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-beta: implications for carcinogenesis.

1 reference

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14 September 2017

NFAT proteins: key regulators of T-cell development and function

1 reference

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14 September 2017

Role of transforming growth factor Beta in human cancer

1 reference

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14 September 2017

Activation and deactivation of gene expression by Ca2+/calcineurin-NFAT-mediated signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930723

14 September 2017

Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930723

14 September 2017

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930723

14 September 2017

The two faces of transforming growth factor beta in carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930723

14 September 2017

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

1 reference

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14 September 2017

E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

1 reference

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14 September 2017

The role of NFAT transcription factors in integrin-mediated carcinoma invasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930723

14 September 2017

Regulation of cell proliferation by Smad proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930723

14 September 2017

SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway

1 reference

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14 September 2017

TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930723

14 September 2017

Repression of p15INK4b expression by Myc through association with Miz-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930723

14 September 2017

Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930723

14 September 2017

TGFbeta signaling in growth control, cancer, and heritable disorders

1 reference

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14 September 2017

Role of transforming growth factor-beta signaling in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930723

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Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells.

1 reference

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14 September 2017

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

1 reference

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14 September 2017

Transcription factors of the NFAT family: regulation and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930723

14 September 2017

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930723

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p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

1 reference

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Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway

1 reference

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14 September 2017

Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.

1 reference

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25 September 2017

Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4.

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20 August 2018

Transforming growth factor beta 1 induces proliferation in colon carcinoma cells by Ras-dependent, smad-independent down-regulation of p21cip1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930723

20 August 2018

Altered expression of TGFB receptors and mitogenic effects of TGFB in pancreatic carcinomas

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930723

20 August 2018

Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/20516082

12 December 2020

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10.1074/JBC.M110.100438

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

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