Raloxifene induces cell death and inhibits proliferation through multiple signaling pathways in prostate cancer cells expressing different levels of estrogen receptor α and β. (Q39644350)

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scientific article published on May 2011

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English	Raloxifene induces cell death and inhibits proliferation through multiple signaling pathways in prostate cancer cells expressing different levels of estrogen receptor α and β.	scientific article published on May 2011

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15 February 2020

Raloxifene induces cell death and inhibits proliferation through multiple signaling pathways in prostate cancer cells expressing different levels of estrogen receptor α and β (English)

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15 February 2020

prostate cancer

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Ciro Abbondanza

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Fulvio Della Ragione

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Annamaria De Bellis

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V Rossi

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G Bellastella

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C De Rosa

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D Visconti

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D Prezioso

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A Bellastella

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A A Sinisi

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1 May 2011

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Journal of Cellular Physiology

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1334-1339

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15 February 2020

The retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action

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Loss of ERbeta expression as a common step in estrogen-dependent tumor progression

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21 January 2018

Estrogen and prostate cancer: an eclipsed truth in an androgen-dominated scenario

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Estrogen receptor-beta: implications for the prostate gland

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Par-4 transcriptionally regulates Bcl-2 through a WT1-binding site on the bcl-2 promoter

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Molecular regulation of androgen action in prostate cancer

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Selective estrogen receptor modulators (SERMS).

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The dual, opposing roles of estrogen in the prostate.

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Estimates of the cancer incidence and mortality in Europe in 2006.

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Increased expression of protease-activated receptor-2 (PAR2) and PAR4 in human coronary artery by inflammatory stimuli unveils endothelium-dependent relaxations to PAR2 and PAR4 agonists

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Estrogens and anti-estrogens: key mediators of prostate carcinogenesis and new therapeutic candidates

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Prostate phenotypes in estrogen-modulated transgenic mice.

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Cancer statistics, 2004

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Raloxifene, a mixed estrogen agonist/antagonist, induces apoptosis through cleavage of BAD in TSU-PR1 human cancer cells

1 reference

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21 January 2018

Reflections on the discovery and significance of estrogen receptor beta

1 reference

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21 January 2018

Comparative studies of the estrogen receptors beta and alpha and the androgen receptor in normal human prostate glands, dysplasia, and in primary and metastatic carcinoma

1 reference

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21 January 2018

Essential role for estrogen receptor beta in stromal-epithelial regulation of prostatic hyperplasia.

1 reference

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Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation

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Sex steroid hormones act as growth factors

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Retinoic acid inhibits the growth of bone marrow mesenchymal stem cells and induces p27Kip1 and p16INK4A up-regulation.

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17beta-estradiol inhibits apoptosis in MCF-7 cells, inducing bcl-2 expression via two estrogen-responsive elements present in the coding sequence.

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DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression

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Emerging roles of caspase-3 in apoptosis

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Mutually exclusive expression patterns of Bcl-2 and Par-4 in human prostate tumors consistent with down-regulation of Bcl-2 by Par-4.

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21 January 2018

Expression of RIZ1 protein (Retinoblastoma-interacting zinc-finger protein 1) in prostate cancer epithelial cells changes with cancer grade progression and is modulated in vitro by DHT and E2.

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21 January 2018

Raloxifene, an oestrogen-receptor-beta-targeted therapy, inhibits androgen-independent prostate cancer growth: results from preclinical studies and a pilot phase II clinical trial.

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EPN: a novel epithelial cell line derived from human prostate tissue

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Treatment-related osteoporosis in men with prostate cancer

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The evolving biology and treatment of prostate cancer

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Estrogen receptor beta in the prostate

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Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by raloxifene, an antiestrogen with anti-androgen action, but not nimesulide, a selective cyclooxygenase-2 inhibitor

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Apoptosis and tumor resistance conferred by Par-4

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Characterization and epitope mapping of a new panel of monoclonal antibodies to estradiol receptor

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Identification of a DNA Binding Protein Cooperating with Estrogen Receptor as RIZ (Retinoblastoma Interacting Zinc Finger Protein)

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Identifiers

10.1002/JCP.22461

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20945400%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20945400%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

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