p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1α pathways (Q39604806)

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scientific article published on December 10, 2010

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English	p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1α pathways	scientific article published on December 10, 2010

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scholarly article

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Europe PubMed Central

PubMed publication ID

13 September 2017

p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1α pathways (English)

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Europe PubMed Central

PubMed publication ID

13 September 2017

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hepatocellular carcinoma

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neoplastic invasiveness

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author name string

Jing Fu

1

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13 September 2017

Yao Chen

2

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13 September 2017

Jie Cao

3

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13 September 2017

Tao Luo

4

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13 September 2017

You-Wen Qian

5

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13 September 2017

Wen Yang

6

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13 September 2017

Yi-Bin Ren

7

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13 September 2017

Bo Su

8

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Guang-Wen Cao

9

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13 September 2017

Yuan Yang

10

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13 September 2017

Yi-Qun Yan

11

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13 September 2017

Feng Shen

12

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13 September 2017

Meng-Chao Wu

13

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13 September 2017

Gen-Sheng Feng

14

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13 September 2017

Hong-Yang Wang

15

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13 September 2017

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publication date

10 December 2010

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13 September 2017

full work available at URL

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhep.24015

1 reference

10.1002/HEP.24015

https://api.crossref.org/works/10.1002/HEP.24015

22 November 2024

https://journals.lww.com/01515467-201101000-00020

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10.1002/HEP.24015

https://api.crossref.org/works/10.1002/HEP.24015

22 November 2024

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Europe PubMed Central

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13 September 2017

53

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1

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181-192

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13 September 2017

Global cancer statistics, 2002

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A randomized phase III study of doxorubicin versus cisplatin/interferon alpha-2b/doxorubicin/fluorouracil (PIAF) combination chemotherapy for unresectable hepatocellular carcinoma.

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Biology of hepatocellular carcinoma

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Systematic review: evidence-based management of hepatocellular carcinoma--an updated analysis of randomized controlled trials.

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Molecular mechanisms of hepatocellular carcinoma

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Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas

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Overexpression of p28/gankyrin in human hepatocellular carcinoma and its clinical significance

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Role of a novel oncogenic protein, gankyrin, in hepatocyte proliferation

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Use of adenovirus-delivered siRNA to target oncoprotein p28GANK in hepatocellular carcinoma.

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The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53

1 reference

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p28GANK inhibits endoplasmic reticulum stress-induced cell death via enhancement of the endoplasmic reticulum adaptive capacity

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The oncoprotein gankyrin interacts with RelA and suppresses NF-kappaB activity

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21 January 2018

Oncoprotein p28 GANK binds to RelA and retains NF-kappaB in the cytoplasm through nuclear export

1 reference

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A decade's studies on metastasis of hepatocellular carcinoma

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Stepwise metastatic human hepatocellular carcinoma cell model system with multiple metastatic potentials established through consecutive in vivo selection and studies on metastatic characteristics

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HIF-1 and tumor progression: pathophysiology and therapeutics

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A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

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Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells

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Difference in tumor invasiveness in cirrhotic patients with hepatocellular carcinoma fulfilling the Milan criteria treated by resection and transplantation: impact on long-term survival

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Prospective analysis of risk factors for hepatocellular carcinoma in patients with liver cirrhosis

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Association of gankyrin protein expression with early clinical stages and insulin-like growth factor-binding protein 5 expression in human hepatocellular carcinoma

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Gankyrin oncoprotein overexpression as a critical factor for tumor growth in human esophageal squamous cell carcinoma and its clinical significance

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Overexpression of a novel gene gankyrin correlates with the malignant phenotype of colorectal cancer

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Expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor in hepatocellular carcinoma: Impact on neovascularization and survival

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Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

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Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

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Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways

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Metastasis and AKT activation

1 reference

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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Multiple proteasome-interacting proteins assist the assembly of the yeast 19S regulatory particle

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7 January 2021

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inferred from DOI database lookup

Occurrence of portal vein tumor thrombus in hepatocellular carcinoma affects prognosis and survival. A retrospective clinical study of 150 cases

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7 January 2021

based on heuristic

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Identifiers

10.1002/HEP.24015

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

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