Xenobiotic metabolism capacities of human skin in comparison with a 3D-epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: phase II enzymes (Q39363451)

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English	Xenobiotic metabolism capacities of human skin in comparison with a 3D-epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: phase II enzymes	scientific article

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scholarly article

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Europe PubMed Central

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11 September 2017

Xenobiotic metabolism capacities of human skin in comparison with a 3D-epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: phase II enzymes (English)

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Europe PubMed Central

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11 September 2017

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Ellen Fritsche

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11 September 2017

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Christine Götz

1

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Roland Pfeiffer

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Julia Tigges

3

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Karsten Ruwiedel

4

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Ulrike Hübenthal

5

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Hans F Merk

6

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Jean Krutmann

7

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Robert J Edwards

8

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Josef Abel

9

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Camilla Pease

10

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Carsten Goebel

11

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Nicola Hewitt

12

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11 September 2017

publication date

1 May 2012

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11 September 2017

Experimental Dermatology

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21

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5

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11 September 2017

364-369

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11 September 2017

Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction

1 reference

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Skin: major target organ of allergic reactions to small molecular weight compounds

1 reference

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Metabolic activation in drug allergies.

1 reference

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Xenobiotic metabolism gene expression in the EpiDermin vitro 3D human epidermis model compared to human skin

1 reference

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Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line

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Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo

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The ontogeny of human drug-metabolizing enzymes: phase II conjugation enzymes and regulatory mechanisms

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Sulforaphane but not ascorbigen, indole-3-carbinole and ascorbic acid activates the transcription factor Nrf2 and induces phase-2 and antioxidant enzymes in human keratinocytes in culture.

1 reference

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Inhibition of uridinediphosphate glucuronyltransferase caused by furosemide.

1 reference

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Peroxynitrite irreversibly inactivates the human xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1) in human breast cancer cells: a cellular and mechanistic study

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Glutathione S-transferase polymorphisms and their biological consequences

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Short communication direct effect of Cd on glutathione S-transferase and glutathione reductase from Calystegia sepium

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Postnatal development of hepatic oxidative, hydrolytic and conjugative drug-metabolizing enzymes in female horses

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Human UDP-glucuronosyltransferases: metabolism, expression, and disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2012.01478.X

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The effect of incubation conditions on the enzyme kinetics of udp-glucuronosyltransferases

1 reference

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Human udp-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid

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Regulation of the activity of the human drug metabolizing enzyme arylamine N-acetyltransferase 1: role of genetic and non genetic factors

1 reference

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21 January 2018

Structure and regulation of the drug-metabolizing enzymes arylamine N-acetyltransferases

1 reference

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21 January 2018

Concise review of the glutathione S-transferases and their significance to toxicology

1 reference

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21 January 2018

Expression and regulation of glutathione S-transferase P1-1 in cultured human epidermal cells.

1 reference

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21 January 2018

Expression of multiple cytochrome p450 enzymes and multidrug resistance-associated transport proteins in human skin keratinocytes

1 reference

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21 January 2018

Cytochrome P450 expression in human keratinocytes: an aryl hydrocarbon receptor perspective

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21 January 2018

Glutathione S-transferase and glutathione peroxidase expression in normal and tumour human tissues

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Induction by xenobiotics of phase I and phase II enzyme activities in the human keratinocyte cell line NCTC 2544.

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21 January 2018

Natural and synthetic inhibitors of UDP-glucuronosyltransferase

1 reference

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21 January 2018

Metabolism of 3-indolylacetic acid during percutaneous absorption in human skin.

1 reference

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21 January 2018

Percutaneous penetration and dermal metabolism of triclosan (2,4, 4'-trichloro-2'-hydroxydiphenyl ether)

1 reference

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21 January 2018

Drug-metabolizing enzymes in the skin of man, rat, and pig.

1 reference

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21 January 2018

Human acetyl CoA:arylamine N-acetyltransferase variants generated by random mutagenesis

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Skin metabolism of aminophenols: human keratinocytes as a suitable in vitro model to qualitatively predict the dermal transformation of 4-amino-2-hydroxytoluene in vivo.

1 reference

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21 January 2018

Penetration of beta-naphthylamine and o-toluidine through human skin in vitro

1 reference

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Evaluation of cytochrome P450 1 (CYP1) and N-acetyltransferase 1 (NAT1) activities in HaCaT cells: implications for the development of in vitro techniques for predictive testing of contact sensitizers

1 reference

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Comparison of activities dependent on glutathione S-transferase and cytochrome P-450 IA1 in cultured keratinocytes and reconstructed epidermal models

1 reference

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Molecular basis for dimethylsulfoxide (DMSO) action on lipid membranes

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21 January 2018

Identifiers

10.1111/J.1600-0625.2012.01478.X

1 reference

Europe PubMed Central

PubMed publication ID

11 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 September 2017

ResearchGate publication ID

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