Immunotherapy of hepatocellular carcinoma using chimeric antigen receptors and bispecific antibodies (Q39253341)

10 September 2017

title

Immunotherapy of hepatocellular carcinoma using chimeric antigen receptors and bispecific antibodies (English)

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10 September 2017

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hepatocellular carcinoma

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inferred from title

author name string

Sayed Shahabuddin Hoseini

series ordinal

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10 September 2017

Nai-Kong V Cheung

series ordinal

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10 September 2017

language of work or name

English

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publication date

17 April 2017

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10 September 2017

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10 September 2017

volume

399

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10 September 2017

page(s)

44-52

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Intraperitoneal immunotherapy with T cells stably and transiently expressing anti-EpCAM CAR in xenograft models of peritoneal carcinomatosis

10 September 2017

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Overexpression of osteopontin promotes resistance to cisplatin treatment in HCC.

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30 August 2018

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Phase I Hepatic Immunotherapy for Metastases Study of Intra-Arterial Chimeric Antigen Receptor-Modified T-cell Therapy for CEA+ Liver Metastases

30 August 2018

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30 August 2018

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Osteopontin promotes a cancer stem cell-like phenotype in hepatocellular carcinoma cells via an integrin-NF-κB-HIF-1α pathway

30 August 2018

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30 August 2018

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30 August 2018

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30 August 2018

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30 August 2018

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Solitomab, an epithelial cell adhesion molecule/CD3 bispecific antibody (BiTE), is highly active against primary chemotherapy-resistant ovarian cancer cell lines in vitro and fresh tumor cells ex vivo

30 August 2018

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Molecular mechanism of hepatitis B virus-induced hepatocarcinogenesis

30 August 2018

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Serum anti-osteopontin autoantibody as a novel diagnostic and prognostic biomarker in patients with hepatocellular carcinoma.

30 August 2018

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Osteopontin as a therapeutic target for cancer

30 August 2018

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Prognostic and clinicopathological significance of glypican-3 overexpression in hepatocellular carcinoma: a meta-analysis

30 August 2018

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30 August 2018

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Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies.

30 August 2018

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30 August 2018

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Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice.

30 August 2018

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An EpCAM/CD3 bispecific antibody efficiently eliminates hepatocellular carcinoma cells with limited galectin-1 expression

30 August 2018

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30 August 2018

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30 August 2018

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T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice.

30 August 2018

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30 August 2018

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30 August 2018

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Circulating stem cell-like epithelial cell adhesion molecule-positive tumor cells indicate poor prognosis of hepatocellular carcinoma after curative resection

30 August 2018

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Discrete nature of EpCAM+ and CD90+ cancer stem cells in human hepatocellular carcinoma

30 August 2018

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CD133(+)EpCAM(+) phenotype possesses more characteristics of tumor initiating cells in hepatocellular carcinoma Huh7 cells

30 August 2018

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What is the potential role of hepatic arterial infusion chemo-therapy in the current armamentorium against colorectal cancer

30 August 2018

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B7-H3 is expressed in human hepatocellular carcinoma and is associated with tumor aggressiveness and postoperative recurrence

30 August 2018

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OV6⁺ tumor-initiating cells contribute to tumor progression and invasion in human hepatocellular carcinoma

30 August 2018

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30 August 2018

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Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma.

30 August 2018

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Expression of IL-15 in NK cells results in rapid enrichment and selective cytotoxicity of gene-modified effectors that carry a tumor-specific antigen receptor

30 August 2018

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DLK1 as a potential target against cancer stem/progenitor cells of hepatocellular carcinoma

30 August 2018

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Inducible apoptosis as a safety switch for adoptive cell therapy

30 August 2018

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Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma

30 August 2018

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Identification of osteopontin as a novel marker for early hepatocellular carcinoma

30 August 2018

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Hepatitis C virus-induced cancer stem cell-like signatures in cell culture and murine tumor xenografts

30 August 2018

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Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia

30 August 2018

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CD24+ Liver Tumor-Initiating Cells Drive Self-Renewal and Tumor Initiation through STAT3-Mediated NANOG Regulation

30 August 2018

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Novel Monoclonal Antibodies for Cancer Treatment: The Trifunctional Antibody Catumaxomab (Removab®)

30 August 2018

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Epithelial cell adhesion molecule expression (CD326) in cancer: A short review

30 August 2018

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Tumor-infiltrating immune cells and prognosis: the potential link between conventional cancer therapy and immunity

30 August 2018

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Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1

30 August 2018

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Overexpression of osteopontin in hepatocellular carcinoma and its relationships with metastasis, invasion of tumor cells

30 August 2018

1 reference

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Glypican-3: A new target for cancer immunotherapy

30 August 2018

1 reference

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Concentrations of EpCAM ectodomain as found in sera of cancer patients do not significantly impact redirected lysis and T-cell activation by EpCAM/CD3-bispecific BiTE antibody MT110.

30 August 2018

1 reference

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A bispecific antibody effectively inhibits tumor growth and metastasis by simultaneous blocking vascular endothelial growth factor A and osteopontin

30 August 2018

1 reference

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CD13 is a therapeutic target in human liver cancer stem cells

30 August 2018

1 reference

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PD-1 and PD-L1 upregulation promotes CD8(+) T-cell apoptosis and postoperative recurrence in hepatocellular carcinoma patients.

30 August 2018

1 reference

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Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2

30 August 2018

1 reference

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Cancer stem/progenitor cells are highly enriched in CD133+CD44+ population in hepatocellular carcinoma

30 August 2018

1 reference

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EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features

30 August 2018

1 reference

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High tumor-infiltrating macrophage density predicts poor prognosis in patients with primary hepatocellular carcinoma after resection.

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5496242

EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma

30 August 2018

1 reference

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Significance of CD90+ cancer stem cells in human liver cancer

30 August 2018

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Liver: An organ with predominant innate immunity

30 August 2018

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T cells redirected against hepatitis B virus surface proteins eliminate infected hepatocytes.

30 August 2018

1 reference

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CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity

30 August 2018

1 reference

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Difference in cytotoxicity against hepatocellular carcinoma between liver and periphery natural killer cells in humans.

30 August 2018

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Vascular endothelial growth factor: basic science and clinical progress

30 August 2018

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Glypican-3, overexpressed specifically in human hepatocellular carcinoma, is a novel tumor marker.

30 August 2018

1 reference

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Overexpression of osteopontin in hepatocellular carcinoma

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5496242

Rac regulates vascular endothelial growth factor stimulated motility

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5496242

Dual mechanism of vascular endothelial growth factor upregulation by hypoxia in human hepatocellular carcinoma

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5496242

Cloning and expression of a developmentally regulated transcript MXR7 in hepatocellular carcinoma: biological significance and temporospatial distribution

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5496242

A new in vitro model of specific targeting therapy of cancer: retargeting of PWM-LAK cells with bispecific antibodies greatly enhances cytotoxicity to hepatocellular carcinoma

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5496242

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5496242

Membrane staining for hepatitis B surface antigen on hepatocytes: a sensitive and specific marker of active viral replication in hepatitis B

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5496242

Targeting of "T" lymphocytes against human hepatoma cells by a bispecific monoclonal antibody: role of different lymphocyte subsets

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5496242

Natural killer cell activity in patients with hepatocellular carcinoma relative to early development and tumor invasion

30 August 2018

1 reference

12 December 2020

Increased expression of vascular endothelial growth factor in human hepatocellular carcinoma

1 reference

12 December 2020

CD44s regulates the TGF-β-mediated mesenchymal phenotype and is associated with poor prognosis in patients with hepatocellular carcinoma

1 reference

12 December 2020

Glypican 3 expression in pediatric malignant solid tumors

1 reference

12 December 2020

Chimeric Antigen Receptor-Modified T Cells in Chronic Lymphoid Leukemia; Chimeric Antigen Receptor-Modified T Cells for Acute Lymphoid Leukemia; Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

1 reference

12 December 2020

EpCAM, a new marker for cancer stem cells in hepatocellular carcinoma

1 reference

12 December 2020

Hepatocellular carcinoma-associated mesenchymal stem cells promote hepatocarcinoma progression: role of the S100A4-miR155-SOCS1-MMP9 axis

1 reference

12 December 2020

Overexpression of osteopontin independently correlates with vascular invasion and poor prognosis in patients with hepatocellular carcinoma

1 reference

12 December 2020

Identification of in vitro HSC fate regulators by differential lipid raft clustering

1 reference

12 December 2020

High expression levels of putative hepatic stem/progenitor cell biomarkers related to tumour angiogenesis and poor prognosis of hepatocellular carcinoma

1 reference

12 December 2020

Preparation and application of anti-HBx/anti-CD3 bispecific monoclonal antibody (BsAb) retargeting effector cells for lysis of human hepatoma xenografts in nude mice

1 reference

12 December 2020

Expression of stemness markers (CD133 and EpCAM) in prognostication of hepatocellular carcinoma

1 reference

12 December 2020

Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2

1 reference

12 December 2020

10.1016/J.CANLET.2017.04.013

Identifiers

DOI

1 reference

10 September 2017

0 references

1 reference