Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. (Q39242962)

10 September 2017

Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. (English)

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10 September 2017

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10 September 2017

Michelle Demory Beckler

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10 September 2017

James N Higginbotham

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10 September 2017

Jeffrey L Franklin

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10 September 2017

Amy-Joan Ham

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10 September 2017

Patrick J Halvey

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10 September 2017

Imade E Imasuen

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10 September 2017

Corbin Whitwell

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10 September 2017

Ming Li

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10 September 2017

Robert J Coffey

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10 September 2017

15 November 2012

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Molecular & Cellular Proteomics

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10 September 2017

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10 September 2017

343-355

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describes a project that uses

10 September 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3567858/fullTextXML

based on heuristic

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Mutant allele-specific imbalance modulates prognostic impact of KRAS mutations in colorectal adenocarcinoma and is associated with worse overall survival

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Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis

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Proteomics analysis of A33 immunoaffinity-purified exosomes released from the human colon tumor cell line LIM1215 reveals a tissue-specific protein signature

10 September 2017

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Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells

10 September 2017

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Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

10 September 2017

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10 September 2017

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Isolation and characterization of exosomes from cell culture supernatants and biological fluids

10 September 2017

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Hyperactive Ras in developmental disorders and cancer

10 September 2017

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Exosomes: a common pathway for a specialized function

10 September 2017

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10 September 2017

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VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

10 September 2017

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10 September 2017

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10 September 2017

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Integrin beta1 is required for the invasive behaviour but not proliferation of squamous cell carcinoma cells in vivo

10 September 2017

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10 September 2017

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A census of human cancer genes

10 September 2017

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Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin

10 September 2017

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10 September 2017

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p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction

10 September 2017

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Role of integrins in cell invasion and migration

10 September 2017

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Exosomes: composition, biogenesis and function

10 September 2017

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Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells

10 September 2017

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The distribution of secondary growths in cancer of the breast. 1889

10 September 2017

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Active Wnt proteins are secreted on exosomes.

10 September 2017

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GeLC-MRM quantitation of mutant KRAS oncoprotein in complex biological samples

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567858

Proteomic consequences of a single gene mutation in a colorectal cancer model

10 September 2017

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Deep proteome and transcriptome mapping of a human cancer cell line

10 September 2017

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Amphiregulin exosomes increase cancer cell invasion.

10 September 2017

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Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.

14 September 2017

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Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins.

14 September 2017

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Difference gel electrophoresis analysis of Ras-transformed fibroblast cell-derived exosomes

14 September 2017

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Differential effects of amphiregulin and TGF-alpha on the morphology of MDCK cells

14 September 2017

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Wildtype Kras2 can inhibit lung carcinogenesis in mice

14 September 2017

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Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles

25 September 2017

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Activated K-ras is involved in regulation of integrin expression in human colon carcinoma cells

25 September 2017

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Oncogenic Ki-ras but not oncogenic Ha-ras blocks integrin beta1-chain maturation in colon epithelial cells

25 September 2017

1 reference

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Auto- and cross-induction within the mammalian epidermal growth factor-related peptide family.

25 September 2017

1 reference

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H-ras resides on clathrin-independent ARF6 vesicles that harbor little RAF-1, but not on clathrin-dependent endosomes.

25 September 2017

1 reference

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Rasosomes spread Ras signals from plasma membrane 'hotspots'.

17 June 2018

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LOH of chromosome 12p correlates with Kras2 mutation in non-small cell lung cancer

17 June 2018

1 reference

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Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression

17 June 2018

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Altered growth of human colon cancer cell lines disrupted at activated Ki-ras

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567858

Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy

17 June 2018

1 reference

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Heat shock protein 70 is secreted from endothelial cells by a non-classical pathway involving exosomes.

21 August 2018

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KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab

21 August 2018

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Ras and its signals diffuse through the cell on randomly moving nanoparticles.

21 August 2018

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Correlation of EPHA2 overexpression with high microvessel count in human primary colorectal cancer

21 August 2018

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NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.

21 August 2018

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Automation of nanoscale microcapillary liquid chromatography-tandem mass spectrometry with a vented column

21 August 2018

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21 August 2018

Identifiers

DOI

10.1074/MCP.M112.022806

1 reference

10 September 2017

1 reference

10 September 2017

PubMed publication ID

23161513

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