Targetting PED/PEA-15 for diabetes treatment. (Q39232367)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28395542%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

title

Targetting PED/PEA-15 for diabetes treatment (English)

1 reference

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17 March 2020

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17 March 2020

Gregoryalexander Raciti

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17 March 2020

Francesca Fiory

1 reference

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17 March 2020

Luca Parrillo

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17 March 2020

Vittoria D'esposito

1 reference

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17 March 2020

Pietro Formisano

1 reference

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17 March 2020

Claudia Miele

1 reference

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17 March 2020

Francesco Beguinot

1 reference

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17 March 2020

language of work or name

English

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publication date

21 April 2017

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Expert Opinion on Therapeutic Targets

17 March 2020

published in

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17 March 2020

volume

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17 March 2020

issue

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17 March 2020

page(s)

571-581

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Phosphoprotein enriched in astrocytes (PEA)-15: a potential therapeutic target in multiple disease states

17 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

The multifunctional protein PEA-15 is involved in the control of apoptosis and cell cycle in astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

On the Quest of Cellular Functions of PEA-15 and the Therapeutic Opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs conserved on their full length in mouse and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Endothelin induces a calcium-dependent phosphorylation of PEA-15 in intact astrocytes: identification of Ser104 and Ser116 phosphorylated, respectively, by protein kinase C and calcium/calmodulin kinase II in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Ferulic acid prevents the cerebral ischemic injury-induced decreases of astrocytic phosphoprotein PEA-15 and its two phosphorylated forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Melatonin attenuates decrease of protein phosphatase 2A subunit B in ischemic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Gingko biloba extract (EGb 761) attenuates ischemic brain injury-induced reduction in Ca(2+) sensor protein hippocalcin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

The expression of PEA-15 (phosphoprotein enriched in astrocytes of 15 kDa) defines subpopulations of astrocytes and neurons throughout the adult mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Human astrocytes are resistant to Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

PEA-15 modulates TNFalpha intracellular signaling in astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

DR5-mediated DISC controls caspase-8 cleavage and initiation of apoptosis in human glioblastomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Inhibition of DNA methylation sensitizes glioblastoma for tumor necrosis factor-related apoptosis-inducing ligand-mediated destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

The PEA-15 protein regulates autophagy via activation of JNK

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

PTEN loss promotes mitochondrially dependent type II Fas-induced apoptosis via PEA-15.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Profound conformational changes of PED/PEA-15 in ERK2 complex revealed by NMR backbone dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

The anti-apoptotic protein PEA-15 is a tight binding inhibitor of ERK1 and ERK2, which blocks docking interactions at the D-recruitment site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

RSK2 activity is regulated by its interaction with PEA-15

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Appropriate therapy for type 2 diabetes mellitus in view of pancreatic β-cell glucose toxicity: "the earlier, the better".

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Recent progress in genetic and epigenetic research on type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Metabolic and genetic characterization of prediabetic states. Sequence of events leading to non-insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Hepatocyte nuclear factor (HNF)-4alpha-driven epigenetic silencing of the human PED gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Protein kinase C (PKC)-alpha activation inhibits PKC-zeta and mediates the action of PED/PEA-15 on glucose transport in the L6 skeletal muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

PED/PEA-15 regulates glucose-induced insulin secretion by restraining potassium channel expression in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

PED/PEA-15 inhibits hydrogen peroxide-induced apoptosis in Ins-1E pancreatic beta-cells via PLD-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Pancreatic α-Cell Dysfunction in Type 2 Diabetes: Old Kids on the Block

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Molecular characterization of the human PEA15 gene on 1q21-q22 and association with type 2 diabetes mellitus in Pima Indians

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Molecular cloning and characterization of the human PED/PEA-15 gene promoter reveal antagonistic regulation by hepatocyte nuclear factor 4alpha and chicken ovalbumin upstream promoter transcription factor II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

miR-212 increases tumor necrosis factor-related apoptosis-inducing ligand sensitivity in non-small cell lung cancer by targeting the antiapoptotic protein PED.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Diabetes and cancer: a consensus report.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Caspase-8 and its inhibitors in RCCs in vivo: the prominent role of ARC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Phosphorylation is the switch that turns PEA-15 from tumor suppressor to tumor promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Bisphosphorylated PEA-15 sensitizes ovarian cancer cells to paclitaxel by impairing the microtubule-destabilizing effect of SCLIP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

The PEA-15/PED protein regulates cellular survival and invasiveness in colorectal carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

PEA-15 induces autophagy in human ovarian cancer cells and is associated with prolonged overall survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

PEA-15 inhibits tumorigenesis in an MDA-MB-468 triple-negative breast cancer xenograft model through increased cytoplasmic localization of activated extracellular signal-regulated kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

PEA-15 facilitates EGFR dephosphorylation via ERK sequestration at increased ER-PM contacts in TNBC cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

PEA-15 inhibits tumor cell invasion by binding to extracellular signal-regulated kinase 1/2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

PEA-15 is inhibited by adenovirus E1A and plays a role in ERK nuclear export and Ras-induced senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Raised expression of the antiapoptotic protein ped/pea-15 increases susceptibility to chemically induced skin tumor development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

High ERK protein expression levels correlate with shorter survival in triple-negative breast cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

PED/PEA-15 interacts with the 67 kD laminin receptor and regulates cell adhesion, migration, proliferation and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

PED interacts with Rac1 and regulates cell migration/invasion processes in human non-small cell lung cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

DNA damage and the balance between survival and death in cancer biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

PED mediates AKT-dependent chemoresistance in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

PED is overexpressed and mediates TRAIL resistance in human non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

The PEA-15/PED protein protects glioblastoma cells from glucose deprivation-induced apoptosis via the ERK/MAP kinase pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Epigalocatechin-3-gallate (EGCG) downregulates PEA15 and thereby augments TRAIL-mediated apoptosis in malignant glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Vitamin D3 signalling in the brain enhances the function of phosphoprotein enriched in astrocytes--15 kD (PEA-15).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Frontiers: PED/PEA-15, a multifunctional protein controlling cell survival and glucose metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Expression and purification of the D4 region of PLD1 and characterization of its interaction with PED-PEA15.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Adenoviral gene transfer of PLD1-D4 enhances insulin sensitivity in mice by disrupting phospholipase D1 interaction with PED/PEA-15.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Residues 762-801 of PLD1 mediate the interaction with PED/PEA15.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Molecular basis of the PED/PEA15 interaction with the C-terminal fragment of phospholipase D1 revealed by NMR spectroscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

The complete primary structure of protein kinase C--the major phorbol ester receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

PKC-alpha regulates cardiac contractility and propensity toward heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Targeting phospholipase D with small-molecule inhibitors as a potential therapeutic approach for cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Binding of small molecules to an adaptive protein-protein interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

Discovery of Small Peptide Antagonists of PED/PEA15–D4α Interaction from Simplified Combinatorial Libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1317749

10.1080/14728222.2017.1317749

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28395542%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28395542%20AND%20SRC:MED&resulttype=core&format=json