Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens. (Q39170177)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23563200%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens (English)

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28 February 2020

main subject

cell line

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Merkel cell carcinoma

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28 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23563200%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Christina Dreher

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28 February 2020

Sabrina Angermeyer

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28 February 2020

Andreas Borst

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28 February 2020

Sebastian Haferkamp

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28 February 2020

Wiebke K Peitsch

1 reference

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28 February 2020

David Schrama

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28 February 2020

Sonja Hesbacher

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28 February 2020

language of work or name

English

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publication date

5 April 2013

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Journal of Investigative Dermatology

28 February 2020

published in

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28 February 2020

volume

133

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28 February 2020

issue

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28 February 2020

page(s)

2453-2460

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describes a project that uses

28 February 2020

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Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53

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Merkel cell carcinoma

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Loss of function and p53 protein stabilization

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Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens

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Clonal integration of a polyomavirus in human Merkel cell carcinoma

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Update on human polyomaviruses and cancer

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pRB-dependent, J domain-independent function of simian virus 40 large T antigen in override of p53 growth suppression

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p53 and metabolism: Inside the TIGAR.

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The p53 pathway: positive and negative feedback loops

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Merkel cell carcinoma: changing incidence trends

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An intact retinoblastoma protein-binding site in Merkel cell polyomavirus large T antigen is required for promoting growth of Merkel cell carcinoma cells

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Merkel cell carcinoma and Merkel cell polyomavirus: evidence for hit-and-run oncogenesis

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High-level expression of wild-type p53 in melanoma cells is frequently associated with inactivity in p53 reporter gene assays

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Activation of the MAP kinase pathway induces apoptosis in the Merkel cell carcinoma cell line UISO.

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Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens

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Regulation of p53 stability by Mdm2

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p14ARF Hypermethylation Is Common but INK4a-ARF Locus or p53 Mutations Are Rare in Merkel Cell Carcinoma

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The complexity of p53 stabilization and activation

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Merkel cell carcinoma: more deaths but still no pathway to blame

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Characterisation of four Merkel cell carcinoma adherent cell lines

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The common mechanisms of transformation by the small DNA tumor viruses: The inactivation of tumor suppressor gene products: p53.

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The ability of large T antigen to complex with p53 is necessary for the increased life span and partial transformation of human cells by simian virus 40.

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The p53-Mdm2 module and the ubiquitin system.

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

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ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis

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Levels of HdmX Expression Dictate the Sensitivity of Normal and Transformed Cells to Nutlin-3

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Cisplatin-based chemotherapy for merkel cell carcinoma of the skin

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Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

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Role of T antigen interactions with p53 in tumorigenesis

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7 January 2021

High-risk Merkel cell carcinoma of the skin treated with synchronous carboplatin/etoposide and radiation: a Trans-Tasman Radiation Oncology Group Study--TROG 96:07.

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Does chemotherapy improve survival in high-risk stage I and II Merkel cell carcinoma of the skin?

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Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus

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Mutant p53: gain-of-function oncoproteins and wild-type p53 inactivators

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Merkel cell carcinoma: in vitro and in vivo characteristics of a new cell line.

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Simian virus 40 T antigen can regulate p53-mediated transcription independent of binding p53.

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Merkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesis

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Recent Advances in the Therapeutic Perspectives of Nutlin-3

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Divorcing ARF and p53: an unsettled case

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T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus

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Merkel cell polyomavirus infection, large T antigen, retinoblastoma protein and outcome in Merkel cell carcinoma

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Gain of function of p53 cancer mutants in disrupting critical DNA damage response pathways

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p53 alterations in human cancer: more questions than answers.

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Chemotherapy in neuroendocrine/Merkel cell carcinoma of the skin: case series and review of 204 cases

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Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

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