Necrosis in DU145 prostate cancer spheroids induces COX-2/mPGES-1-derived PGE2 to promote tumor growth and to inhibit T cell activation (Q39174587)

9 September 2017

title

Necrosis in DU145 prostate cancer spheroids induces COX-2/mPGES-1-derived PGE2 to promote tumor growth and to inhibit T cell activation (English)

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9 September 2017

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Olof Rådmark

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9 September 2017

Bernhard Brüne

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9 September 2017

Weixiao Sha

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9 September 2017

Catherine Olesch

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9 September 2017

Hiromi Hanaka

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9 September 2017

Andreas Weigert

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9 September 2017

language of work or name

English

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publication date

22 April 2013

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International Journal of Cancer

9 September 2017

published in

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9 September 2017

volume

133

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9 September 2017

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9 September 2017

page(s)

1578-1588

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Immune surveillance against a solid tumor fails because of immunological ignorance

9 September 2017

cites work

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Prostaglandins and inflammation

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Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice

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Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells

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Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity

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Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells.

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Dimethylcelecoxib inhibits mPGES-1 promoter activity by influencing EGR1 and NF-κB

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WNT and cyclooxygenase-2 cross-talk accelerates adenoma growth

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Adaptive immunity maintains occult cancer in an equilibrium state

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Prostaglandin E2 inhibits IFN-alpha secretion and Th1 costimulation by human plasmacytoid dendritic cells via E-prostanoid 2 and E-prostanoid 4 receptor engagement

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A fresh look at tumor immunosurveillance and immunotherapy.

21 January 2018

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M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells

21 January 2018

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Signal pathways JNK and NF-kappaB, identified by global gene expression profiling, are involved in regulation of TNFalpha-induced mPGES-1 and COX-2 expression in gingival fibroblasts

21 January 2018

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Transforming growth factor beta regulates cyclooxygenase-2 in glomerular mesangial cells

21 January 2018

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Colon tumour cells increase PGE(2) by regulating COX-2 and 15-PGDH to promote survival during the microenvironmental stress of glucose deprivation

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Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration

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Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy

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Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2.

21 January 2018

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Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system

21 January 2018

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Apoptotic cell-derived sphingosine-1-phosphate promotes HuR-dependent cyclooxygenase-2 mRNA stabilization and protein expression

21 January 2018

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Combinational therapy: new hope for pancreatic cancer?

21 January 2018

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Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors

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Cell death in the neighbourhood: direct microenvironmental effects of apoptosis in normal and neoplastic tissues

21 January 2018

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Killing a cancer: what are the alternatives?

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Regulation of immune responses by prostaglandin E2

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Prostaglandin E2, an immunoactivator.

21 January 2018

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Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion

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21 January 2018

Identifiers

DOI

10.1002/IJC.28181

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9 September 2017

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