RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress. (Q39008812)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24694934%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

title

RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress (English)

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12 March 2020

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Denis Serge François Biard

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12 March 2020

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12 March 2020

Magtouf Gatei

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12 March 2020

Amanda W Kijas

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12 March 2020

Martin F Lavin

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12 March 2020

publication date

2 April 2014

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12 March 2020

published in

Human Molecular Genetics

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12 March 2020

volume

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12 March 2020

issue

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12 March 2020

page(s)

4232-4248

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The DNA Damage Response: Making It Safe to Play with Knives

12 March 2020

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Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination

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The MRX complex stabilizes the replisome independently of the S phase checkpoint during replication stress

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The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair

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Involvement of novel autophosphorylation sites in ATM activation

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Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

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PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin

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ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control

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SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

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The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment.

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Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

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Rapid activation of ATR by ionizing radiation requires ATM and Mre11

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MDC1 collaborates with TopBP1 in DNA replication checkpoint control

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Nbs1 is required for ATR-dependent phosphorylation events

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A role for the MRN complex in ATR activation via TOPBP1 recruitment

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Cohesin association to replication sites depends on rad50 and promotes fork restart

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ATR: an essential regulator of genome integrity

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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

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ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling

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