Extracellular iron diminishes anticancer effects of vitamin C: an in vitro study (Q38968714)

8 September 2017

Extracellular iron diminishes anticancer effects of vitamin C: an in vitro study (English)

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8 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25092529%20AND%20SRC:MED&resulttype=core&format=json

Danijela Maksimović-Ivanić

1 June 2020

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1 June 2020

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1 June 2020

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1 June 2020

author name string

Jelena Bogdanović Pristov

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25092529%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

David R Jones

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1 June 2020

Ivan Spasojević

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1 June 2020

language of work or name

English

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publication date

5 August 2014

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8 September 2017

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1 June 2020

volume

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1 June 2020

page(s)

5955

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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

1 June 2020

start time

5 August 2014

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April 2022 Public Data File from Crossref

copyrighted

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cites work

Review of high-dose intravenous vitamin C as an anticancer agent

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Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

9 September 2017

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The role of iron and reactive oxygen species in cell death

9 September 2017

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The ROS-induced cytotoxicity of ascorbate is attenuated by hypoxia and HIF-1alpha in the NCI60 cancer cell lines.

9 September 2017

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A simple assay for measuring catalase activity: a visual approach

9 September 2017

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Fluctuating vs. continuous exposure to H₂O₂: the effects on mitochondrial membrane potential, intracellular calcium, and NF-κB in astroglia

9 September 2017

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Manganoporphyrins increase ascorbate-induced cytotoxicity by enhancing H2O2 generation

9 September 2017

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Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer

9 September 2017

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High concentrations of L-ascorbic acid specifically inhibit the growth of human leukemic cells via downregulation of HIF-1α transcription.

9 September 2017

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Parenteral ascorbate as a cancer therapeutic: a reassessment based on pharmacokinetics

9 September 2017

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Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial.

9 September 2017

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Ascorbic acid: chemistry, biology and the treatment of cancer.

9 September 2017

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Free radicals and antioxidants at a glance using EPR spectroscopy

9 September 2017

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Comment on "Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer," i.e., all we are saying is, give C a chance

9 September 2017

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Hepcidin and disorders of iron metabolism

9 September 2017

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Interstitial fluid: the overlooked component of the tumor microenvironment?

9 September 2017

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Dietary intake and serum levels of iron in relation to oxidative stress in breast cancer patients

9 September 2017

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Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

9 September 2017

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Phase I clinical trial of i.v. ascorbic acid in advanced malignancy

9 September 2017

1 reference

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Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121606

A pilot clinical study of continuous intravenous ascorbate in terminal cancer patients.

9 September 2017

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Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues

9 September 2017

1 reference

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Sodium ascorbate (vitamin C) induces apoptosis in melanoma cells via the down-regulation of transferrin receptor dependent iron uptake

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121606

9 September 2017

Tissue sulfhydryl groups

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121606

Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121606

Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121606

Human suction blister interstitial fluid prevents metal ion-dependent oxidation of low density lipoprotein by macrophages and in cell-free systems

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121606

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue

9 September 2017

1 reference

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The antioxidants of human extracellular fluids

9 September 2017

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

9 September 2017

1 reference

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Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

9 September 2017

1 reference

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Inhibitors of hydroperoxide metabolism enhance ascorbate-induced cytotoxicity

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121606

Pharmacological concentrations of ascorbate radiosensitize glioblastoma multiforme primary cells by increasing oxidative DNA damage and inhibiting G2/M arrest.

9 September 2017

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H(2)O(2)-mediated cytotoxicity of pharmacologic ascorbate concentrations to neuroblastoma cells: potential role of lactate and ferritin

9 September 2017

1 reference

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Measurement of quantity of iron in magnetically labeled cells: comparison among different UV/VIS spectrometric methods

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121606

Sodium ascorbate induces apoptosis in neuroblastoma cell lines by interfering with iron uptake

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121606

Rapid generation of single-tumor spheroids for high-throughput cell function and toxicity analysis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121606

Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121606

Hydrogen peroxide in adaptation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121606

Reactive oxygen species regulate hypoxia-inducible factor 1alpha differentially in cancer and ischemia

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121606

Colorimetric ferrozine-based assay for the quantitation of iron in cultured cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121606

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121606

Differential oxidative status and immune characterization of the early and advanced stages of human breast cancer.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121606

Metalloporphyrin synergizes with ascorbic acid to inhibit cancer cell growth through fenton chemistry

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121606

Bioavailability and catalytic properties of copper and iron for Fenton chemistry in human cerebrospinal fluid

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121606

Uptake of ferrous iron by cultured rat astrocytes.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121606

Iron accumulation in mammary tumor suggests a tug of war between tumor and host for the microelement.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121606

L-Ascorbic acid induces apoptosis in acute myeloid leukemia cells via hydrogen peroxide-mediated mechanisms

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121606

Non-protein bound iron release during chemotherapy in cancer patients

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121606

Oxidative stress in cell culture: an under-appreciated problem?

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121606

The in vitro cytotoxicity of ascorbate depends on the culture medium used to perform the assay and involves hydrogen peroxide

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121606

Iron Kinetics in the Skin of Patients with Iron Overload

21 August 2018

1 reference

12 December 2020

High Levels of Ferritin and its Iron in Fetal Bovine Serum

1 reference

12 December 2020

Determination of carbonyl content in oxidatively modified proteins

1 reference

12 December 2020

Iron uptake promotes hyperoxic injury to alveolar macrophages

1 reference

12 December 2020

Extracellular iron (II) can protect cells from hydrogen peroxide

1 reference

12 December 2020

Interaction of vitamin C and vitamin E during free radical stress in plasma: an ESR study

1 reference

12 December 2020

Determination of iron with bathophenanthroline without deproteinisation

1 reference

12 December 2020

Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response

2 references

12 December 2020

Crossref

https://api.crossref.org/works/10.1038%2FSREP05955

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/SREP05955

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25092529%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

1 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25092529%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

PubMed publication ID

25092529

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25092529%20AND%20SRC:MED&resulttype=core&format=json